日本の女性研究者

神経科学

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Niikura Takako

 
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NameNiikura Takako
AffiliationSophia University
SectionFaculty of Science and Technology, Department of Information and Communication Sciences
Job titleAssociate Professor

Profile

1989-1991 Researcher Safety Research Institute for Chemical Compounds (Japan)
1991-1992 Research Assistant Tonen K.K. Institute of Basic Science (Japan)
1992-1993 Higher Scientific Officer Institute of Virology and Environmental Microbiology, NERC (UK)
1994-1995 Postdoctoral Fellow Thomas Jefferson University, School of Medicine (USA)
1995-1997 Research Associate Michigan State University, Department of Biochemistry (USA)
1997-2007 Assistant Professor/Instructor KEIO University, School of Medicine (Japan)
2007 - 2009 Research Assistant Professor Georgetown University, Department of Neurology (USA)
2009 - 2012 Assistant Professor Simon Fraser University, Faculty of Health Sciences (Canada)
2012-present Associate Professor Sophia University, Faculty of Science and Technology (Japan)

Research Areas

 
  • Neuroscience / Neurophysiology/General neuroscience / 
  • Neuroscience / Nerve anatomy/Neuropathology / 

Published Papers

 
Alteration of global protein SUMOylation in neurons and astrocytes in response to Alzheimer's disease-associated insults.
Maruyama T, Wada H, Abe Y, Niikura T
Biochemical and Biophysical Research Communications   500(2) 470-475   Jun 2018   [Refereed]
SENP1 and SENP2 regulate SUMOylation of amyloid precursor protein.
Maruyama T, Abe Y, Niikura T.
Heliyon   4(4) e00601   Apr 2018   [Refereed]
Humanin affects object recognition and gliosis in short-term cuprizone-treated mice.
Murakami M, Nagahama M, Abe Y, Niikura T
Neuropeptides   66 90-96   Oct 2017   [Refereed]
Soluble APP functions as a vascular niche signal that controls adult neural stem cell number.
Sato Y, Uchida Y, Hu J, Young-Pearse TL, Niikura T, Mukouyama YS.
Development   144(15) 2730-2736   Aug 2017   [Refereed]
Minetaka Murakami, Masatoshi Nagahama, Takuma Maruyama, Takako Niikura
Neuropeptides   62 65-70   Apr 2017   [Refereed]

Misc

 
Advances in Characterization of Neuroprotective Peptide, Humanin.
Arakawa T, Hirano A, Shiraki K, Niikura T, and Kita Y.
Current Medicinal Chemistry   18(36) 5554-5563   2011
Structure analysis of short peptides by analytical ultracentrifugation: Review.
Arakawa T, Niikura T, Kita Y, and Arisaka F.
Drug Discoveries & Therapeutics   3(5) 208-214   Aug 2009
A rescue factor for Alzheimer’s diseases: Discovery, Activity, Structure, and Mechanism.
Arakawa T, Kita Y, and Niikura T
Current Medicinal Chemistry   15(21) 2086-2098   2008
Neuronal cell death in Alzheimer’s disease and its potential therapy with neuroprotective factors.
Niikura T and Nishimoto I
International Journal of Medical and Biological Frontiers   12(3‐4) 199-240   2007
Humanin, a potential peptide for neuroprotective therapy against Alzheimer’s disease.
Takako Niikura
Expert Opinion on Drug Discovery   2(9) 1273-1282   Aug 2007

Books etc

 
Frontiers in Alzheimer’s Disease Research "Neuronal cell death in Alzheimer’s disease and its potential therapy with neuroprotective factors."
Niikura Takako
Nova Science Publishers   2006   ISBN:159454929X

Conference Activities & Talks

 
Post-translational modification of SOD1 by SUMO and the regulation
H Wada, A Takigawa, T Niikura
2017   
Effects of Humanin on cognitive deficit and neuroinflammation by short-term exposure to cuprizone in mice
M Murakami, Y Abe , T Niikura
Society for Neuroscience 46th Annual Meeting 2017   2017   
SENP1 regulates sumoylation of amyloid precursor protein
T Maruyama, Y Abe , T Niikura
Society for Neuroscience 46th Annual Meeting 2017   2017   
Regulation of tau sumoylation by SUMO ligases and proteases
H Wada, T Niikura
Society for Neuroscience 46th Annual Meeting 2017   2017   
SENP1 promote de-sumoylation of amyloid precursor protein
T Maruyama, Y Abe , T Niikura
2017