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Michiyo Tsuru

 
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NameMichiyo Tsuru
URLhttp://www.med.kurume-u.ac.jp/med/sgc/index.html
AffiliationKurume University
SectionDisease Proteomics Genomics Analysis Center
Job titleLecturer
DegreePh.D.(Life Science Dr), 修士(医科学)(久留米大学), 学士(保健衛生学)(北里大学)
Other Affiliation久留米大学先端癌治療研究センターhttp://www.med.kurume-u.ac.jp/med/sentanca/

Profile

EXPERIENCE<br />
4/2014 - Present Kurume University<br />
Lecturer, Disease Proteomics Genomics Analysis Center<br /><br />
4/2008 - 3/2014 Kurume University School of Medicine<br />
Assistant Professor, Department of Orthopedics<br />
]<br />
12/2003 - 3/2008 Kurume University<br />
Post-Doctoral Fellow, Bio Statistics Center<br /><br />
7/2003 - 11/2003 Kurume University School of Medicine<br />
Assistant (volunteer), Department of Immunology<br /><br />
9/1999 - 6/2003 Kurume University School of Medicine<br />
Research Assistant, Instructor of Department of Immunology<br /><br />
1/1992 - 8/1999 Kurume University School of Medicine<br />
Research Assistant, Department of Anatomy<br /><br />
2/1989 - 12/1991 National Kyushu Cancer Center<br />
Gastrointestinal Medicine Department<br /><br />
4/1987 - 2/1989 South Omuta Hospital<br />
Clinical Laboratory Department<br /><br />
EDUCATION<br />
4/2004 - 3/2006<br /><br />
9/2003<br /><br />
4/1983 - 3/1987<br /><br />
4/1985 - 3/1987<br /><br />
Master of Biostatistics, Kurume University School of Medicine, Japan<br /><br />
Ph.D. in Life Sciences, Kitasato University Kanagawa, Japan<br /><br />
Kitasato University, Kanagawa, Japan<br /><br />
Department of Physiology, Keio University School of Medicine, Tokyo, Japan<br />
CERTIFICATES - Completed the course for practical skill of working environment measurement experts (Kitazato Health Science Center, No.121) 5/1986<br />
- Public Health Laboratory Technologist (No.45632)10/1987<br />
- Health Supervisor (No. 40000200560) 7/1991<br />
- Industrial disposal site technical manager authorized by Minister of Health, Labour and Welfare (No. 8519) 4/1991<br />
- Industrial disposal site technical manager authorized by Japan Environmental Sanitation Center (No. 32304)<br /><br />
MEMBERSHIPS - Member, Japan Clinical Cancer Research Organization (JACCRO).<br />
- Member, The Japanese Orthopedics Association.<br />
- Member, Japanese Cancer Association.<br />
- Member, The Molecular Biology Society of Japan.<br />
- Member, The Japanese Society for Bone and Mineral Research.<br /><br />
AWARDS - Research Award, Second European Conference on Bone Morphogenetic Proteins. Gene Therapy using in vivo Electroporation of Human BMP-2 Gene in Klotho mice. 2002<br />
- Research Award, Lilly Fellowship and Research Grant Program for Bone &amp; Mineral Research. 2005<br />
- Research Award, AstraZeneca Research Grant. 2006<br />
- New preventative strategy for human bone metastases targeting a specific novel protein.<br /><br />
SHORT BIOGRAPHY - Enforced the intractable diseases from proteomics, and performed cancer conquest drug design research and development.

研究キーワード

 
Drug Delivery System, , Drug Delivery System, DDS , 電子顕微鏡 , nonclinical test , Proof of Concept: POC , 浸潤・転移 , Cancer Epithelial-Mesenchymal Transition , Ubiquitin , ligament , Mesenchymal stem cells , ossification of posterior longitudinal ligament , Protein modification , 予防 , 創薬 , タンパク質 , アミノ酸 , 転移 , がん , 立体構造 , 骨転移 , first in human: FIH , NMR解析 , アンタゴニスト , 機能性RNA , miRNA , micro RNA , がん遺伝子 , 質量分析 , 骨・軟部腫瘍学 , がん転移 , 橋渡し研究 , proteomics , バイオマーカー , 椎間板ヘルニア

研究分野

 
  • Informatics / Statistical science / SAS
  • Other / Other / Rare Disease:RD Laboratory medicine
  • Life sciences / Tumor diagnostics and therapeutics / Cancer bone metastasis
  • Life sciences / Biophysics / Proteomics
  • Life sciences / Functional biochemistry / Clarification of intractable disease
  • Life sciences / Sports science / Stem cell-derived ligament reconstruction
  • Life sciences / Tumor biology / Cancer metastasis
  • Life sciences / Healthcare management, medical sociology / Omics
  • Life sciences / Orthopedics / Spinal spinal cord · posterior longitudinal ligament ossification

経歴

 
Apr 2014
 - 
Today
Kurume University
 
2008
 - 
2012
School of Medicine, Kurume University
 
Dec 2003
 - 
Mar 2008
Biostatistics Center, Kurume University
 
Dec 2003
 - 
Mar 2008
Ministry of Education,Culture,Sports,Science and Technology
 
Jul 2003
 - 
Nov 2003
School of Medicine, Kurume University
 

学歴

 
Apr 2004
 - 
Mar 2006
Master of Biostatistics, Kurume University School of Medicine
 
2003
 - 
2003
Kitasato University doctor of life sciences
 
Apr 1983
 - 
Mar 1987
Kitasato University
 

受賞

 
Nov 2018
Clinical study on osteoporosis, Japan Osteoporosis Foundation
 
2006
New preventative strategy for human bone metastases targeting a specific novel protein., Research Award, AstraZeneca Research Grant., Research Award, AstraZeneca Research Grant.
 
2005
Research Award, Lilly Felloeship and Research Grant Program for Bone & Mineral Research., Research Award, Lilly Felloeship and Research Grant Program for Bone & Mineral Research.
 
May 2002
Gene Therapy using in vivo Electroporation of Human BMP-2 Gene in Klotho mice., Research Award, Second European Conference on Bone Morphogenetic Proteins., Research Award, Second European Conference on Bone Morphogenetic Proteins.
 

論文

 
Tsuru M, Ono A, Umeyama H, Takeuchi M, Nagata K
PloS one   13(5) e0196204   2018   [Refereed]
Tsuru M, Sata M, Tanaka M, Umeyama H, Kodera Y, Shiwa M, Aoyagi N, Yasuda K, Matsuoka K, Fukuda T, Yamana H, Nagata K
Translational oncology   10(6) 998-1007   Dec 2017   [Refereed]
津留 美智代, 梅山 秀明, 竹内 正弘, 松本 博行, 永田 見生
日本整形外科学会雑誌   90(8) S1664-S1664   Aug 2016
M Tsuru, N Shiba, K Nagata
The Japanese Orthopaedic Association   87(10) 859-864   Oct 2013   [Refereed]
骨転移に特異的なペプチドを探索するため、肝臓癌骨転移患者47例の保存血清を10年間retrospectiveにプロテオーム解析し、対照群(健常者21例、関節リウマチ患者17例)と比較した。さらに、原発癌または転移治療後の患者13例について8年間のprospectiveな解析を行った。結果、健常者と関節リウマチ患者の血清中には存在せずに癌患者のみ存在する分子量約5000Daの低分子ペプチドを見出した。このペプチド抗体は、骨転移だけでなく他の転移にも有用なことが判明したため&quot;転移ペプ...
Tsuru M, Soejima T, Kimura K, Sato K, Toyama Y, Nagata K
Stem Cells Dev   22(14) 2057-2070   Jul 2013   [Refereed]

MISC

 
津留 美智代
Japan Society of Clinical Proteogenomics (JSCP)   2019(0)    2019
津留 美智代
Japan Society of Clinical Proteogenomics (JSCP)   2019(0)    2019
Michiyo Tsuru
http://www.jsbmr.jp/1st_author/328_mtsuru.html      Sep 2018
津留 美智代, 小野 睦, 内田 研造, 戸山 芳昭, 永田 見生
日本整形外科学会雑誌   89(8) S1530-S1530   Sep 2015
津留 美智代, 志波 直人, 永田 見生
日本整形外科学会雑誌   87(10) 859-864   Oct 2013

書籍等出版物

 
H Outa, S Yamagishi (Part:分担執筆, AGEs and OPLL)
Medical Review   2012   ISBN:9784779210051
津留 美智代
医学書院   2010   
津留 美智代 (Part:分担執筆)
羊土社Bioベンチャー   2004   
Edited by, Kai-Uwe Lewandrowski, K Nagata, M Tsuru (Part:分担執筆, Spontaneous Remission of Intervertebral Disk Herni)
Cambridge Scientific, Inc. c/o M&N Toscano   Oct 2003   ISBN:0824743105
Macrophages Advances in Spinal Fusion reveals a new generation of materials and devices for enhanced operations in spinal fusion. This reference showcases emerging research and technologies in areas such as biodegradable implants, drug delivery, s...

講演・口頭発表等

 
Michiyo Tsuru
The 37th Annual Meeting of the Japanese Society for Bone Metabolism   13 Oct 2019   
Michiyo Tsuru
The 15th Annual Meeting of Japan Society for Clinical Proteogenomics   11 May 2019   
Michiyo Tsuru
Togo - Japan sponsored by the Japan Science and Technology Agency (JST), Ministry of Education, Culture, Sports, Science and Technology and the Ministry of Health, Labor and Welfare Co-organized Research Results Fruitful Report   6 Oct 2016   
津留 美智代, 梅山 秀明, 竹内 正弘, 松本 博行, 永田 見生
日本整形外科学会雑誌   Aug 2016   

所属学協会

 
JACCRO , THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE , JAPANESE SOCIETY OF GASTROENTEROLOGY , THE JAPANESE CANCER ASSOCIATION , JAPANESE SOCIETY FOR BONE AND MINERAL RESEARCH

Works(作品等)

 
Ono Pharmaceutical Co, L   その他   1990 - 1991
Ezaki Glico Co   その他   2002
Nippon Striker Co., Lt   その他   2002
Michiyo Tsuru   その他   
Michiyo Tsuru, JRA   その他   

共同研究・競争的資金等の研究課題

 
Grant-in-Aid for Scientific Research (KAKENHI): Grant-in-Aid for Scientific Research (C)
Project Year: Apr 2012 - Mar 2016
Grant-in-Aid for Scientific Research (KAKENHI): Grant-in-Aid for Scientific Research (C)
Project Year: Apr 2009 - Mar 2014
科研費: 基盤研究(C)
Project Year: Apr 2007 - Mar 2011
Grant-in-Aid for Scientific Research (KAKENHI): Grant-in-Aid for Scientific Research(B)
Project Year: Apr 2004 - Mar 2009
MEXT: Human resorces emerging field resource developments
Project Year: Jun 2003 - Mar 2009

産業財産権

 
Michiyo Tsuru
Spinal ligament ossification model non-human animal, diabetes model non-human animal, spinal ligament ossification model cell, screening method, detection method of spinal ligament ossification disease cell, spinal ligament ossification diagnosis ...
Michiyo Tsuru, Kensei Nagata
Cancer metastasis marker and diagnosis method of cancer metastasis using cancer metastasis's peptids.

社会貢献活動

 
[情報提供]  2002 - 2015
[情報提供]  毎日新聞  毎日新聞  23 Apr 2014

その他

 
Oct 2018   Significance of proteomics of unknown disease
May 2018   Protocol
https://www.protocols.io/researchers/michiyo-tsuru
2018   MGI;http://www.informatics.jax.org/reference/j:262080
MGI;http://www.informatics.jax.org/reference/j:262080