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UNOKI Motoko

 
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NameUNOKI Motoko
URLhttp://hyoka.ofc.kyushu-u.ac.jp/search/details/K003847/english.html
AffiliationKyushu University
SectionMedical Institute of Bioregulation, Department of Molecular Genetics, Division of Epigenomics and Development
Job titleAssistant Professor
DegreePh.D.(The University of Tokyo), DVM(Azabu University)
Research funding number30525374
Google AnalyticsUA-139201616-1
ORCID ID0000-0002-9629-3818

Profile

I'm interested in epigenetic code readers, which read DNA methylation status or histone modifications. I had been studying carcinogenesis for more than 10 years since 1999. Since 2010, I started studying establishment of epigenetic codes during development.

Research Interests

 
non-homologous end joining , HELLS , CDCA7 , DNA repair , ICF syndrome , DNA methylation , Histone modification , UHRF1 , Epigenetics , Carcinogenesis

Research Areas

 
  • Biological Science / Developmental biology / 
  • Basic biology / Genetics/Chromosome dynamics / 
  • Basic medicine / Human genetics / 
  • Oncology / Carcinogenesis / 
  • Genome science / Basic genome science / 
  • Biological science / Molecular biology / 
  • Biological science / Cell biology / 

Academic & Professional Experience

 
Oct 2010
 - 
Today
Assistant Professor, Epigenomics and development, Kyushu University
 
May 2008
 - 
Sep 2010
Postdoctoral fellow, RIKEN
 
May 2004
 - 
Apr 2008
Postdoctoral fellow, National Cancer Institute (NIH)
 
Apr 2003
 - 
Apr 2004
Postdoctoral fellow (JSPS-PD), Institute of Medical Science, The University of Tokyo
 
Apr 2001
 - 
Mar 2003
Predoctoral fellow (JSPS-DC2), Institute of Medical Science, The University of Tokyo
 

Education

 
Apr 1999
 - 
Mar 2003
Medical Sciences, The University of Tokyo
 

Published Papers

 
Unoki M, Funabiki H, Velasco G, Francastel C, Sasaki H
The Journal of clinical investigation   129(1) 78-92   Jan 2019   [Refereed]
Matsuda S, Yasukawa T, Sakaguchi Y, Ichiyanagi K, Unoki M, Gotoh K, Fukuda K, Sasaki H, Suzuki T, Kang D
Scientific reports   8(1) 5801   Apr 2018   [Refereed]
Maenohara S, Unoki M, Toh H, Ohishi H, Sharif J, Koseki H, Sasaki H
PLoS genetics   13(10) e1007042   Oct 2017   [Refereed]
Thijssen PE, Ito Y, Grillo G, Wang J, Velasco G, Nitta H, Unoki M, Yoshihara M, Suyama M, Sun Y, Lemmers RJ, de Greef JC, Gennery A, Picco P, Kloeckener-Gruissem B, Güngör T, Reisli I, Picard C, Kebaili K, Roquelaure B, Iwai T, Kondo I, Kubota T, van Ostaijen-Ten Dam MM, van Tol MJ, Weemaes C, Francastel C, van der Maarel SM, Sasaki H
Nature communications   6 7870   Jul 2015   [Refereed]
Nitta H, Unoki M, Ichiyanagi K, Kosho T, Shigemura T, Takahashi H, Velasco G, Francastel C, Picard C, Kubota T, Sasaki H
Journal of human genetics   58(7) 455-460   Jun 2013   [Refereed]
Unoki M, Masuda A, Dohmae N, Arita K, Yoshimatsu M, Iwai Y, Fukui Y, Ueda K, Hamamoto R, Shirakawa M, Sasaki H, Nakamura Y
The Journal of biological chemistry   288 6053-6062   Mar 2013   [Refereed]
Kofunato Y, Kumamoto K, Saitou K, Hayase S, Okayama H, Miyamoto K, Sato Y, Katakura K, Nakamura I, Ohki S, Koyama Y, Unoki M, Takenoshita S
Oncology reports   28 1997-2002   Dec 2012   [Refereed]
Arita K, Isogai S, Oda T, Unoki M, Sugita K, Sekiyama N, Kuwata K, Hamamoto R, Tochio H, Sato M, Ariyoshi M, Shirakawa M
Proceedings of the National Academy of Sciences of the United States of America   109(32) 12950-12955   Aug 2012   [Refereed]
Mori T, Ikeda DD, Yamaguchi Y, Unoki M, NIRF Project
FEBS letters   586 1570-1583   Jun 2012   [Refereed]
Cho HS, Suzuki T, Dohmae N, Hayami S, Unoki M, Yoshimatsu M, Toyokawa G, Takawa M, Chen T, Kurash JK, Field HI, Ponder BA, Nakamura Y, Hamamoto R
Cancer research   71(3) 655-660   Feb 2011   [Refereed]
Unoki M
Recent Patents on Anti-Cancer Drug Discovery   6(1) 116-130   2011
Cho HS, Suzuki T, Dohmae N, Hayami S, Unoki M, Yoshimatsu M, Toyokawa G, Takawa M, Chen T, Kurash JK, Field H, Ponder BA, Nakamura Y, Hamamoto R
Cancer Res.   in press(3) 655-660   2011
Hayami S, Yoshimatsu M, Veerakumarasivam A, Unoki M, Iwai Y, Tsunoda T, Field HI, Kelly JD, Neal DE, Yamaue H, Ponder BAJ, Nakamura Y, Hamamoto R
Molecular Cancer   9(1) 59   2010
Hayami S, Kelly JD, Cho HS, Yoshimatsu M, Unoki M, Tsunoda T, Field HI, Yamaue H, Ponder BAJ, Nakamura Y, Hamamoto R
Int. J. Can.   128(3) 574-586   2010
Yoshimatsu M, Toyokawa G, Hayami S, Unoki M, Tsunoda T, Field HI, Kelly JD, Neal DE, Maehara Y, Ponder BAJ, Nakamura Y, Hamamoto R
Int. J. Can.   128(3) 562-573   2010
M Unoki, Y Daigo, J Koinuma, E Tsuchiya, R Hamamoto, Y Nakamura
Br. J. Cancer   103(2) 217-222   2010
Kumamoto K, Fujita K, Kurotani R, Saito M, Unoki M, Hagiwara N, Shiga H, Bowman ED, Yanaihara N, Okamura S, Nagashima M, Miyamoto K, Takenoshita S, Yokota J, Harris CC
Int. J. Can.   125(6) 1306-1315   2009
Unoki M, Kumamoto K, Harris CC
Curr. Drug Targets   10(5) 442-454   2009
Unoki M, Kumamoto K, Takenoshita S, and Harris CC
Can. Sci.   100(7) 1173-1179   2009
Unoki M, Kelly JD, Neal DE, BAJ Ponder BAJ, Nakamura Y, Hamamoto R
Br. J. Cancer   101(1) 98-105   2009
Brunet J, Pfaff AW, Abidi A, Unoki M, Nakamura Y, Guinard M, Klein JP, Candolfi E, Mousli M.
Cell Microbiol.   10(4) 908-20   2008
Unoki M, Bronner C, Mousli M.
Radiat Res.   169(2) 240-4   2008
Unoki M, Kumamoto K, Robles AI,Shen JC,Zheng ZM, Harris CC.
FEBS Letters   582(28) 3868-3874   2008
Shen JC, Unoki M, Ythier D, Duperray A, Varticovski L, Kumamoto K, Pedeux R, Harris CC.
Cancer Res.   67(6) 2552-8   2007
Unoki M, Shen JC, Zheng ZM, Harris CC.
J Biol Chem.   281(45) 34677-34686   2006
Unoki M, Nishidate T, Nakamura Y.
Oncogene.   23(46) 7601-10   2004
Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia.
Unoki M, Okutsu J, Nakamura Y.
Int J Oncol.   22(6) 1217-23   2003
Unoki M, Nakamura Y.
FEBS Lett.   554(1/2) 67-72   2003
Yamada R, Tanaka T, Unoki M, Nagai T, Sawada T, Ohnishi Y, Tsunoda T, Yukioka M, Maeda A, Suzuki K, Tateishi H, Ochi T, Nakamura Y, Yamamoto K.
Am J Hum Genet.   68(3) 674-85   2001
Association between a single-nucleotide polymorphism in the promoter of the human interleukin-3 gene and rheumatoid arthritis in Japanese patients, and maximum-likelihood estimation of combinatorial effect that two genetic loci have on susceptibil...
Takeoka S, Unoki M, Onouchi Y, Doi S, Fujiwara H, Miyatake A, Fujita K, Inoue I, Nakamura Y, Tamari M.
J Hum Genet.   46(2) 57-63   2001
Suzuki C, Unoki M, Nakamura Y.
J Hum Genet.   46(3) 155-157   2001
Growth and gene expression profile analyses of endometrial cancer cells expressing exogenous PTEN.
Matsushima-Nishiu M, Unoki M, Ono K, Tsunoda T, Minaguchi T, Kuramoto H, Nishida M, Satoh T, Tanaka T, Nakamura Y.
Cancer Res.   61(9) 3741-9   2001
Unoki M, Furuta S, Onouchi Y, Watanabe O, Doi S, Fujiwara H, Miyatake A, Fujita K, Tamari M, Nakamura Y.
Hum Genet.   106(4) 440-6   2000

Books etc

 
Epigenetics and diseases
UNOKI Motoko (Part:Joint Work)
Sep 2013   ISBN:978-4-944157-55-6
Bladder Cancer
UNOKI Motoko, etc (Part:Joint Work, UHRF1 is a potential molecular marker for diagnosis and prognosis of bladder cancer)
INTECH   Dec 2011   ISBN:978-953-307-610-2
Bio venture 2003 July-August
YODOSHA CO .,LTD.   2003   ISBN:4-89706-152-0
Yusuke Nakamura lab manual for basic genome research
YODOSHA CO .,LTD.   2002   ISBN:9784897062754

Conference Activities & Talks

 
Motoko Unoki, Hironori Funabiki, Hiroyuki Sasaki
28 May 2019   
Motoko Unoki
2nd diversity symposium   18 Mar 2019   Kyushu University
Sharmin Aktar, Motoko Unoki, Hiroyuki Sasaki
The 41st Annual Meeting of the Molecular Biology Society of Japan   Nov 2018   
Motoko Unoki, Hironori Funabiki, Hiroyuki Sasaki,
2018 Hot Spring Harbor symposium   18 Oct 2018   
Motoko Unoki, Hiroyuki Sasaki
2018 Hot Spring Harbor symposium   10 Oct 2018   
Motoko Unoki, Hironori Funabiki, Hiroyuki Sasaki
2018 Cold Spring Harbor meeting: Epigenetics & Chromatin   11 Sep 2018   
Motoko Unoki, Hiroyuki Sasaki
The 2018 Cold Spring Harbor Asia Conference   16 Apr 2018   
Sharmin Aktar, Unoki Motoko, Kyohei Arita, Hiroyuki Sasaki
6 Dec 2017   
Motoko Unoki, Hiroyuki Sasaki
France-Japan Epigenetics Workshop 2017   6 Nov 2017   
Shoji Maenohara, Motoko Unoki, Hidehiro Toh, Hiroaki Ohishi, Jafar Sharif, Haruhiko Koseki, Hiroyuki Sasaki
the 4th Cold Spring Harbor Asia conference on Chromatin, Epigenetics and Transcription   9 May 2016   
Hiroaki Ohishi, Motoko Unoki, Kei Fukuda, Kyouhei Hori, Shoji Maenohara, Hatsune Chiba, Takashi Sado, Hiroyuki Sasaki
15 Sep 2015   
Motoko Unoki, Shoji Maenohara, Atsuo Ogura, Kimiko Inoue, Kazuo Yamagata, Hidehiro Toh, Hiroaki Ohishi, Jafar Sharif, Haruhiko Koseki, Koji Ueda, Hiroyuki Sasaki
Sep 2015   
Motoko Unoki, Yataro Daigo, Jyunichiro Koinuma, Eijyu Tsuchiya, Ryuji Hamamoto, Yusuke Nakamura
69th Annual Meeting of the Japanese Cancer Association   Sep 2010   
JMJDX interacts with DEAH (Asp-Glu-Ala-His) box polypeptide 9 (DHX9)
Motoko Unoki, Yusuke Nakamura, Ryuji Hamamoto
AACR 101st Annual Meeting   Apr 2010   
UHRF1 is a novel molecular marker for diagnosis and the prognosis of bladder cancer
Motoko Unoki, Yusuke Nakamura, Ryuji Hamamoto
8th AACR/JCA Joint International Conference   Feb 2010   
UHRF1 is a Novel Molecular Marker for Diagnosis and the Prognosis of Bladder Cancer
Motoko Unoki, Yusuke Nakamura, Ryuji Hamamoto
68th Annual Meeting of the Japanese Cancer Association   Oct 2009   
A novel demethylase candidate, JMJDX, physically associates with nucleolin
Motoko Unoki, Ryuji Hamamoto, Hidewaki Nakagawa, Yusuke Nakamura
AACR 100th Annual Meeting   Apr 2009   
Motoko Unoki, Kensuke Kumamoto, Curtis C. Harris
67th Annual Meeting of the Japanese Cancer Association   Oct 2008   
Motoko Unoki, Jiang Cheng Shen, Zhi-Ming Zheng, Curtis C. Harris
AACR 99th Annual Meeting   Apr 2008   
Regulation of Cell Growth and Motility by Novel Splice Variants of ING4
Motoko Unoki, Jiang Cheng Shen, Zhi-Ming Zheng, Curtis C. Harris
NIH-JSPS Symposium; Frontiers in 21st Century Biomedical Science: Highlights from Japan and the United States   Nov 2007   
Motoko Unoki, Jiang Cheng Shen, Zhi-Ming Zheng, Curtis C. Harris
AACR 98th Annual Meeting   14 Apr 2007   Los Angeles, California
Motoko Unoki, Jiang Cheng Shen, Zhi-Ming Zheng, Curtis C. Harris
AACR 97th Annual Meeting   Apr 2006   
Motoko Unoki, Yusuke Nakamura
6th AACR/JCA Joint International Conference   25 Jan 2004   
Motoko Unoki, Yusuke Nakamura
62nd Annual Meeting of the Japanese Cancer Association   25 Sep 2003   
Motoko Unoki, Yusuke Nakamura
AACR 94th Annual Meeting   Apr 2003   
Motoko Unoki, Yusuke Nakamura
61st Annual Meeting of the Japanese Cancer Association   1 Oct 2002   
Motoko Unoki, Yusuke Nakamura
AACR 93rd Annual meeting   6 Apr 2002   
Motoko Unoki, Yusuke Nakamura
60th Annual Meeting of the Japanese Cancer Association   26 Sep 2001   
Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway
Motoko Unoki, Yusuke Nakamura
Jul 2001   
Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway
Motoko Unoki, Yusuke Nakamura
IMSUT 28th anniversary of foundation symposium   Jun 2001   
Motoko Unoki, Yusuke Nakamura
5th AACR/JCA Joint International Conference   12 Feb 2001   
Motoko Unoki, Yusuke Nakamura
59th Annual Meeting of the Japanese Cancer Association   4 Oct 2000   

Association Memberships

 
American Association for Cancer Research , Japanese Cancer Association , The Japanese Society for Epigenetics , The Japan Society of Human Genetics , The molecular biology society of Japan

Research Grants & Projects

 
ICF syndrome genes CDCA7 and HELLS are essential for DNA damage repir
Project Year: Apr 2017 - Mar 2018    Investigator(s): UNOKI Motoko
Kyushu University: Interdisciplinary Programs in Education and Projects in Research (P&P)
Project Year: Apr 2012 - Apr 2012    Investigator(s): UNOKI Motoko
Kyushu University: P&P
Project Year: Apr 2010 - Mar 2011    Investigator(s): UNOKI Motoko
Identification of novel methyl-DNA binding proteins
Takeda Science Foundation: 
Project Year: Apr 2011 - Mar 2012    Investigator(s): UNOKI Motoko