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神経科学

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SHOSAKU TAKAKO

 
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NameSHOSAKU TAKAKO
AffiliationKanazawa University
SectionInstitute of Medical,Pharmaceutical and Health Sciences, Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Health Sciences
Job titleProfessor
Research funding number60179025

Research Interests

 
hippocampal neuron , endocannabinoid , Physiology in General Neuro and Musculer Physiology

Research Areas

 
  • Neuroscience / Neurochemistry/Neuropharmacology / 
  • Neuroscience / Neurophysiology/General neuroscience / 
  • Basic medicine / General physiology / 

Academic & Professional Experience

 
Apr 1985
 - 
Jul 1986
Faculty of Medicine, Kyoto University
 
Apr 1987
 - 
Mar 1991
Department of Physiology, Osaka Medical College
 
Apr 1991
 - 
Jun 1994
Faculty of Medicine, Kanazawa University
 
Jul 1994
 - 
Nov 1996
Faculty of Medicine, Kanazawa University
 
Dec 1996
 - 
Mar 2005
Graduate School of Medical Science, Kanazawa University
 
Apr 2005
 - 
Today
Faculty of Health Sciences, Kanazawa University
 

Education

 
Apr 1975
 - 
Mar 1979
Kanazawa University
 
Apr 1979
 - 
Mar 1981
Osaka University
 
Apr 1981
 - 
Mar 1985
Graduate School, Division of Medicine, Kyoto University
 

Committee Memberships

 
2007
   
 
Physiol. Soc. Japan  
 
2007
   
 
-: Physiol. Soc. Japan 
 

Published Papers

 
Yoneda M, Sugimoto N, Katakura M, Matsuzaki K, Tanigami H, Yachie A, Ohno-Shosaku T, Shido O.
J Nutr Biochem.   39 110-116   Jan 2017
Hypoxia-induced inhibition of the endocannabinoid system in glioblastoma cells
Sugimoto N, Ishibashi H, Nakamura H, Yachie A, Ohno-Shosaku T
Oncol Rep   38 3702-3708   2017   [Refereed]
Ota T, Yoneda M, Kikuchi Y, Ohno-Shosaku T
J Wellness Health Care   41 37-48   2017   [Refereed]
Availability of three-lever operant task as mouse model for studying motor sequence and skill learning.
Yoneda M, Tabata Y, Echigo R, Kikuchi Y, Ohno-Shosaku T.
Tsuruma Health Sci Soc Kanazawa Univ   39(2) 113-122   Jan 2016
Soltesz I, Alger BE, Kano M, Lee SH, Lovinger DM, Ohno-Shosaku T, Watanabe M
Nat Rev Neurosci   16(5) 264-277   May 2015
Ohno-Shosaku T, Kano M
Curr Opin Neurobiol   29 1-8   Dec 2014
Impaired anticipatory hand movement during a loading task in patients with schizophrenia
KikuchiY, YonedaM, Ohno-ShosakuT
J Tsuruma Health Sci Soc   38 21-28   2014   [Refereed]
Hashimotodani Y,Ohno-Shosaku T,Tanimura A,Kita Y,Sano Y,Shimizu T,Di Marzo V,Kano M
J Physiol      Oct 2013
Sugawara Y,Echigo R,Kashima K,Minami H,Watanabe M,Nishikawa Y,Muranishi M,Yoneda M,Ohno-Shosaku T
Brain Res   1512 9-21   May 2013
Echigo R,Sugimoto N,Yachie A,Ohno-Shosaku T
Oncol Rep   28(4) 1176-80   Oct 2012
Sugimoto N,Shido O,Matsuzaki K,Ohno-Shosaku T,Hitomi Y,Tanaka M,Sawaki T,Fujita Y,Kawanami T,Masaki Y,Okazaki T,Nakamura H,Koizumi S,Yachie A,Umehara H
Cell Physiol Biochem   30(2) 450-7   Jul 2012
Ohno-Shosaku T,Tanimura A,Hashimotodani Y,Kano M
NEUROSCIENTIST   18(2) 119-132   Apr 2012   [Refereed][Invited]
Ohno-Shosaku T,Sugawara Y,Muranishi C,Nagasawa K,Kubono K,Aoki N,Taguchi M,Echigo R,Sugimoto N,Kikuchi Y,Watanabe R,Yoneda M
Brain Res   1421 66-77   Nov 2011
Hashimotodani Y,Ohno-Shosaku T,Yamazaki M,Sakimura K,Kano M
JOURNAL OF NEUROSCIENCE   31(8) 3104-9   Feb 2011
Sugimoto N,Miwa S,Ohno-Shosaku T,Tsuchiya H,Hitomi Y,Nakamura H,Tomita K,Yachie A,Koizumi S
NEUROSCIENCE LETTERS   497(1) 55-9   Jan 2011
Kano M,Ohno-Shosaku T,Hashimotodani Y,Uchigashima M,Watanabe M
PHYSIOLOGICAL REVIEWS   89(1) 309-80   Jan 2009
Hashimotodani Y, Ohno-Shosaku T, Maejima T, Fukami K,Kano M
NEUROPHARMACOLOGY   54 58-67   Jan 2008
Ohno-Shosaku T, Hashimotodani Y, Ano M, Takeda S, Tsubokawa H, Kano M
JOURNAL OF PHYSIOLOGY-LONDON   584(1) 407-418   Oct 2007   [Refereed]
Hashimotodani Y, Ohno-Shosaku T, Watanabe M, Kano M
JOURNAL OF PHYSIOLOGY-LONDON   584(373-380) 373-380   Oct 2007   [Refereed][Invited]
Hashimotodani Y, Ohno-Shosaku T, Kano M
CURRENT OPINION IN NEUROBIOLOGY   17(360-365) 360-365   Jun 2007   [Refereed][Invited]
Hashimotodani Y, Ohno-Shosaku T, Kano M
NEUROSCIENTIST   13(127-137) 127-137   Apr 2007   [Refereed][Invited]
Hashimotodani Y, Ohno-Shosaku T, Kano M
JOURNAL OF NEUROSCIENCE   27(1211-1219) 1211-1219   Jan 2007   [Refereed]
Kawamura Y, Fukaya M, Maejima T, Yoshida T, Miura E, Watanabe M, Ohno-Shosaku T, Kano M
JOURNAL OF NEUROSCIENCE   26(11) 2991-3001   Mar 2006   [Refereed]
Ohno-Shosaku T, Hashimotodani Y, Maejima T, Kano M
CELL CALCIUM   38(3-4) 369-374   Sep 2005   [Refereed][Invited]
Maejima T, Oka S, Hashimotodani Y, Ohno-Shosaku T, Aiba A, Wu D, Waku K, Sugiura T, Kano M.
JOURNAL OF NEUROSCIENCE   25(29) 6826-6835   Jul 2005   [Refereed]
Hashimotodani Y, Ohno-Shosaku T, Tsubokawa H, Ogata H, Emoto K, Maejima T, Araishi K, Shin HS, Kano M
NEURON   45(2) 257-268   Jan 2005   [Refereed]
Yamazaki M, Ohno-Shosaku T, Fukaya M, Kano M, Watanabe M, Sakimura K
NEUROSCIENCE RESEARCH   50(4) 369-374   Dec 2004   [Refereed]
Fukudome Y, Ohno-Shosaku T, Matsui M, Omori Y, Fukaya M, Tsubokawa H, Taketo MM, Watanabe M, Manabe T, Kano M
EUROPEAN JOURNAL OF NEUROSCIENCE   19(10) 2682-2692   May 2004   [Refereed]
Kano M, Ohno-Shosaku T, Maejima T, Yoshida T, Hashimoto K
Curr Neuropharmacol   2 49-57   2004   [Refereed][Invited]
Ohno-Shosaku T, Matsui M, Fukudome Y, Shosaku J, Tsubokawa H, Taketo MM, Manabe T, Kano M
EUROPEAN JOURNAL OF NEUROSCIENCE   18 109-116   Jul 2003   [Refereed]
Presynaptic cannabinoid sensitivity is a major determinant of depolarization-induced retrograde suppression at hippocampal synapses
Ohno-Shosaku T, Tsubokawa H, Mizushima I, Yoneda N, Zimmer A, Kano M
JOURNAL OF NEUROSCIENCE   22(10) 3864-3872   May 2002   [Refereed]
Ohno-Shosaku T, Shosaku J, Tsubokawa H, Kano M
EUROPEAN JOURNAL OF NEUROSCIENCE   15(6) 953-961   Mar 2002   [Refereed]
Kano M, Ohno-Shosaku T, Maejima T
MOLECULAR PSYCHIATRY   7(3) 234-235   Mar 2002   [Refereed][Invited]
Ohno-Shosaku T, Maejima T, Kano M
NEURON   29(3) 729-738   Mar 2001   [Refereed]
MAEJIMA T, OHNO‐SHOSAKU T, KANO M
NEUROSCIENCE RESEARCH   40(3) 205-210   2001
Ohno-Shosaku T, Sawada S, Kano M
NEUROSCIENCE RESEARCH   36(1) 67-71   Jan 2000   [Refereed]
Ohno-Shosaku T, Sawada S, Yamamoto C
Pfluegers Archiv (Eur. J. Phsiol.)   435(2) 273-279   May 1998   [Refereed]
Yamamoto C, Sawada S, Ohno-Shosaku T
BRAIN RESEARCH   783(2) 227-235   Feb 1998   [Refereed]

Misc

 
Endocannabinoid-mediated retrograde modulation of synaptic transmission
NEUROSCIENCE RESEARCH   Supplement 25 S179   Sep 2001
Types of mGluR involved in depolarization-induced suppression of inhibition (DSI) in rat hippocampal culture
The Japanese Journal of Physiology   50(Supplement) S127   2000
Effects of CaM kinase II inhibitors on DSI in rat hippocampal culture
NEUROSCIENCE RESEARCH   Supplement 23 S85   1999
Possible involvement of retrograde signaling in modulation of inhibitory transmission in cultured rat hippocampal neurons
The Japanese Journal of Physiology   48(Supplement) S20   Mar 1998
Calcium channels involved in depolarization-induced suppression of inhibition in cultured rat hippocampal neurons
NEUROSCIENCE RESEARCH   Supplement 22 S97   Sep 1998
Modulation of inhibitory transmission by retrograde signaling in cultured rat hippocampal neurons
NEUROSCIENCE RESEARCH   Supplement 21 S60   Jul 1997

Conference Activities & Talks

 
The performance of aged mice in 1-lever, 3-lever, and reverse 3-lever operant task
•Nakagawa M, Usuda A, Tanigami H, Yoneda M, Sugimoto N, Ohno-Shosaku T
27 Jul 2018   
The relationship between prediction-based feedforward motor control during loading task and motor learning during lever pressing task
•Ota T, Kikuchi Y, Yoneda M, Koike Y, Ohno-Shosaku T
26 Jul 2018   
Positive effects of theobromine-containing diet on cerebral CREB/BDNF pathways and motor learning in mice
•Tanigami H, Yoneda M, Sugimoto N, Tabata Y, Katakura M, Matsuzaki K, Yachie A, Shido O, Ohno-Shosaku T
22 Jul 2017   
Impaired reinforcement learning and response inhibition in conflict decisions during probabilistic selection task in schizophrenia patients
•Kikuchi Y, Yoneda M, Terashima S, Takabayashi R, Ota T, Ohno-Shosaku T
22 Jul 2017   
Theobromine crosses the blood brain barrier resulting in increased phosphorylation of vasodilator-stimulated phosphoprotein and cAMP-response element-binding protein in the mouse brain
Sugimoto N, Katakura M, Matsuzaki K, Yoneda M, Sumiyoshi E, Ohno-Shosaku T, Yachie A, Shido O.
21st International Conference of FFC   25 Mar 2017   
Theobromine crosses the blood brain barrier in vivo resulting in increased phosphorylation of vasodilatorstimulated phosphoprotein in the mouse brain
Sugimoto N, Katakura M, Matsuzaki K, Ohno-Shosaku T, Yachie A, Shido O.
Physiology 2016   30 Jul 2016   
Theobromine, the primary methylxanthine found in Theobroma cacao, can pass through the blood-brain barrier in mice
Experimental Biology 2016   6 Apr 2016   
Examination of the effects of theobromine feeding on motor learning and adaptive behavior of mice by using three-lever operant task
Tanigami H, Yoneda M, Tabata Y, Sugimoto N, Ohno-Shosaku T
22 Mar 2016   
Impairment of adaptive behavior in CB1-knockout mice during the one-lever, three-lever and reverse three-lever tasks
Yoneda M, Tabata Y, Kikuchi Y, Ohno-Shosaku T
Neuroscience 2015   28 Jul 2015   
A CB1-independent enhancement of spontaneous synaptic activity by endogenously-released 2-arachidonoylglycerol in cultured hippocampal neurons
Ohno-Shosaku T, Kobayashi S, Nakamoto N, Takagi Y, Sugawara Y
Neuroscience 2015   28 Jul 2015   
A study on the role of CB1 receptors in motor learning using the three-lever operant task
Yoneda M, Tabata Y, Takabayashi R, Ohno-Shosaku T
Neuroscience 2014   12 Sep 2014   
Modulation of synaptic transmission by 2-arachidonoylglycerol and its metabolites
Ohno-Shosaku T, Kano M
Neuroscience 2014   12 Sep 2014   
Impairment of feed-forward motor control in patients with schizophrenia
Kikichi Y, Yoneda M, Echigo R, Nakagawa S, Koike Y, Ohno-Shosaku T
Neuroscience 2014   11 Sep 2014   
Differences in the muscarinic effects of the antipsychotic clozapine and its metabolite N-desmethylclozapine between excitatory and inhibitory hippocampal neurons
Sugawara Y, Ota T, Ohno-Shosaku T
Neuroscience 2014   11 Sep 2014   
Individual differences in prediction-based motor control assessed in unloading task by measuring hand movements and electromyogram
Kikuchi, Y, Hama N, Wakabayashi Y, Kumakiri Y, Yoneda M, Koike Y, Ohno-Shosaku T
Neuro2013   2 Jun 2013   
The three-lever operant task as mouse model of motor sequence and skill learning
Yoneda M, Tabata Y, Kikuchi Y, Ohno-Shosaku T
Neuro2013   2 Jun 2013   
The endocannabinoid 2-arachidonoylglycerol increases the frequency of spontaneous synaptic currents in a CB1/CB2-independent manner
Ohno-Shosaku T, Sugawara Y, Kumakiri Y, Wakabayashi Y, Yoneda M
Neuro2013   2 Jun 2013   
Effects of intracellular Ca2+ level on channel modulation induced by activation of muscarinic receptors in rat cultured hippocampal neurons
Ohno-Shosaku T
36th Congress of the International Union of Physiological Sciences   Jul 2009   

Association Memberships

 
THE PHYSIOLOGICAL SOCIETY OF JAPAN , The Japan Neuroscience Society