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TAKASHIMA Yuuki

 
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NameTAKASHIMA Yuuki
AffiliationTokyo University of Pharmacy and Life Science
SectionSchool of Pharmacy
Job titleAssociate Professor
DegreePh.D. (Pharmacy)(Tokyo University of Pharmacy and Life Science)

Research Interests

 
nanoparticles , poorly water soluble drug , siRNA , Pharmaceutics and Drug Delivery , Nucleic acid Delivery

Research Areas

 
  • Pharmacy / Physical pharmacy / 
  • Biomedical engineering / Biomedical engineering/Biomaterial science and engineering / Drug Delivery System

Academic & Professional Experience

 
Oct 2009
 - 
Today
Associate Professor, Pharmaceutical Technology, Tokyo Univ. of Pharmacy and Life Sciences
 
Apr 2006
 - 
Mar 2008
Pharmaceutics and Drug Delivery, Tokyo Univ. of Pharmacy and Life Sciences
 
Apr 2008
 - 
Mar 2009
Visiting Researcher, Centre of Drug Research, University of Helsink
 
1991
   
 
- Tokyo university of Pharmacy & Life Science, Research Associate
 

Published Papers

 
siRNA delivery nanocarriers for non-invasive ophthalmic administration to posterior segment of eyes
TAKASHIMA Yuuki
PHARM TECH JAPAN   34(5)    May 2018
siRNA delivery systems for skin disorders treatment
Yuuki Takashima, Hisako Ibaraki, Takanori Kanazawa
Drug Delivery System   33(4) 285-292   2018   [Refereed]
Takanori Kanazawa, Kuniko Tamano, Kana Sogabe, Takahiro Endo, Hisako Ibaraki, Yuuki Takashima, and Yasuo Seta
Biol. Pharm. Bull.   40 1929-1933   2017   [Refereed]
Takanori Kanazawa, Mami Kaneko, Takaki Niide, Fuminari Akiyama, Shino Kakizaki, Hisako Ibaraki, Shunsuke Shiraishi, Yuuki Takashima, Toyofumi Suzuki, Yasuo Seta
Int. J. Pharm.   530 195-200   2017   [Refereed]
IBARAKI Hisako, KANAZAWA Takanori, TAKASHIMA Yuuki, OKADA Hiroaki, SETA Yasuo
Molecules (Web)   21(10) WEB ONLY   Oct 2016
1. Takanori Kanazawa, Takahiro Endo, Naoki Arima, Hisako Ibaraki, Yuuki Takashima, Yasuo Seta
Int J Pharm   515 315-323   2016   [Refereed]
KANAZAWA Takanori, YAMAZAKI Mamiko, FUKUDA Tsunehiko, TAKASHIMA Yuuki, OKADA Hiroaki
Biol Pharm Bull   38(4) 559-565 (J-STAGE)   2015
Takanori Kanazawa, Yuki Shizawa, Mau Takeuchi, Kuniko Tamano, Hisako Ibaraki, Yasuo Seta, Yuuki Takashima, Hiroaki Okada
Pharmaceutics   7(3) 294-304   2015   [Refereed]
Tatu Lajunen, Koji Hisazumi, Takanori Kanazawa, Hiroaki Okada, Yasuo Seta, Marjo Yliperttul, Arto Urtti, Yuuki Takashima
Eur J Pharm Sci   62 23-32   2014   [Refereed]
4. Takanori Kanazawa, Kazuki Morisaki, Shohei Suzuki, Yuuki Takashima
Mol Pharm   11 1471-1478   2014   [Refereed]

Books etc

 
最新薬剤学 第11版
TAKASHIMA Yuuki (Part:Joint Work, 局方一般試験法中の製剤試験法)
廣川書店   Mar 2018   
ドラッグデリバリーシステムの新展開Ⅱ-核酸医薬・抗体医薬・ワクチン医療を支えるDDS技術-
TAKASHIMA Yuuki (Part:Joint Work, 経眼網膜標的化リポソーム)
シーエムシー出版   Apr 2012   

Conference Activities & Talks

 
Preparation of RPE-targeted nanocomplex for siRNA delivery to posterior segment of the eye
Yuuki Takashima, Keisuke Segami, Yutaka Fujii, Yuta Adachi, Hisako Ibaraki, Takanori Kanazawa, Yasuo Seta
11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology (Granada, Spain)   19 Mar 2018   
Nose-to-brain siRNA delivery combined with cell-penetrating peptide modified polymer micelles
Takanori Kanazawa, Kazuki Morisaki, Shohei Suzuki, Fuminari Akiyama, Shino Kakizaki, Yuuki Takashima, Toyofumi Suzuki, Yasuo Seta
The 13th Annual Meeting of the Oligonucleotide Therapeutics Society (Bordeaux, France)   24 Sep 2017   
蛍光イメージングを用いた核酸医薬DDSのin vivoおよびex vivo動態評価
TAKASHIMA Yuuki
第26回日本バイオイメージング学会学術集会   17 Sep 2017   
細胞間隙開口ペプチドとリポソームの併用塗布によるNF-κB標的siRNAの皮内送達性向上およびアトピー性皮膚炎治療効果
黒澤菜菜美、茨木ひさ子、金沢貴憲、高島由季、瀬田康生
第61回日本薬学会関東支部会(東京)   16 Sep 2017   
異なる表面物性のリポソームによる緑膿菌バイオフィルム滞留性および障害性の評価
TAKASHIMA Yuuki
第61回日本薬学会関東支部会(東京)   16 Sep 2017   
Therapeutic effects on atopic dermatitis and silencing effect of siRelA-encapsulated flexible liposome with AT1002
Hisako Ibaraki, Takanori Kanazawa, Yuuki Takashima, Yasuo Seta
30 Aug 2017   
Enhancement of Nose-to-Brain Delivery of Macromolecules with Stearate- or Polyethylene Glycol-Modified Arginine-Rich Peptide
Takanori Kanazawa, Mami Kaneko, Takaki Niide, Hisako Ibaraki, Yuuki Takashima, Yasuo Seta
44th Annual Meeting and Exposition of the Controlled Release Society (Boston, MA, USA)   16 Jul 2017   
Neovascularization-suppressive effect in rat retina after eye drop of anti VEGF-siRNA loaded liposomes
Yuuki Takashima, Yuta Adachi, Hisako Ibaraki, Takanori Kanazawa, Yasuo Seta
30 Years of Drug Delivery Research (Kuopio, Finland)   12 Jun 2017   
Distribution of model macromolecule drug in whole brain, nasal mucosa, and trigeminal nerve in rats after intranasal administration with basic peptide based nanocarriers
Takanori Kanazawa, Mami Kaneko, Takaki Niide, Hisako Ibaraki, Yuuki Takashima, Yasuo Seta
6th FIP Pharmaceutical Sciences World Congress 2017 (Stockholm, Sweden)   21 May 2017   
Therapeutic effects on atopic dermatitis and transdermal delivery of siRNA with functional peptides
Hisako Ibaraki, Takanori Kanazawa, Yuuki Takashima, Yasuo Seta
6th FIP Pharmaceutical Sciences World Congress 2017 (Stockholm, Sweden)   21 May 2017   

Teaching Experience

 
  • Pharmaceutics (Tokyo university of pharmacy and life sciences)
  • Drug Delivery System (Tokyo university of pharmacy and life sciences)

Association Memberships

 
THE ACADEMY OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY, JAPAN (APSTJ) , Japan Society of Pharmaceutical Machinery and Engineering (JSPME) , Division of Colloid and Surface Chemistry , THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM , THE SOCIETY OF POWDER TECHNOLOGY, JAPAN , American Association of Pharmaceutical Scientists (AAPS) , THE PHARMACEUTICAL SOCIETY OF JAPAN , Controlled Release Society (CRS)

Works

 
Development of non-invasive siRNA-loaded liposomal eyedrop for targeting posterial segment of the eye (retina)
TAKASHIMA Yuuki   The Others   Apr 2010 - Today
siRNA delivery by multifunctional peptide conjugated MPEG-PCL nanomicelles
TAKASHIMA Yuuki   The Others   2011 - Today
Improved intestinal absorption of a poorly water-soluble oral drug by using mannitol microparticles containing a nano-solid drug dispersion
TAKASHIMA Yuuki   The Others   2000 - Today
Optimal formulation design of self-emulsifying drug delivery system (SMEDDS) based on the solubility of poorly soluble drugs
TAKASHIMA Yuuki   The Others   2009 - 2016
Long-lasting siRNA-loaded injectable PLGA microspheres
TAKASHIMA Yuuki   The Others   2000 - 2008
Spray-drying preparation of microparticles containing cationic PLGA nanospheres as gene carriers for avoiding aggregation of nanospheres
TAKASHIMA Yuuki   The Others   2003 - 2007
Preparation of dry powder inhalation by spray drying method
TAKASHIMA Yuuki   Artistic Activity   2000 - 2006
Effect of Physical Properties of Coating Agent on Microcapsule Film Damage during Tableting
1997 - 2001
Effect of physical property of excipients on stress despersion during tablet compression
TAKASHIMA Yuuki   The Others   1995 - 2001
Suppression of Wisker Growth in Tablets
TAKASHIMA Yuuki   The Others   1993 - 2000

Research Grants & Projects

 
Preparation of retina–targeted siRNA delivery system possessing stability in blood
Japan Society for the Promotion of Science (JSPS)): KAKENHI 22500429
Project Year: Apr 2016 - Mar 2019    Investigator(s): Yuuki Takashima
Development of non-invasive retina-targeted siRNA delivery system for overcoming a blood-retina barrier
Japan Society for the Promotion of Science (JSPS)): KAKENHI 16K01397
Project Year: Apr 2010 - Mar 2013    Investigator(s): Yuuki Takashima