日本の女性研究者

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ESUMI Mariko

 
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NameESUMI Mariko
e-mailesumi.marikonihon-u.ac.jp
AffiliationNihon University
SectionSchool of Medicine Department of Medicine
Research funding number30167291

Research Interests

 
Molecular Pathology , Disease Omics , Oncology , Virology , Hepatocellular Carcinoma , Hepatitis C Virus

Research Areas

 
  • Basic medicine / Experimental pathology / 
  • Basic medicine / Pathological medical chemistry / 
  • Basic medicine / Virology / 
  • Oncology / Tumor biology / 
  • Genome science / Medical genome science / 
  • Oncology / Tumor diagnostics / 

Academic & Professional Experience

 
2017
   
 
Visiting Professor, School of Medicine, Nihon University
 
1979
 - 
1980
Postdoctoral fellow of Japan Society for the Promotion of Science, Faculty of Pharmaceutical Sciences, The University of Tokyo
 
1980
 - 
1982
Research Assistant, Faculty of Pharma-Science, Teikyo University
 
1982
 - 
1983
Flexible Researcher of Society for the Promotion of Cancer Research, Division of Biochemistry, National Cancer Center Research Institute
 
1983
 - 
1986
Research Assistant, School of Medicine, Nihon University
 
1986
 - 
1989
Lecturer, School of Medicine, Nihon University
 
1989
 - 
2016
Associate Professor, School of Medicine, Nihon University
 
2016
 - 
2017
Professor (Research Institute), School of Medicine, Nihon University
 

Education

 
 
 - 
1974
Department of Biophysics and Biochemistry, Faculty of Science, The University of Tokyo
 
1974
 - 
1979
Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo
 

Published Papers

 
Contradictory intrahepatic immune responses activated in high-load hepatitis C virus livers compared with low-load livers
Ishibashi M, Yamaguchi H, Hirotani Y, Sakurada A, Endo T, Sugitani M, Takayama T, and Esumi M
Archives of Virology   163(4) 855-865   2018   [Refereed]
Particular gene upregulation and p53 heterogeneous expression in TP53-mutated maxillary carcinoma
Kudo I, Esumi M, Kusumi Y, Furusaka T, and Oshima T
Oncology Letters   14 4633-4640   2017   [Refereed]
Hasegawa H, Kusumi Y, Asakawa T, Maeda M, Oinuma T, Furusaka T, Oshima T, and Esumi M
BMC Cancer   17 381   2017   [Refereed]
Assessment of the quality of DNA from various formalin-fixed paraffin-embedded (FFPE) tissues and the use of this DNA for next-generation sequencing (NGS) with no artifactual mutation
Einaga N, Yoshida A, Noda H, Suemitsu M, Nakayama Y, Sakurada A, Kawaji Y, Yamaguchi H, Sasaki Y, Tokino T, and Esumi M
PLOS ONE   12(5) e0176280   2017   [Refereed]
Transglutaminase 2 is upregulated in primary hepatocellular carcinoma with early recurrence as determined by proteomic profiles
Yamaguchi H, Kuroda K, Sugitani M, Takayama T, Hasegawa K, and Esumi M
International Journal of Oncology   50(5) 1749-1759   2017   [Refereed]
Nakayama Y, Yamaguchi H, Einaga N, Esumi M
PLOS ONE   11(3) e0150528   2016   [Refereed]
Numaguchi S, Esumi M, Sakamoto M, Endo M, Ebihara T, Soma H, Yoshida A, and Tokuhashi Y
Journal of Orthopaedic Research   34(1) 39-47   2016   [Refereed]
Esumi M, Ishibashi M, Yamaguchi H, Nakajima S, Tai Y, Kikuta S, Sugitani M, Takayama T, Tahara M, Takeda M, and Wakita T.
Hepatology   61(2) 437-446   2015   [Refereed]
Ishibashi M, Morita N, Nomura-Kawaguchi C, Shimizu Y, Wakita T, and Esumi M.
Archives of Virology   159(11) 2949-2955   2014   [Refereed]
Yamaguchi H, Matsumoto S, Ishibashi M, Hasegawa K, Sugitani M, Takayama T, and Esumi M.
Experimental and Molecular Pathology   95(2) 131-135   2013   [Refereed]
Abe M, Tahara M, Sakai K, Yamaguchi H, Kanou K, Shirato K, Kawase M, Noda M, Kimura H, Matsuyama S, Fukuhara H, Mizuta K, Maenaka K, Ami Y, Esumi M, Kato A, and Takeda M
Journal of Virology   87(21) 11930-11935   2013   [Refereed]
Yamaguchi H, Hasegawa K, and Esumi M
Experimental and Molecular Pathology   95(1) 46-50   Aug 2013   [Refereed]
Taniguchi S, Ryu J, Seki M, Sumino T, Tokuhashi Y, Esumi M
Journal of Orthopaedic Research   30(5) 673-678   May 2012   [Refereed]
Asakawa T, Esumi M, Endo S, Kida A, and Ikeda M
BMC Medical Genetics1   13 23   Mar 2012   [Refereed]
Takagi K, Takayama T, Nagase H, Moriguchi M, Wang X, Hirayamagi K, Suzuki T, Hasegawa H, Ochiai T, Yamaguchi N, Kochi M, Kimura M, Esumi M
Experimental and Therapeutic Medicine   2(3) 425-431   May 2011   [Refereed]
Shinojima Y, Terui T, Hara H, Kimura MT, Igarashi J, Wang X, Kawashima H, Kobayashi Y, Muroi S, Hayakawa S, Esumi M, Fujiwara K, Ghosh S, Yamamoto T, Held W, and Nagase H
Journal of Dermatological Science   59(2) 98-106   Jul 2010   [Refereed]
Obikane H, Abiko Y, Ueno H, Kusumi Y, Esumi M, and Mitsumata M
Atherosclerosis   212(1) 116-122   Jul 2010   [Refereed]
Sueyoshi S, Mitsumata M, Kusumi Y, Niihashi M, Esumi M, Yamada T, and Sakurai I
Pathology, Research and Practice   206(7) 429-438   Apr 2010   [Refereed]
Ishibashi M, Wakita T, Esumi M
Biochemical and Biophysical Research Communications    392(3) 397-402,   Jan 2010   [Refereed]
Infection Control of Hospital Epidemiology   24(2) 137-139   2003   [Refereed]
Biallelic inactivation of the von Hippel-Lindau tumor suppressor gene in sporadic renal cell carcinoma.
Journal of Urology   167(2 Part 1) 713-717   2002   [Refereed]
Annals of New York Academy of Science   947 429-432   2001   [Refereed]
Distinct relationship between polypoid growth type and sporadic colorectal carcinomas with microsatellite instability.
Hepatogastroenterology   48(39) 706-710   2001   [Refereed]
Journal of Viral Hepatitis   8(2) 151-156   2001   [Refereed]
Expression of muscarinic receptor genes in the human coronary artery.
Angiology   51(4) 295-300   2000   [Refereed]
Two types of sporadic multiple colorectal cancers with and without HNPCC-like genetic instability.
Hepatogastroenterology   46(30) 3115-3120   1999   [Refereed]
Genetic and serological evidence for multiple instances of unrecognized transmission of hepatitis C virus in hemodialysis units.
Journal of Clinical Microbiology   36(10) 2926-2931   1998   [Refereed]
Replication error frequencies in primary hepatocellular carcinoma : A Comparison of Solitary primary versus multiple primary cancers.
Liver   18(4) 272-276   1998   [Refereed]
Antibody responses to the hepatitis C virus E2 protein : relationship to viraemia and prevalence in anti-HCV seronegative subjects.
J. Med Virol.   51(1) 1-5   1997   [Refereed]
Association analysis of CA repeat polymorphism of the endothelial nitric oxide synthase gene with essential hypertension in Japanese.
Clin. Genet.   51(1) 26-30   1997   [Refereed]
Biochem. Biophys. Res. Commun.   226(3) 791-795   1996   [Refereed]
Arch. Virol.   141(5) 951-958   1996   [Refereed]
Murine humoral immune response against recombinant structural proteins of hepatitis C virus distinct from those of patients.
Microbiol. Immunol   40(2) 169-176   1996   [Refereed]
CA repeat polymorphism of the endothelial nitric oxide synthase gene in the Japanese.
Hum. Hered.   45(5) 301-302   1995   [Refereed]
Isolation and sequence polymorphism of a rat retinoblastoma (RB) gene cDNA.
Gene   161(2) 231-235   1995   [Refereed]
Defective copper binding to apoceruloplasmin in a rat model and patients with Wilson's disease.
Liver   15(3) 135-142   1995   [Refereed]
Biological characteristics of neuroblastoma with spontaneous tumor reduction : a case report.
Journal of Pedriatric Surgery   30(5) 722-723   1995   [Refereed]
A silencer element for the lipoprotein lipase gene promoter and cognate double-and single-stranded DNA-binding proteins.
Molecular and Cellular Biology   15(1) 517-523   1995   [Refereed]
Direct PCR of whole blood and hair shafts by microwave treatment
Biotechniques   17(4) 726-728   1994   [Refereed]
Journal of Medical Virology   43(4) 404-411   1994   [Refereed]
Expression of HCV core protein in Escherichia coli and the establishment of ELISA system.
International Hepatology Communications   2 37-42   1994   [Refereed]
Hepatitis C virus and liver diseases.
Pathology International   44(2) 85-95   1994   [Refereed]
Abnormal accumulation of apo-ceruloplasmin in a rat model of Wilson's disease.
International Hepatology Communications   1 228-232   1993   [Refereed]
Detection of antibody against nonstructural (NS) protein 5 region of hepatitis C virus.
International Hepatology Communications   1 121-127   1993   [Refereed]
Correlation of serum antibody titers against hepatitis C virus core protein with clinical features by western blot (immunoblot) analysis using a recombinant vaccinia virus expression system.
Journal of Clinical Microbiology   31 1173-1178   1993   [Refereed]
Expression and epitope analysis of hepatitis C virus NS1.
International Hepatology Communications   1 31-36   1993   [Refereed]
A rapid molecular diagnosis of posttransfusion graft-versus-host disease by polymerase chain reaction.
Transfusion   33(5) 413-417   1993   [Refereed]
Evaluation of three hepatitis C virus-related antibodies C100, KCL-163, JCC.
Dig Dis. Sic.   (3107) 1489-1494   1992   [Refereed]
Non-A, non-B hepatitis-induced gene expression in chimpanzee liver.
Elsevier Science Publishers, Viral Hepatitis C, D and E   149-150   1991
Isolation of a cDNA clone closely associated with post-transfusion non-A, non-B Hepatitis.
Elsevier Science Publishers, Viral Hepatitis C, D and E   61-63   1991
Oncogene expression in the liver tissue of patients with nonneoplastic liver disease.
Cancer   67(10) 2594-2598   1991
Expression of a multidrug-resistance gene in human malignant lymphoma and related disorders.
Leukemia Research   15(12) 1139-1143   1991
Nucleic Acids Research   18(9) 2685-2689   1990
Persistence of hepatitis B virus DNA after immunological clearance of hepatitis B virus.
Liver   10(1) 6-10   1990
Clonal state of human hepatocellular carcinoma and non-tumorous hepatocytes.
Cancer Chemother. Pharmacol.   (23) S1-S3   1989
State of hepatitis B virus DNA in hepatocytes of patients with noncarcinomatous liver disease.
Arch. Pathol. Lab. Med.   (1131) 20-25   1989
Influence of aflatoxin B1 intoxication on duck livers with duck hepatitis B virus infection.
Cancer Res.   48(6) 1559-1565   1988
Occurrence and ultrastructural localization of duck hepatitis B virus in the liver of ducks after experimental infection.
Hepatology   7(1) 29-36   1987
Clonal origin of human hepatoma determined by integration of hepatitis B virus DNA
Cancer Research   46(11) 5767-5771   1986
New biological significance of indole-containing compounds as inhibitors or tumor promoters in chemical carcinogenesis.
Walter de Gruyter & Co., Progress in Tryptophan and Serotonin Research   793-802   1984
Marine animal lectin-dependent tumor recognition by macrophages.
Gann   74(3) 405-411   1983
Inhibition of murine tumor development by the lectin wheat germ agglutinin.
Gann   74(3) 398-404   1983
Anti-tumor activity of macrophage grown in tumorous ascitic fluid.
Gann   74(1) 155-161   1983
Differential effects of glutaraldehyde treatment of target cells on lectin-dependent macrophage-mediated tumor lysis.
Journal of Reticuloendothelial Society   33(3) 239-246   1983
Comparative studies on antibody and lectin-dependent macrophage-mediated tumorlysis.
Journal of Reticuloendothelial Society   33((22)) 83-92   1983
Modulation and induction of mediator-dependent tumor lysis mediated by macrophages.
Self-defense Mechanisms : Role of macrophages, University of Tokyo Press   295-303   1982
Induction of macrophage-mediated tumor lysis by an animal lectin, Sarcophage peregrina agglutinin.
Gann   73(4) 627-632   1982
Enhanced susceptibility of glutaraldehyde-treated tumor cells to antibody-dependent macrophage-mediated cytolysis
Cancer Research   42(8) 3196-3200   1982
Induction of macrophage-mediated tumor lysis by the lectin wheat germ agglutinin
Cancer Research   40(10) 3798-3803   1980
Macrophage-tumor interaction induced by antibody in antibody-dependent macrophage-mediated tumor lysis.
Journal of Reticuloendothelial Society   28(3) 237-248   1980
Antibody-induced antigen redistribution on murine mammary tumor cells.
Gann   71(4) 530-535   1980
Depression of macrophage function by lipoprotein from tumorous ascites
Gann   71(2) 206-212   1980
In vitro induction of antibody-dependent cytotoxic macrophages by the local anesthetic lidocaine.
Microbiol. Immunol.   22(10) 631-637   1978
Blood group activity of Human sucrase from intestinal metaplasia
Jounal of Biological Chemistry   252(10) 3277-3280   1977

Misc

 
Cross-neutralizing analysis of antibodies against hepatitis C virus hypervariable region 1.
Antiviral Therapy   5(Supplement 1) C43   2000
CLONING AND SEQUENCE ANALYSIS OF HUMAN ZINC TRANSPORTER(ZnT-1)cDNA
The FASEB Journal   11(9) A970   1997
TRANSGENIC MICE WITH HEPATITIS C VIRUS cDNA.
The FASEB Journal   11(9) A1292   1997
C型肝炎ウイルスワクチン-開発は可能か-
nano GIGA   3(6) 995-1000   1994
Molecular cloning and heterogeneity of the human hepatitis C virus (HCV) genome.
Journal of Hepatology   17(Supplement) 94-107   1993
Heterogeneidad del virus C de la hepatitis.
Hepatologia Clinica   87-95   1993
The heterogeneity of hepatitis C viral genome and its direct detection using fluorescent DNA sequencing.
Elsevier Science Publishers, Progress in Clinical Biochemistry   1017-1018   1992
「C型肝炎」-ウイルスとその遺伝子
(22) 1-4   1991

Books etc

 
Epidemiology of hepatitis E
Mariko Esumi
Nippon Rinsho   2015   
Progress in Clinical Biochemistry
Murakawa K, EKambara H, Shikata T (Part:Joint Work)
Elsevier Science Publishers   Oct 1992   
Viral Hepatitis C, D and E
Maeno M, Kaminaka K, Sugimoto H, Hayashi N, Abe K, Sekiguchi S, Yano M, Shikata T (Part:Joint Work)
Elsevier Science Publishers   Apr 1991   
Viral Hepatitis C, D and E
Yamashita S, Kato T, Hayashi N, Maeno M, Sugimoto H, Kaminaka K, Abe K, Shikata T (Part:Joint Work)
Elsevier Science Publishers   Apr 1991   
Progress in Tryptophan and Serotonin Research
Fujiki H, Suganuma M, Tahira T, Nagao M, Wakabayashi K, Sugimura T, Takayama S (Part:Joint Work)
Walter de Gruyter & Co.   Oct 1984   
Self-defense Mechanisms: Role of Macrophages
Yamazaki M, Mizuno D (Part:Joint Work)
University of Tokyo Press   Apr 1982   
Pathology of Carcinogenesis in Digestive Organs
Kawachi T, Matsukura N, Sasajima K, Sano T, Sugimura T (Part:Joint Work)
University of Tokyo Press   Apr 1977   

Conference Activities & Talks

 
Intra-hepatic micro-heterogeneity but a single origin of hepatocellular carcinoma in Long Evans Cinnamon (LEC) rat
7 Oct 2016   
Cancer genome evolution in early hepatocellular carcinoma and premalignant lesions
6 Oct 2016   
Role of Golgi Membrane Protein 1 in Hepatitis C Virus Replication
Yamaguchi H, Kuroda K, Wakita T, Esumi M
21th International Symposium in Hepatitis C Virus and Related Viruses   8 Sep 2014   
Liver microenvironment related to hepatitis C virus loads examined by proteomics of laser-microdissected tissue samples
Yamaguchi H, Kuroda K, Obana Y, Sugitani M, Takayama T, Esumi M
20th International Symposium in Hepatitis C Virus and Related Viruses   8 Oct 2013   
Cell surface serine protease is involved in the hepatitis C virus infection
Esumi M, Nakajima S, Yamaguchi H, Tahi Y, Takeda M, Wakita T
19th International Symposium on Hepatitis C Virus and Related Viruses   6 Oct 2012   
Molecular and histological events induced by cigarette smoke and prostaglandin E1 in the lung of young and old rats
19 Sep 2012   
Proteomics of the liver parenchyma and stroma related to the hepatitis C virus loads
19 Sep 2012   
Serum and trypsin inhibitors inhibit the early step of hepatitis C virus infection
Esumi M, Kikuta S, Yamaguchi H, Nakajima S, Ishibashi M, Wakita T
8th International Symposium on Hepatitis C Virus and Related Viruses   9 Sep 2011   
Liver microenvironment containing cytokeratin 19-positive cells associated with the early recurrence of hepatocellular carcinoma
Esumi M, Yamaguchi H, Kuroda K, Munekata Y, Obana Y, Takahashi R, Fuchinoue F, Sugitani M, Nagase H, Takemura T, Minowa T, Hanagata N, Nakayama H, Takayama T
The 3rd JCA-AACR Special Joint Conference – The Latest Advances in Liver Cancer Research: From Basic Science to Therapeutics   2 Mar 2011   
A Role of Non-parechymal Cells Indicated by Recurrence Proteomics of Hepatocellular Carcinoma from Non-tumorous Liver Tissues
Human Proteome World Congress Sydney 2010   21 Sep 2010   Human Proteome Organization
Signatures for the recurrence of hepatocellular carcinoma determined by proteomics of non-tumorous liver tissues
Esumi M, Yamaguchi H, Kuroda K, Munekata Y, Sugitani M, Fuchinoue F, Hasegawa K, Mamiya T, Takayama T, Kokudo N, Nagase H, Mitsumata M
8th AACR/JCA Joint Conference - Cancer Genomics, Epigenomics, and the Development of Novel Therapeutics   Feb 2010   
Characterization of the proteome from laser microdissection samples of formalin-fixed paraffin-embedded tissue (FFPE/LMD) in autopsy case: comparison among autopsy, biopsy and FFPE/LMD of human liver
Takeya C, Yamaguchi H, Munekata Y, Kuroda K, Nagase H, Takayama T, Yamamoto T, Mitsumata M, Esumi M
第32回日本分子生物学会年会.   Dec 2009   
Hepatitis C virus infection in CLEC4M-transgenic mice
Tsuruda K, Ishibashi M, Yamaguchi H, Fujita J, Tanaka T, Shimizu Y, Wakita T, Suzuki M, Esumi M
第32回日本分子生物学会年会   Dec 2009   
Human liver proteomics between early and late recurrence of hepatocellular carcinoma
Esumi M, Yamaguchi H, Kuroda K, Munekata Y, Sugitani M, Hasegawa K, Mamiya T, Takayama T, Mitsumata M
HUPO2009 World Congress   Sep 2009   
In vitro inihibition of hepatitis C virus replication by 2’-5’-oligoadenylate synthetase-like protein highly induced in vivo in human liver infected with high levels of hepatitis C virus
13th International Symposium on Viral Hepatitis and Liver Disease   21 Mar 2009   
Recurrence-related gene expression in non-tumorous liver tissues of patients with hepatitis C virus-positive hepatocellular carcinoma
9th US-Japan Cellular and Gene Therapy Conference: Genomics and Proteomics Technology in Biomarker Discovery   Feb 2006   
Production and characterization of recombinant Fab fragments against HVR1 of HCV
Nov 2001   
Potentially therapeutic Fab molecules to hepatitis C
Oct 2001   
Analysis of cross-neutralizing activity of antibodies against HCV HVR1
Oct 2000   
Transgenic mice with hepatitis C virus cDNA
17th International Congress of Biochemistry and Molecular Biology (Symposium: Molecular Mechanisms Underlying Infectious Disease: Host-Microbial Interactions and Signaling)   Aug 1997   
Cross-reactivity of anti-hypervariable region 1 (HVR1) antibody against hepatitis C virus (HCV)
Oct 1996   
Cloning and sequencing of hepatitis C virus. Workshop on Molecular Biology of Hepatitis C Virus
Workshop on Molecular Biology of Hepatitis C Virus   Mar 1996   
Antibody response against HCV structural proteins in mice
Jul 1994   
Molecular aspects of hepatocarcinogenesis by hepatitis B virus
Nihon University International Symposium on Applied Biological Science: Biological Function and Application   Jul 1990   
Virology and molecular cloning of hepatitis C virus
National Workshop on Viral Hepatitis in Myanmar   Jul 1990   
Clonal state of human hepatocellular carcinoma and non-tumorous hepatocytes
First International Symposium on Treatment of Liver Cancer   Nov 1987