日本の女性研究者

ゲノム科学

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ARAKI Norie

 
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NameARAKI Norie
URLhttp://srv02.medic.kumamoto-u.ac.jp/dept/tumor/index.html
AffiliationKumamoto University
SectionFaculty of Life Sciences, Faculty of Life Sciences(Basic medicine group),Kumamoto University
Job titleAssociate Professor

Research Interests

 
PROTEINCHEMISTRY , BIOCHEMISTRY , Hepatic cancer , Neural tumor , Cancer Stem Cell , Proteomics , Tumor Genetics and BIology

Research Areas

 
  • Genome science / Genome biology / 
  • Oncology / Tumor biology / 
  • Basic medicine / General medical chemistry / 
  • Biological science / Functional biochemistry / 
  • Basic medicine / Pathological medical chemistry / 

Academic & Professional Experience

 
2007
 - 
Today
Associate Professor, Graduate School of Medical Sciences, Kumamoto University
 
2010
   
 
 Associate Professor,Faculty of Life Sciences(Basic medicine group),Kumamoto University
 
2006
 - 
2007
 Associate Professor,
 
2006
 - 
2007
Associate Professor, Graduate School of Medical Sciences, Kumamoto University
 
2003
 - 
2006
 Lecturer,
 
2003
 - 
2006
Associate Professor, School of Medicine, Kumamoto University
 
2002
 - 
2003
 Lecturer,
 
2002
 - 
2003
Associate Professor, Medical Shool, Kumamoto University
 
1992
 - 
2002
Assistant professor, Medical School, Kumamoto University
 
1992
 - 
2002
 Research Associate,
 

Education

 
1982
 - 
1984
Graduate School Kyushu University
 
1978
 - 
1982
Kyushu University
 

Awards & Honors

 
Jul 2017
Application of integrated proteomics for cancer research, Academic Aword, Japan Proteome Organization
 

Published Papers

 
Miyake K, Baba Y, Ishimoto T, Hiyoshi Y, Iwatsuki M, Miyamoto Y, Yoshida N, Watanabe M, Ogata Y, Nagayama M, Silsirivanit A, Kobayashi D, Araki N, Baba H
Medical oncology (Northwood, London, England)   36(1) 11   Nov 2018   [Refereed]
Kobayashi D, Tokuda T, Sato K, Okanishi H, Nagayama M, Hirayama M, Ohtsuki S, Araki N*
Molecular & cellular proteomics : MCP   18(2) 245-262   Oct 2018   [Refereed]
Fukuda M, Yoshizawa T, Karim MF, Sobuz SU, Korogi W, Kobayasi D, Okanishi H, Tasaki M, Ono K, Sawa T, Sato Y, Chirifu M, Masuda T, Nakamura T, Tanoue H, Nakashima K, Kobashigawa Y, Morioka H, Bober E, Ohtsuki S, Yamagata Y, Ando Y, Oike Y, Araki N, Takeda S, Mizuta H, Yamagata K
Nature communications   9(1) 2833   Jul 2018   [Refereed]
Cho Y, Ideue T, Nagayama M, Araki N, Tani T
Genes to cells : devoted to molecular & cellular mechanisms   23(3) 172-184   Mar 2018   [Refereed]
Saentaweesuk W, Silsirivanit A, Vaeteewoottacharn K, Sawanyawisuth K, Pairojkul C, Cha'on U, Indramanee S, Pinlaor S, Boonmars T, Araki N, Wongkham C
Clinica chimica acta; international journal of clinical chemistry   477 66-71   Feb 2018   [Refereed]
Diwakar Guragain, Wunchana Seubwai, Daiki Kobayashi, Atit Silsinivanit, Atit Silsinivanit, Atit Silsinivanit, Kulthida Vaeteewoottacharn, Kulthida Vaeteewoottacharn, Kanlayanee Sawanyawisuth, Kanlayanee Sawanyawisuth, Chaisiri Wongkham, Chaisiri Wongkham, Sopit Wongkham, Sopit Wongkham, Norie Araki*, Ubon Cha`on
Cellular and Molecular Biology   64(10) 113-118   Jul 2018   [Refereed]
© 2018 by the C.M.B. Association. Chemotherapy for cholangiocarcinoma (CCA) is not quite successful. In this study, we revisited the possibility of artesunate (ART) and chloroquine (CQ), the antimalarial drugs, as therapeutic agents against CCA. T...
Ito N, Katoh K, Kushige H, Saito Y, Umemoto T, Matsuzaki Y, Kiyonari H, Kobayashi D, Soga M, Era T, Araki N, Furuta Y, Suda T, Kida Y, Ohta K
Scientific reports   8(1) 1634   Jan 2018   [Refereed]
Yuki Moriya, Shin Kawano, Shujiro Okuda, Yu Watanabe, Masaki Matsumoto, Tomoyo Takami, Daiki Kobayashi, Yoshinori Yamanouchi, Norie Araki, Akiyasu C. Yoshizawa, Tsuyoshi Tabata, Mio Iwasaki, Naoyuki Sugiyama, Satoshi Tanaka, Susumu Goto*, Yasushi Ishihama,
Nucl Acids Res   in press    Oct 2018   [Refereed]
Saentaweesuk W, Araki N*, Vaeteewoottacharn K, Silsirivanit A, Seubwai W, Talabnin C, Muisuk K, Sripa B, Wongkham S, Okada S, Wongkham C
Oncology research      May 2018   [Refereed]
Okuda S, Watanabe Y, Moriya Y, Kawano S, Yamamoto T, Matsumoto M, Takami T, Kobayashi D, Araki N, Yoshizawa AC, Tabata T, Sugiyama N, Goto S, Ishihama Y
Nucleic acids research   45(D1) D1107-D1111   Jan 2017   [Refereed]
Shujiro Okuda,Yu Watanabe,Yuki Moriya,Array,Tadashi Yamamoto,Masaki Matsumoto,Tomoyo Takami,Daiki Kobayashi,Norie Araki,Akiyasu C. Yoshizawa,Tsuyoshi Tabata,Naoyuki Sugiyama,Susumu Goto,Yasushi Ishihama
Nucleic Acids Research   45(Database-Issue) D1107-D1111   2017   [Refereed]
Izumi D, Ishimoto T, Miyake K, Sugihara H, Eto K, Sawayama H, Yasuda T, Kiyozumi Y, Kaida T, Kurashige J, Imamura Y, Hiyoshi Y, Iwatsuki M, Iwagami S, Baba Y, Sakamoto Y, Miyamoto Y, Yoshida N, Watanabe M, Takamori H, Araki N, Tan P, Baba H
International journal of cancer   138(5) 1207-1219   Mar 2016   [Refereed]
Tokuda K, Kuramitsu Y, Byron B, Kitagawa T, Tokuda N, Kobayashi D, Nagayama M, Araki N, Sonoda KH, Nakamura K
Biochemical and biophysical research communications   463(4) 593-599   Aug 2015   [Refereed]
Kobayashi D, Hirayama M, Komohara Y, Mizuguchi S, Wilson Morifuji M, Ihn H, Takeya M, Kuramochi A, Araki N*
The Journal of biological chemistry   289(38) 26314-26326   Sep 2014   [Refereed]
Shin Kawano, Tsutomu Watanabe,Tsutomu Watanabe,Sohei Mizuguchi,Norie Araki,Toshiaki Katayama,Atsuko Yamaguchi
Nucleic Acids Research   42(Webserver-Issue) 442-448   Jul 2014   [Refereed]
TogoTable (http://togotable.dbcls.jp/) is a web tool that adds user-specified annotations to a table that a user uploads. Annotations are drawn from several biological databases that use the Resource Description Framework (RDF) data model. TogoTab...
Novel translational machinery via TCTP-EF1A2 interaction regulating NF1-associated tumor growth by affinity purification and data-independent mass spectrometry acquisition (AP-DIA/SWATH).
Daiki Kobayashi, Takaho Tokuda, Kyosuke Sato, Hiroki Okanishi, Megumi Nagayama, Mio Hirayama-Kurogi, Sumio Ohtsuki, Norie Araki*.
Molecular & Cellular Proteomics   in press    2018   [Refereed]
Yuko Kuwano, Kazunari Yoneda, Yuya Kawaguchi, Norie Araki, Tomohiro Araki*
Bioscience, Biotechnology and Biochemistry   77(11) 2269-2277   Dec 2013
To determine the structure and functional relationships of invertebrate lysozymes, we isolated a new invertebrate (i)-type lysozyme from the common orient clam (Meretrix lusoria) and determined the complete amino acid sequence of two isozymes that...
Atit Silsirivanit, Atit Silsirivanit, Norie Araki, Chaisiri Wongkham, Kulthida Vaeteewoottacharn, Chawalit Pairojkul, Kazuhiko Kuwahara, Yoshiki Narimatsu, Hiromichi Sawaki, Hisashi Narimatsu, Seiji Okada, Nobuo Sakaguchi, Sopit Wongkham
Cancer Science   104(10) 1278-1284   Oct 2013
Early and specific diagnosis is critical for treatment of cholangiocarcinoma (CCA). In this study, a carbohydrate antigen-S27 (CA-S27) monoclonal antibody (mAb) was established using pooled CCA tissue-extract as immunogen. The epitope recognized b...
Akiko Niibori-Nambu, Uichi Midorikawa, Uichi Midorikawa, Souhei Mizuguchi, Takuichiro Hide, Minako Nagai, Yoshihiro Komohara, Megumi Nagayama, Mio Hirayama, Daiki Kobayashi, Nobuyuki Tsubota, Nobuyuki Tsubota, Tatsuya Takezaki, Keishi Makino, Hideo Nakamura, Motohiro Takeya, Junichi Kuratsu, Norie Araki
PLoS ONE   8(5)    May 2013
Glioma initiating cells (GICs) are considered responsible for the therapeutic resistance and recurrence of malignant glioma. To clarify the molecular mechanism of GIC maintenance/differentiation, we established GIC clones having the potential to d...
Mio Hirayama, Daiki Kobayashi, Souhei Mizuguchi, Souhei Mizuguchi, Takashi Morikawa, Takashi Morikawa, Megumi Nagayama, Uichi Midorikawa, Uichi Midorikawa, Masayo M. Wilson, Akiko N. Nambu, Akiyasu C. Yoshizawa, Akiyasu C. Yoshizawa, Shin Kawano, Norie Araki
Molecular and Cellular Proteomics   12(5) 1377-1394   May 2013
Neurofibromatosis type 1 (NF1) tumor suppressor gene product, neurofibromin, functions in part as a Ras-GAP, and though its loss is implicated in the neuronal abnormality of NF1 patients, its precise cellular function remains unclear. To study the...
Hidetoshi Nitta, Hidetoshi Nitta, Yoshihiro Wada, Yoshiaki Kawano, Yoji Murakami, Atsushi Irie, Keisuke Taniguchi, Ken Kikuchi, Gen Yamada, Kentaro Suzuki, Jiro Honda, Masayo Wilson-Morifuji, Norie Araki, Masatoshi Eto, Hideo Baba, Takahisa Imamura
Clinical Cancer Research   19(8) 2004-2013   Apr 2013
Purpose: The anaphylatoxin C5a is a chemoattractant that induces leukocyte migration via C5a receptor (C5aR). There is emerging evidence that C5a is generated in the cancer microenvironment. We therefore sought C5aR expression and a direct influen...
Hiromitsu Shimada, Hiromitsu Shimada, Akiko Nambu-Niibori, Masayo Wilson-Morifuji, Souhei Mizuguchi, Norie Araki, Hideaki Sumiyoshi, Mitsuru Sato, Yoshihiro Mezaki, Haruki Senoo, Kazushi Ishikawa, Yutaka Hatano, Osamu Okamoto, Sakuhei Fujiwara
Journal of Dermatology   40(4) 249-258   Apr 2013
Elimination of epiplakin (EPPK) by gene targeting in mice results in acceleration of keratinocyte migration during wound healing, suggesting that epithelial cellular EPPK may be important for the regulation of cellular motility. To study the funct...
Tadashi Yamamoto, Keiichi Nakayama, Hisashi Hirano, Takeshi Tomonaga, Yasushi Ishihama, Tetsushi Yamada, Tadashi Kondo, Yoshio Kodera, Yuichi Sato, Norie Araki, Hiroshi Mamitsuka, Naoki Goshima
Journal of Proteome Research   12(1) 58-61   Jan 2013
This article introduces how the human chromosome Xcentric proteome project is carried out by the Japan Chromosome X Project Consortium. The inactivation of one of two chromosomes in female mammals and accumulation of genes related to neural/immune...
Atsushi Irie, Kumiko Harada, Norie Araki, Yasuharu Nishimura
PLoS ONE   7    Dec 2012
We previously reported that protein kinase D2 (PKD2) in T cells is promptly activated after T-cell receptor (TCR) stimulation and involved in the activation of interleukin-2 promoter and T cell death, and that one of its candidate substrate is SET...
Prasong Khaenam, Prasong Khaenam, Prasong Khaenam, Akiko Niibori, Seiji Okada, Patcharee Jearanaikoon, Patcharee Jearanaikoon, Norie Araki, Temduang Limpaiboon, Temduang Limpaiboon, Temduang Limpaiboon
Asian Pacific Journal of Cancer Prevention   13(8) 4007-4011   Jan 2012
Purpose: Retinoblastoma-interacting zinc finger gene (RIZ1) is a tumor suppressor gene which is highly inactivated by promoter hypermethylation in patients with liver fluke-related cholangiocarcinoma (CCA). Epigenetic aberration of this gene might...
Kanlayanee Sawanyawisuth, Chaisiri Wongkham, Norie Araki, Qi Zhao, Gregory J. Riggins, Sopit Wongkham
Asian Pacific Journal of Cancer Prevention   13(SUPPL.1) 89-93   Jan 2012
Cholangiocarcinoma (CCA) continues to be a serious health problem and is the most common fatal cancer in northeastern Thailand. Comprehensive gene expression analysis was here used to identify possible therapeutic targets for CCA treatment. We ass...
Kanlayanee Sawanyawisuth, Chaisiri Wongkham, Gregory J. Riggins, Sopit Wongkham, Norie Araki
Asian Pacific Journal of Cancer Prevention   13(SUPPL.1) 137-141   Jan 2012
Methionine aminopeptidase 2 (MetAP2), a proteolytic enzyme that removes the N-terminal methionine from newly synthesized cellular proteins, plays roles in the development of various cancers and has been found to be over-expressed in cholangiocarci...
Atit Silsirivanit, Atit Silsirivanit, Norie Araki, Chaisiri Wongkham, Chaisiri Wongkham, Chawalit Pairojkul, Chawalit Pairojkul, Yoshiki Narimatsu, Kazuhiko Kuwahara, Hisashi Narimatsu, Sopit Wongkham, Sopit Wongkham, Nobuo Sakaguchi
Cancer   117(15) 3393-3403   Aug 2011
BACKGROUND: The incidence of cholangiocarcinoma (CCA) is increasing globally. Currently, there is no powerful marker for the diagnosis of CCA, which has led to late diagnosis and poor patient outcome. This study was designed to establish a new mon...
Kaori Esaki, Yuya Terashima, Yuya Terashima, Etsuko Toda, Sosuke Yoshinaga, Norie Araki, Kouji Matsushima, Hiroaki Terasawa
Protein Expression and Purification   77(1) 86-91   May 2011
Chemokine receptors play pivotal roles for immune cell recruitment to inflammation sites, in response to chemokine gradients (chemotaxis). The mechanisms of chemokine signaling, especially the initiation of the intracellular signaling cascade, are...
Takeru Nambu, Norie Araki, Aiko Nakagawa, Akihiko Kuniyasu, Tatsuya Kawaguchi, Akinobu Hamada, Hideyuki Saito
Cancer Science   101(1) 137-142   Jan 2010
BCR-ABL tyrosine kinase, generated from the reciprocal chromosomal translocation t(9;22), causes chronic myeloid leukemia (CML). BCR-ABL is inhibited by imatinib; however, several mechanisms of imatinib resistance have been proposed that account f...
Daiki Kobayashi, Jiro Kumagai, Takashi Morikawa, Masayo Wilson-Morifuji, Anthony Wilson, Atsushi Irie, Norie Araki
Molecular and Cellular Proteomics   8(10) 2350-2367   Dec 2009
MS-based quantitative proteomics is widely used for large scale identification of proteins. However, an integrated approach that offers comprehensive proteome coverage, a tool for the quick categorization of the identified proteins, and a standard...
Sopit Wongkham, Sopit Wongkham, Mutita Junking, Mutita Junking, Chaisiri Wongkham, Chaisiri Wongkham, Banchob Sripa, Banchob Sripa, Siri Chur-in, Siri Chur-in, Norie Araki
Cancer Science   100(11) 2077-2084   Nov 2009
Cholangiocarcinoma (CCA) is a fatal disease with high resistance to anticancer drugs. This is probably in part due to enhanced resistance to apoptosis. We have previously shown that galectin-3 (Gal-3), a β-galactoside-binding lectin, is highly exp...
Keiichi Motoyama, Kazuhisa Kameyama, Risako Onodera, Norie Araki, Fumitoshi Hirayama, Kaneto Uekama, Hidetoshi Arima
European Journal of Pharmaceutical Sciences   38(3) 249-261   Oct 2009
Cyclodextrins (CyDs), which are widely used to increase the solubility of drug in pharmaceutical fields, are known to induce hemolysis and cytotoxicity at high concentrations. However, it is still not unclear whether cell death induced by CyDs is ...
Toshihiro Ihara, Toshihiro Ihara, Tatsuaki Ishii, Norie Araki, Anthony W. Wilson, Akinori Jyo
Journal of the American Chemical Society   131(11) 3826-3827   Mar 2009
A simple and easy method for stabilizing DNA triplexes using Ag+is reported. A silver ion displaces the N3 proton of cytosine in Hoogsteen base-pairing to form the base triplet CG.CAg+. By the addition of an equimolar amount of Ag+, the third-stra...
D. Zhang, D. Zhang, T. Shimizu, T. Shimizu, N. Araki, T. Hirota, M. Yoshie, K. Ogawa, N. Nakagata, M. Takeya, H. Saya, H. Saya, H. Saya
Oncogene   27(31) 4305-4314   Jul 2008
Aurora A mitotic kinase is frequently overexpressed in various human cancers and is widely considered to be an oncoprotein. However, the cellular contexts in which Aurora A induces malignancy in vivo are still unclear. We previously reported a mou...
Siriporn Patrakitkomjorn, Daiki Kobayashi, Takashi Morikawa, Masayo Morifuji Wilson, Nobuyuki Tsubota, Atsushi Irie, Tatsuya Ozawa, Masashi Aoki, Nariko Arimura, Kozo Kaibuchi, Hideyuki Saya, Norie Araki, Norie Araki
Journal of Biological Chemistry   283(14) 9399-9413   Apr 2008
Neurofibromatosis type 1 (NF1) tumor suppressor gene product, neurofibromin, functions in part as a Ras-GAP, a negative regulator of Ras. Neurofibromin is implicated in the neuronal abnormality of NF1 patients; however, the precise cellular functi...
Tatsuhiko Sakamoto, Tatsuhiko Sakamoto, Akiyoshi Uezu, Shinya Kawauchi, Takuya Kuramoto, Koji Makino, Kazuaki Umeda, Norie Araki, Hideo Baba, Hiroyuki Nakanishi
Genes to Cells   13(4) 295-312   Apr 2008
Microtubules (MTs) play crucial roles in a variety of cell functions, such as mitosis, vesicle transport and cell motility. MTs also compose specialized structures, such as centrosomes, spindles and cilia. However, molecular mechanisms of these MT...
Mutita Junking, Mutita Junking, Chaisiri Wongkham, Chaisiri Wongkham, Banchob Sripa, Banchob Sripa, Kanlayanee Sawanyawisuth, Kanlayanee Sawanyawisuth, Norie Araki, Sopit Wongkham, Sopit Wongkham
European Journal of Cancer   44(4) 619-626   Mar 2008
Galectin-3, a β-galactoside-binding lectin, is a multifunctional protein implicated in a variety of biological functions, including tumour cell adhesion, proliferation, differentiation, cancer progression and metastasis. The present study was perf...
Yoshiko Tokutomi, Norie Araki, Keiichiro Kataoka, Eiichiro Yamamoto, Shokei Kim-Mitsuyama
Biochemical and Biophysical Research Communications   364 822-830   Dec 2007
To study early changes in angiotensin II (Ang II)-induced signaling with post-translational modifications, we analyzed proteins from cultured human coronary smooth muscle cells stimulated with Ang II, using two-dimensional difference gel electroph...
Akiyoshi Uezu, Ayaka Horiuchi, Kousuke Kanda, Naoya Kikuchi, Kazuaki Umeda, Kazuya Tsujita, Kazuya Tsujita, Shiro Suetsugu, Shiro Suetsugu, Norie Araki, Hideyuki Yamamoto, Hideyuki Yamamoto, Tadaomi Takenawa, Tadaomi Takenawa, Hiroyuki Nakanishi
Journal of Biological Chemistry   282(36) 26481-26489   Sep 2007
SGIP1 has been shown to be an endophilin-interacting protein that regulates energy balance, but its function is not fully understood. Here, we identified its splicing variant of SGIP1 and named it SGIP1α. SGIP1α bound to phosphatidylserine and pho...
Kanlayanee Sawanyawisuth, Kanlayanee Sawanyawisuth, Kanlayanee Sawanyawisuth, Chaisiri Wongkham, Chaisiri Wongkham, Chawalit Pairojkul, Chawalit Pairojkul, O. Tur Saeseow, O. Tur Saeseow, Gregory J. Riggins, Norie Araki, Sopit Wongkham, Sopit Wongkham
Acta Oncologica   46(3) 378-385   Apr 2007
Methionine aminopeptidases (MetAP) are proteases which remove the N-terminal methionine from newly synthesized proteins. Associations of MetAP2 with tumor progression of different cancers have been repeatedly reported. We aim to determine if MetAP...
Atsushi Irie, Kumiko Harada, Hirotake Tsukamoto, Jeong Ran Kim, Norie Araki, Yasuharu Nishimura
International Immunology   18 1737-1747   Dec 2006
Members of protein kinase D (PKD) family serine/threonine kinases (PKD1, PKD2 and PKD3) are expressed in wide range of cells and regulate various cellular responses including immune responses. We have previously shown that PKD is involved in the s...
Masahiko Hirota, Yoshinori Fujimura, Atsushi Ichihara, Norie Araki, Hideo Baba
Japanese Journal of Gastroenterology   103 918-923   Dec 2006
Yoshihiro Komohara, Junko Hirahara, Tomohiro Horikawa, Kyoko Kawamura, Emi Kiyota, Naomi Sakashita, Norie Araki, Motohiro Takeya, Motohiro Takeya
Journal of Histochemistry and Cytochemistry   54 763-771   Jul 2006
CD163 is a member of the scavenger receptor cysteine-rich superfamily restricted to the monocyte/macrophage lineage and is thought to be a useful marker for anti-inflammatory or alternatively activated macrophages. In this study we used mass spect...
Tatsuya Ozawa, Tatsuya Ozawa, Norie Araki, Shunji Yunoue, Hiroshi Tokuo, Liping Feng, Siriporn Patrakitkomjorn, Toshihiro Hara, Yasuko Ichikawa, Kunio Matsumoto, Kiyotaka Fuji, Hideyuki Saya, Hideyuki Saya
Journal of Biological Chemistry   280 39524-39533   Nov 2005
Neurofibromin is a neurofibromatosis type 1 (NF1) tumor suppressor gene product with a domain that acts as a GTPase-activating protein and functions, in part, as a negative regulator of Ras. Loss of neurofibromin expression in NF1 patients is asso...
Noriyoshi Kurihara, Sakamuri V. Reddy, Norie Araki, Seiichi Ishizuka, Keiichi Ozono, Jillian Cornish, Tim Cundy, Frederick R. Singer, G. David Roodman, G. David Roodman, G. David Roodman
Journal of Bone and Mineral Research   19 1154-1164   Jul 2004
In contrast to normal OCL precursors, pagetic OCL precursors express MVNP and form OCL at physiologic concentrations of 1,25(OH)2D3, as do normal OCL precursors transfected with the MVNP gene. Using a GST-VDR chimeric protein, we identified TAFII-...
Liping Feng, Shunji Yunoue, Hiroshi Tokuo, Tatsuya Ozawa, Dongwei Zhang, Siriporn Patrakitkomjorn, Toru Ichimura, Hideyuki Saya, Norie Araki
FEBS Letters   557(1/3) 275-282   Jan 2004
Neurofibromin, a neurofibromatosis type I (NF1) tumor suppressor gene product, has a domain acting as a GTPase activating protein and functions in part as a negative regulator of Ras. Loss of neurofibromin expression in NF1 patients is associated ...
Norie Araki
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme   49 1495-1505   Jan 2004
Shunji Yunoue, Shunji Yunoue, Hiroshi Tokuo, Kohji Fukunaga, Liping Feng, Tatsuya Ozawa, Toru Nishi, Toru Nishi, Akira Kikuchi, Seisuke Hattori, Junichi Kuratsu, Hideyuki Saya, Norie Araki
Journal of Biological Chemistry   278(29) 26958-26969   Jul 2003
Neurofibromin, the neurofibromatosis type 1 (NF1) gene product, contains a central domain homologous to a family of proteins known as Ras-GTPase-activating proteins (Ras-GAPs), which function as negative regulators of Ras. The loss of neurofibromi...
Kazuhiko Watabe, Tsuyoshi Sakamoto, Yoko Kawazoe, Makoto Michikawa, Katsuichi Miyamoto, Takashi Yamamura, Hideyuki Saya, Norie Araki
Neuropathology   23(1) 68-78   Mar 2003
Previously, the authors have established spontaneously immortalized cell lines from long-term cultures of normal adult mouse Schwann cells. Establishment of such Schwann cell lines derived from murine disease models may greatly facilitate studies ...
Tomohiro Araki, Yuki Chijiiwa, Ryoji Nagai, Norie Araki, Seikoh Horiuchi
International Congress Series   1245 391-393   Nov 2002
Recent studies demonstrated N-(carboxymethyl) lysine (CML) and N-(carboxyethyl) lysine (CEL) in several tissues. To elucidate the mechanism of the formation of advanced glycation end product (AGE) structure during incubation of protein with glucos...
Tetsuro Morisaki, Tetsuro Morisaki, Toru Hirota, Shin ichi Iida, Shin ichi Iida, Tomotoshi Marumoto, Toshihiro Hara, Yasuyuki Nishiyama, Yasuyuki Nishiyama, Michio Kawasuzi, Takehisa Hiraoka, Tatsuyuki Mimori, Norie Araki, Ichiro Izawa, Masaki Inagaki, Hideyuki Saya
FEBS Letters   529(2/3) 319-324   Oct 2002
Identification of physiological substrates for Cdc2/cyclin B is crucial for understanding the functional link between mitotic events and Cdc2/cyclin B activation. A human homologue of the Drosophila warts tumor suppressor, termed WARTS, is a serin...
Hirofumi Ochi, Izumi Horiuchi, Norie Araki, Tosifusa Toda, Tomohiro Araki, Kaori Sato, Hiroyuki Murai, Manabu Osoegawa, Takeshi Yamada, Ken Okamura, Tomoaki Ogino, Kiyohisa Mizumoto, Hirohumi Yamashita, Hideyuki Saya, Jun ichi Kira
FEBS Letters   528(1/3) 197-202   Sep 2002
Hashimoto's encephalopathy (HE) is a rare autoimmune disease associated with Hashimoto's thyroiditis (HT). To identify the HE-related autoantigens, we developed a human brain proteome map using two-dimensional electrophoresis and applied it to the...
Norie Araki, Rie Shibayama, Yumiko Ejima, Ryoji Nagai, Tomohiro Araki, Hideyuki Saya, Seikoh Horiuchi
International Congress Series   1223 49-58   Dec 2001
Long-term incubation of proteins with reducing sugar proceeds to advanced glycation end products (AGEs). We previously demonstrated the presence of AGE structures in human and animal tissues, and suggested the implication of AGEs in aging and diab...
Tomohiro Araki, Ryoji Nagai, Norie Araki, Seikoh Horiuchi
International Congress Series   1223 59-64   Dec 2001
To elucidate on the mechanism of the formation of advanced glycation end product (AGE) structure during the incubation of protein with glucose, we analyzed N⋅-(carboxymethyl)lysine (CML) in AGE structure using the immunochemical procedure and amin...
Isamu Okamoto, Isamu Okamoto, Yoshiaki Kawano, Daizo Murakami, Takashi Sasayama, Norie Araki, Toru Miki, Albert J. Wong, Hideyuki Saya, Hideyuki Saya
Journal of Cell Biology   155(5) 755-762   Nov 2001
CD44 is a widely distributed cell surface adhesion molecule and is implicated in diverse biological processes. However, the nature of intracellular signaling triggered by CD44 remains to be elucidated. Here, we show that CD44 undergoes sequential ...
Hiroshi Tokuo, Hiroshi Tokuo, Shunji Yunoue, Liping Feng, Masumi Kimoto, Hideaki Tsuji, Tomomichi Ono, Hideyuki Saya, Norie Araki
FEBS Letters   494(1/2) 48-53   Apr 2001
The neurofibromatosis type 1 (NF1) tumor suppressor (neurofibromin) is thought to play crucial roles in cellular Ras- and cAMP-dependent kinase (PKA)-associated signals. In this study, we identified a cellular neurofibromin-associating protein, NG...
Norie Araki, Hideyuki Saya
Seikagaku   71 128-134   Dec 1999
Hisashi Koga, Hideo Takeshima, Norie Araki, Hideyuki Saya
Gann Monographs on Cancer Research   46 153-163   Jun 1999
Neurofibromatosis 2 (NF2) is an inherited disorder characterized by a predisposition to multiple intracranial tumors. The protein encoded by the NF2 gene has striking similarities to ezrin, radixin and, moesin (ERM) proteins which link membrane pr...
N. Araki, H. Takeshima, H. Saya
Japanese Journal of Cancer and Chemotherapy   24 1427-1431   Nov 1997
Neurofibromatosis type 2 (NF2) is an autosomal dominantly inherited disorder, strongly associated with development of benign intracranial tumors, including bilateral vestibular schwannomas and meningiomas. The NF2 gene located on the human chromos...
Yoji Hamada, Norie Araki, Seikoh Horiuchi, Nigishi Hotta
Nephrology Dialysis Transplantation   11 95-98   Dec 1996
In order to confirm the link between nonenzymatic glycation and the polyol pathway, we observed the effect of treatment with epalrestat (Ep), an aldose reductase inhibitor, on the concentration of advanced glycation end-products (AGEs) in erythroc...
Seikoh Horiuchi, Seikoh Horiuchi, Takayuki Higashi, Kazuyoshi Ikeda, Tetsushi Saishoji, Yoshiteru Jinnouchi, Hiroyuki Sano, Rie Shibayama, Tamami Sakamoto, Norie Araki
Diabetes   45    Dec 1996
Modification of proteins by long-term incubation with glucose leads to the formation of advanced glycation end products (AGEs). AGE proteins are taken up by macrophages via the AGE receptor, which is similar to the macrophage scavenger receptor (M...
Hirofumi Makino, Kenichi Shikata, Masahiko Kushiro, Kazue Hironaka, Yasushi Yamasaki, Hikaru Sugimoto, Zensuke Ota, Norie Araki, Seikoh Horiuchi
Nephrology Dialysis Transplantation   11 76-80   Dec 1996
Available data indicate that the development of diabetic nephropathy is linked to hyperglycaemia. Glucose reacts nonenzymatically with proteins to form Schiff base and Amadori products. Further incubation of these early products leads to the forma...
Jing Meng, Noriyuki Sakata, Shigeo Takebayashi, Shigeo Takebayashi, Takashi Asano, Tetsuhiro Futata, Norie Araki, Seikoh Horiuchi
Diabetes   45 1037-1043   Jan 1996
Recent immunohistological studies using antibodies against advanced glycation end products (AGEs) have demonstrated the presence of AGEs in several tissues. By an enzyme-linked immunosorbent assay using the monoclonal anti-AGE antibody, the presen...
Takemi Kimura, Junichi Takamatsu, Norie Araki, Masamichi Goto, Akira Kondo, Taihei Miyakawa, Seikoh Horiuchi
NeuroReport   6(6) 866-868   Jan 1995
Recent studies have suggested that advanced glycation end-products (AGE) of the Maillard reaction are associated with amyloidosis in Alzheimer’s disease. To evaluate this possibility, the present immunohistochemical study was undertaken to locate ...
M. Nakayama, M. Wada, N. Araki, Y. Ginoza, T. Terahara, K. Harada, A. Sugii, S. Tomiguchi, A. Kojima, M. Hara, M. Takahashi
Nuclear Medicine and Biology   22 795-802   Jan 1995
An insoluble macromolecular Sn(II)(R-Sn) complex which strongly binds Sn(II) by chelation was applied to the direct99mTc labeling of human immunoglobulin(IgG) to minimize the influence of Sn(II).99mTc labeling was achieved at greater than 90% yiel...
Kenichi Shikata, Hirofumi Makino, Hikaru Sugimoto, Masahiko Kushiro, Kosuke Ota, Kenji Akiyama, Norie Araki, Seikoh Horiuchi, Zensuke Ota
Journal of Diabetes and Its Complications   9 269-271   Jan 1995
Advanced glycation endproducts (AGE) have been proposed as a major mediator in the development of various diabetic complications. In order to evaluate the involvement of AGE in the development of diabetic nephropathy, we examined the localization ...
Daisuke SUZUKI, Daisuke SUZUKI, Mitsunori YAGAME, Mitsunori YAGAME, Raita NAKA, Raita NAKA, Kiichiro JINDE, Kiichiro JINDE, Masayuki ENDOH, Masayuki ENDOH, Yasuo NOMOTO, Yasuo NOMOTO, Hideto SAKAI, Hideto SAKAI, Norie ARAKI, Norie ARAKI, Seikoh HORIUCHI, Seikoh HORIUCHI
Nephrology   1 199-205   Jan 1995
Summary: Immunohistochemical staining of glomeruli in patients with diabetic nephropathy (DN) in non‐insulin dependent diabetes mellitus (NIDDM) using the monoclonal anti‐advanced glycation end products (AGE) antibody is described. In order to det...
S. Kume, M. Takeya, T. Mori, N. Araki, H. Suzuki, S. Horiuchi, T. Kodama, Y. Miyauchi, K. Takahashi
American Journal of Pathology   147 654-667   Jan 1995
To elucidate the deposition of advanced glycation end products (AGEs) in aortic atherosclerosis, aortic walls were obtained from 25 autopsy cases and examined immunohistochemically and immunoelectron microscopically with a monoclonal antibody spec...
Satoru Yui, Toshinori Sasaki, Norie Araki, Seikoh Horiuchi, Masatoshi Yamazaki, Masatoshi Yamazaki
Journal of Immunology   152 1943-1949   Feb 1994
We previously showed that negatively-charged phospholipids, acetylated low density lipoprotein (LDL) and oxidized LDL, which are known to be taken up by macrophages via the scavenger receptor for modified LDLs, were able to induce the growth of pe...
Seikoh Oriuchi, Norie Araki
Gerontology   40((suppl2)) 10-15   Jan 1994
Long-term incubation of proteins with glucose leads to advanced glycation end products (AGE). Demonstration of AGE in vivo as well as determination of its main structure are crucial to elucidate its potential link to aging processes and diabetic c...
HORIUCHI Seikoh , ARAKI Norie
Biochemical and Biophysical Research Communications   193(2) 674-680   Jun 1993
The effects of advanced glycation end products (AGE) of the Maillard reaction on proliferation, migration and angiogenesis of cultured human umbilical vein endothlial cells (HUVEC) were studied. In an in vitro angiogenesis system, tube formation o...
Toshio Miyata, Toshio Miyata, Toshio Miyata, Osamu Oda, Reiko Inagi, Yoshiyasu Iida, Norie Araki, Norio Yamada, Seikoh Horiuchi, Naoyuki Taniguchi, Kenji Maeda, Taroh Kinoshita
Journal of Clinical Investigation   92 1243-1252   Jan 1993
β2-Microglobulin (β2M) is a major constituent of amyloid fibrils in hemodialysis-associated amyloidosis, a complication of long-term hemodialysis patients. Amyloid fibril proteins were isolated from connective tissues forming carpal tunnels in hem...
N. Araki, N. Ueno, B. Chakrabarti, Y. Morino, S. Horiuchi
Journal of Biological Chemistry   267 10211-10214   Jan 1992
Prolonged incubation of protein with reducing sugar proceeds through a series of reactions involving early stage products to the advanced glycation end products with fluorescence, brown color, and cross-linking. Known collectively as the Maillard ...
S. Horiuchi, N. Araki, Y. Morino
Journal of Biological Chemistry   266 7329-7332   Jul 1991
Reaction of protein amino groups with glucose (the Maillard reaction) leads from early stage products such as Schiff base and Amadori products to advanced glycation end products (AGE), structures implicated in diabetic complications and the aging ...
Norie Araki, Seikoh Horiuchi, Abu Torab M.A. Rahim, Kyoko Takata, Yoshimasa Morino
Analytical Biochemistry   185(2) 339-345   Jan 1990
A simple and rapid method for the microquantification of cholesterol and cholesteryl esters by reversephase high performance liquid chromatography has been established. Comparison of elution patterns of authentic cholesterol and cholesteryl esters...
MORITSUGU SHINOHARA, MORITSUGU SHINOHARA, ABU TORAB M.A. RAHIM, AKIRA MIYAZAKI, NORIE ARAKI, MOTOAKI SHICHIRI, MOTOAKI SHICHIRI, YOSHIMASA MORINO, SEIKOH HORIUCHI
Annals of the New York Academy of Sciences   598 558-559   Jan 1990
Kyoko Takata, Seikoh Horiuchi, Norie Araki, Masanobu Shiga, Mikihiko, Saitoh, Yoshimasa Morino
BBA - Biomembranes   986 18-26   Nov 1989
Long-term incubation of proteins with glucose undergo a series of nonezymatic reactions to form advanced glycosylation end product (AGE) with fluorescence and brown color. The receptor for AGE-proteins was demonstrated in murine macrophages (Vlass...
Yoshio Haga, Kyoko Takata, Norie Araki, Kiyoshi Sakamoto, Masanobu Akagi, Yoshimasa Morino, Seikoh Horiuchi
Biochemical and Biophysical Research Communications   160(2) 874-880   Apr 1989
Interleukin 1 (IL-1) is a major cytokine of macrophages secreted by several stimulants such as lipopolysaccharide (LPS). Macrophages are known to possess the scavenger receptor for acetylated low density lipoprotein (acetyl-LDL) and maleylated alb...
Seikoh Horiuchi, Kyoko Takata, Norie Araki, Yoshimasa Morino
Journal of Molecular Recognition   2 56-62   Jan 1989
Scavenger receptor‐mediated endocytosis of maleyl‐albumin was studied with rat sinusoidal liver cells. Upon maleylation of > 28 mol lysine residues per protein, bovine serum albumin became an active ligand. Further modification of up to 37 mol lys...
S. Horiuchi, M. Shiga, N. Araki, K. Takata, M. Saitoh, Y. Morino
Journal of Biological Chemistry   263 18821-18826   Dec 1988
The reaction of protein amino groups with glucose leads to the formation of a stable Amadori product via a Schiff base adduct, which is further converted to advanced glycosylation end products (AGE) with color and unique fluorescence characteristi...
K. Takata, S. Horiuchi, N. Araki, M. Shiga, M. Saitoh, Y. Morino
Journal of Biological Chemistry   263 14819-14825   Jan 1988
Long term incubation of proteins with glucose, named the Maillard reaction (Maillard, L. C. (1912) C. R. Acad. Sci. (Paris) 154, 66-68), gives rise to advanced glycosylation end product (AGE) with fluorescence, color, as well as cross-linked prope...

Misc

 
TCTP-EF1A2-翻訳伸長因子複合体を介した神経線維腫症1型腫瘍特異的な翻訳機構の解析
小林 大樹, 徳田 高穂, 岡西 広樹, 大槻 純男, 荒木 令江
生命科学系学会合同年次大会   2017年度 [3LBA-029]   Dec 2017
jPOST プロテオームデータベースの開発
守屋 勇樹, 河野 信, 奥田 修二郎, 渡辺 由, 山本 格, 松本 雅記, 高見 知代, 小林 大樹, 荒木 令江, 吉沢 明康, 田畑 剛, 杉山 直幸, 田中 聡, 五斗 進, 石濱 泰
生命科学系学会合同年次大会   2017年度 [3P-0173]   Dec 2017
jPOST 同定結果のFDR改善を目指す再解析プロトコルの開発
吉沢 明康, 田畑 剛, 守屋 勇樹, 河野 信, 奥田 修二郎, 渡辺 由, 山本 格, 松本 雅記, 高見 知代, 小林 大樹, 荒木 令江, 杉山 直幸, 田中 聡, 五斗 進, 石濱 泰
生命科学系学会合同年次大会   2017年度 [3P-0172]   Dec 2017
jPOST プロテオーム統合データベースプロジェクト
奥田 修二郎, 渡辺 由, 守屋 勇樹, 河野 信, 山本 格, 松本 雅記, 高見 知代, 小林 大樹, 荒木 令江, 吉沢 明康, 田畑 剛, 杉山 直幸, 田中 聡, 五斗 進, 石濱 泰
生命科学系学会合同年次大会   2017年度 [3P-0171]   Dec 2017
細胞分裂の制御に関わるSatellite I ncRNP複合体構成因子候補YB-1の機能解析
河野 貴亮, 井手上 賢, 荒木 令江, 谷 時雄
生命科学系学会合同年次大会   2017年度 [2P-0541]   Dec 2017
融合オミクスによるグリオーマ幹細胞の分化と維持に関わる鍵分子群の同定と機能制御の解析
荒木 令江, 南部 晶子[新堀], シルシリバニット・アチト, 岡西 広樹, 小林 大樹, 秀 拓一郎, 中村 英夫
日本癌学会総会記事   76回 P-2117   Sep 2017
融合的オミクス解析とシステムズバイオロジーによるNF1腫瘍の新規治療ターゲットシグナルの同定と機能解析
荒木 令江, 小林 大樹, 新堀 晶子[南部], 中村 英夫, 尹 浩信, 倉津 純一
日本癌学会総会記事   75回 E-3038   Oct 2016
神経線維腫症1型に関連する腫瘍においてインタラクトーム分析により同定されたTCTPと翻訳伸長因子の新規の相互作用形態(Interactome analysis identified a novel interaction form of TCTP and translaton elongation factors in Neurofibromatosis-type 1-associated tumors)
小林 大樹, 徳田 高穂, 長山 慈, 平山 未央, 大槻 純男, 荒木 令江
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集   88回・38回 [3LBA121]-[3LBA121]   Dec 2015
jPOST プロテオーム解析ワークフローの標準化
守屋 勇樹, 河野 信, 奥田 修二郎, 山本 格, 松本 雅記, 小林 大樹, 荒木 令江, 吉沢 明康, 五斗 進, 田畑 剛, 杉山 直幸, 石濱 泰
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集   88回・38回 [3P0417]-[3P0417]   Dec 2015
セントロメアncRNP複合体によるコヒーシンならびに染色体分離の制御
長 裕紀子, 井手上 賢, 荒木 令江, 谷 時雄
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集   88回・38回 [2T25p-10(2P0767)]   Dec 2015
ARAKI Norie
生物物理化学 = Journal of Electrophoresis   50(3) 217-224   Sep 2006
HIROTA Masahiko, FUJIMURA Yoshinori, ICHIHARA Atsushi, ARAKI Norie, BABA Hideo
Nippon Shokakibyo Gakkai Zasshi   103(8) 918-923   Aug 2006
PARは三量体G蛋白共役型7回膜貫通型のレセプターであり,細胞外のN末端がプロテアーゼによって特異的に切断され,切断されたN末端部(tethered ligand)がPAR自身の細胞外の第二のループに特異的に結合することによって細胞内にシグナルを伝達する.これらのPARは,多種多様な細胞の細胞膜上に発現されており,多くの重要な生体機能の調節に深くかかわっていることが明らかにされている.PAR,中でもPAR-2は生理的に膵腺房細胞,膵管上皮細胞に発現され,また,膵臓にはPAR-2の主アゴニス...
Araki Norie
SEIBUTSU BUTSURI KAGAKU   50(3) 217-224   2006
Recent advances of innovative technologies and valuable data bases for proteome analysis enable us to identify extremely miner but important cellular proteins that related to the pathogenesis, with high throughput and quantitative manner. We estab...
ARAKI Norie, KAWANO Katsumi, TODA Toshihusa, ARAKI Tomohiro, TSUGITA Akira, KIRA Jun-ichi, SAYA Hideyuki
Japanese journal of electrophoresis   47(1) 7-16   Jun 2003
Araki Norie, Kawano Katsumi, Toda Toshihusa, Araki Tomohiro, Tsugita Akira, Kira Jun-ichi, Saya Hideyuki
SEIBUTSU BUTSURI KAGAKU   47(1) 7-16   2003
More than three hundreds of genes related to brain diseases have been identified in human genome analysis. However, there are few information on the gene products (proteins) that give us the most important idea on the biological mechanism of the d...
Norie Araki, Norie Araki, Tadaomi Morimasa, Tomoko Sakai, Hiroshi Tokuoh, Shunji Yunoue, Masaharu Kamo, Kenji Miyazaki, Koji Abe, Hideyuki Saya, Akira Tsugita
Electrophoresis   21(9) 1880-1889   Jul 2000
p53 is a tumor suppressor protein that regulates many cellular processes including the cell cycle, DNA repair, and apoptosis. It also serves as a critical regulator of neuronal apoptosis in the central nervous system (CNS). To elucidate the role o...
Atsuko Abiko, Atsuko Abiko, Masaaki Eto, Masaaki Eto, Isao Makino, Isao Makino, Norie Araki, Norie Araki, Seikoh Horiuchi, Seikoh Horiuchi
Metabolism: Clinical and Experimental   21(9) 1880-1889   Jan 2000
Increased levels of advanced glycosylation end products (AGEs) have been reported in tissues in association with diabetes mellitus. Thus, we measured tissue AGE levels and detected an accumulation of AGEs in the kidney and liver from spontaneously...
Proteomics on cancer research
ARAKI Norie
14(4) 605-611   2000
Kiyoharu Ito, Kiyoharu Ito, Isamu Okamoto, Norie Araki, Yoshiaki Kawano, Mitsuyoshi Nakao, Shigetoshi Fujiyama, Kimio Tomita, Tatsuyuki Mimori, Hideyuki Saya
Oncogene   18(50) 7080-7090   Nov 1999
Cadherins are major cell-cell adhesion molecules in both tumor and normal tissues. Although serum levels of soluble E-cadherin have been shown to be higher in the cancer patients than in healthy volunteers, the detail mechanism regulating release ...
Hiroaki Kuwahara, Hiroaki Kuwahara, Norie Araki, Keishi Makino, Norio Masuko, Shinobu Honda, Shinobu Honda, Kozo Kaibuchi, Kohji Fukunaga, Eishichi Miyamoto, Michio Ogawa, Hideyuki Sayat, Hideyuki Sayat
Journal of Biological Chemistry   274(45) 32204-32214   Nov 1999
The membrane-associated guanylate kinase proteins have been known to interact various membrane receptors with their N-terminal segments designated the PDZ domains and to cluster these receptors at the target site of the cell membrane. NE-dlg/SAP10...
Rie Shibayama, None Araki, Ryoji Nagai, Seikoh Horinchi, Seikoh Horinchi
Diabetes   48(9) 1842-1849   Sep 1999
Prolonged incubation of proteins with reducing sugar produces advanced glycation end products (AGEs), which are implicated as factors for aging and diabetic complications. We previously demonstrated the presence of N(ε)- (carboxymethyl)lysine (CML...
Norio Masuko, Norio Masuko, Keishi Makino, Hiroaki Kuwahara, Kohji Fukunaga, Tamotsu Sudo, Norie Araki, Hideyuki Yamamoto, Yuji Yamada, Eishichi Miyamoto, Hideyuki Saya
Journal of Biological Chemistry   274(9) 5782-5790   Feb 1999
NE-dlg/SAP102, a neuronal and endocrine tissue-specific membrane- associated guanylate kinase family protein, is known to bind to C-terminal ends of N-methyl-D-aspartate receptor 2B (NR2B) through its PDZ (PSD- 95/Dlg/ZO-1) domains. NE-dlg/SAP102 ...
ARAKI Norie, SAYA Hideyuki
Seikagaku   71(2) 43-49   Feb 1999
Cellular signal transduction via the neurofibromatosis type 2 tumor supressor gene product; Merlin.
ARAKI Norie
Seikagaku   71(2) 43-49   1999
Hisashi Koga, Norie Araki, Hideo Takeshima, Toru Nishi, Toru Hirota, Yoriyoshi Kimura, Mitsuyoshi Nakao, Hideyuki Saya
Oncogene   17(7) 801-810   Aug 1998
Neurofibromatosis 2 (NF2) is an inherited disorder characterized by a predisposition to multiple intracranial tumors. The protein encoded by the NF2 gene has striking similarities to ezrin, radixin and moesin (ERM) proteins which link membrane pro...
Yoriyoshi Kimurau, Yoriyoshi Kimurau, Hisashi Koga, Norie Araki, Norifumi Mugita, Naoyuki Fujita, Hideo Takeshima, Tohru Nishi, Tetsumori Yamashima, Takaomi C. Saido, Toshiki Yamasaki, Kouzo Moritake, Hideyuki Saya, Mitsuyoshi Nakao
Nature Medicine   4(8) 915-922   Aug 1998
Neurofibromatosis type 2 (NF2) protein, also known as merlin or schwannomin, is a tumor suppressor, and NF2 is mutated in most schwannomas and meningiomas. Although these tumors are dependent on NF2, some lack detectable NF2 mutations, which indic...
Bård Smedsrød, Jukka Melkko, Norie Araki, Hiroyuki Sano, Seikoh Horiuchi
Biochemical Journal   322 567-573   Mar 1997
Long-term incubation of proteins with glucose leads to the formation of advanced glycation end products (AGE). Physiological aspects of the catabolism of non-enzymically glycated proteins were studied in vivo and in vitro. AGE-modified BSA (AGE-BS...
Naofumi Imai, Shin Ichi Nishi, Yoshiki Suzuki, Ryou Karasawa, Mitsuhiro Ueno, Hisaki Shimada, Shinji Kawashima, Tsukasa Nakamaru, Yoshikazu Miyakawa, Norie Araki, Seikoh Horiuchi, Fumitake Gejyo, Masaaki A. rakawa
Nephron   76 153-160   Jan 1997
We studied the immunohistochemical localization of advanced glycosylation end products (AGEs) in the progression of diabetic nephropathy. Fourteen NIDDM patients with diabetic nephropathy were evaluated: 2 patients with normoalbuminuria, 4 with mi...
NF2(Neurofibromatosis Type2)gene
ARAKI Norie
136-137   1997
Yoji Hamada, Norie Araki, Naoki Koh, Jiro Nakamura, Seikoh Horiuchi, Nigishi Hotta
Biochemical and Biophysical Research Communications   228(2) 539-543   Nov 1996
To clarify roles of intermediate metabolites of the glycolytic pathway and the polyol pathway in nonenzymatic glycation under physiological conditions, we incubated bovine serum albumin with intermediates of both pathways in the micromolar range a...
Hans Peter Hammes, Antje Weiss, Sibylle Hess, Sibylle Hess, Norie Araki, Seikoh Horiuchi, Seikoh Horiuchi, Michael Brownlee, Klaus T. Preissner, Klaus T. Preissner
Laboratory Investigation   75 325-338   Sep 1996
Early diabetic retinopathy is characterized by areas of acellular capillaries and the accumulation of advanced glycation end products (AGE). Endothelial cell maintenance, growth, and migration is regulated by a complex system involving the partiti...
Norie Araki, Takayuki Higashi, Takayuki Higashi, Takashi Mori, Rie Shibayama, Yoshiki Kawabe, Tatsuhiko Kodama, Kiyoshi Takahashi, Motoaki Shichiri, Seikoh Horiuchi
European Journal of Biochemistry   230(2) 408-415   Jan 1995
Modification of proteins by long‐term incubation with glucose leads to the formation of advanced glycation end products (AGE). Recent immunological demonstration of the presence of AGE proteins in several human tissues suggests that they may be in...
S. Horiuchi, T. Higashi, K. Ikeda, T. Saishoji, Y. Jinnouchi, H. Sano, N. Araki
Contributions to nephrology   112 32-41   Jan 1995
Hirofumi Makino, Kenichi Shikata, Kazue Hironaka, Masahiko Kushiro, Yasushi Yamasaki, Hikaru Sugimoto, Zensuke Ota, Norie Araki, Seikoh Horiuchi
Kidney International   48 527-536   Jan 1995
Advanced protein glycation has been proposed as a major factor in the development of diabetic nephropathy. Advanced glycation end products (AGEs) have altered the structure of extracellular matrix component and impaired self association in vitro. ...
Biological Significance of AGE-receptor
ARAKI Norie
27(9) 449-452   1995
β<SUB>2</SUB>-Microglobulin Modified with Advanced glycation End Products Is a Major Component of Hemodialysis-Associated Amyloidosis.
HORIUCHI Seikoh , ARAKI Norie
92(3) 1243-1252   1993
Biochemical topics on advanced glycation end products(AGE)
ARAKI Norie
21(1) 1-9   1993
Biochemistry of advanced glycation end products (AGE) .
ARAKI Norie
Diabetes Frontier,   4 404-409   1993
AGE (advanced glycation end-product) and aging
ARAKI Norie
19 112-117   1993
Advanced Glycalion End Products(AGE)Genarated on Proteins in vivo
ARAKI Norie
Seikagaku   65(8) 902-902   1993
Biological Significance of the Maillard Reaction in Vivo.
ARAKI Norie
Bioscience and Biotechnology   28 353-355   1990
Study for the inner-ear immunology
ARAKI Norie
16 228-230   1985
Study for acidic glycosaminogly cansof middle ear effusions.
ARAKI Norie
16 361-363   1985

Books etc

 
Study for the existense of AGE in vivo and pathophysiological meanings.
1994   
Biochemical studies on the Post-transrational Modification of Proteins by Glycation.
1993   
Advanced Glycation End Products(AGE)in Vivo.
1993   
Biologial Recognition for Advanced Glycation End Products(AGE)of Maillard Reaction by Macrophage Scavenger Receptors.
1992   
Scavenger receptor for advanced glycation end products of Maillard reaction.
1990   
Biological recognition for advanced glycation end Products.
1990   
Scavenger function of hepatic sinusoid cells against chemical modified proteins.
1989   

Conference Activities & Talks

 
Construction of Japan Proteome Standard Repository/Database [Invited]
ARAKI Norie
jPOST   12 Feb 2016   
Extraction and validation of the specific signal network in cancer tissue cells by proteomics-based integrated -omics
ARAKI Norie
14 Dec 2015   
Identification of TCTP-mTOR signaling as a novel biological target for Neurofibromatosis Type 1-associated tumors
Norie Araki Daiki Kobayashi, Hideo Nakamura, Junich Kuratsu
8 Oct 2015   
The frontier of proteomics-based life science and its clinical application.
ARAKI Norie
23 Jul 2015   
Proteome-Centric Approaches to Decipher Biological Functions [Invited]
ARAKI Norie
15th Annual International Proteomics Conference   26 Mar 2015   
Development of a fully automated two-dimensional electrophoresis device, Auto-2D, and its application for the integrated proteomics [Invited]
ARAKI Norie
22 Oct 2014   
Integrated proteomics for niche molecules related to the maintenance and differentiation of glioma initiating cells [Invited]
Norie Araki、Akiko Nambu, Uichi Midorikawa, Daiki Kobayashi, Souhei Mizuguchi, Minako Nagai, Masayo Wilson, Takuichiro Hide, Hdeio Nakamura,, Junichi Kuratsu
27 Sep 2014   
Integrated proteomics for identifying the specific signal networks regulated by post-translational modifications in cancer and cancer stem cel.ls. [Invited]
ARAKI Norie
5th ACGG(Asian Commumnications of Glycobiology and Glycotechnology) International Conference.   14 Oct 2013   
Heterogeneous oral cancer development by competition via HIF-1 alpha signal regulation
2013   
Analysis of the differentiation mechanism of glioma initiating cells by the integrated proteomics
2013   
Integrated proteomics for studying cellular mechanism of neural tumor formation
2011   
The necessity of basic knowledge of cancer research for medical students and its prospective aspect
2010   
An integrated proteomics for studying cellular mechanism of neural tumors
2010   
A standard framework of sequential proteomics for cancer research [Invited]
ARAKI Norie
The 2nd BMB Conference: Biochemistry and Molecular Biology for Regional Sustainable Development   7 May 2009   
An integrated proteomics for studying mechanism of tumor cellular chemo-resistances
2009   
Assembled Proteomics on Brain Tumors [Invited]
ARAKI Norie
Japan-Taiwan Bilateral Proteomics Symposium   4 Dec 2008   
Functional proteomics for the neuronal tumor suppressors. [Invited]
ARAKI Norie
19 Feb 2008   
“Proteomic Approaches on Tumor Related Gene Function in vivo” [Invited]
ARAKI Norie
RGJ - Ph.D. Congress VIII Symposium   20 Apr 2007   
Proteomic approaches on tumor related gene function [Invited]
ARAKI Norie
The 22th International Kumamoto Medical Bioscience Symposium. Asia-Africa International Network Symposium in Kumamoto of JSPS Asia and Afirica Science Platform Program. The 3th Japan-China Cooperative life Science Symposium in Kumamoto.   23 Oct 2006   
Proteomic approaches on tumor related gene function in vivo [Invited]
ARAKI Norie
The RGJ-Symposium SeriesXL: “Molecular and Cellular Biology for Medicine”   23 Jan 2006   
Hisashi Koga, Hisashi Koga, Ichiro Izawa, Norie Araki, Hideyuki Saya, Tatsuyuki Mimori
Microbiology and Immunology   1 Jan 2005   
In this study, we observed the intracellular behavior of recombinant invasin, a 103-kDa outer membrane protein of Yersinia pseudotuberculosis. To mimic the in vivo behavior of bacterial invasin, a polyvalent form of invasin was generated by incuba...
Functional regulation of Neurofibromatosis type I tumor suppressor neurofibromin controls neuronal cellular differentiation via its Ras-GAP related domain [Invited]
ARAKI Norie
The Third Neuroscience Workshop   29 Nov 2002   
STUDY OF AUTOANTIBODY AGAINST ADVANCED GLYCATION ENDPRODUCTS OF THE MAILLARD REACTION, [Invited]
ARAKI Norie
2000   
Scavenger receptor of sinusoidal liver cells for advanced glycosylation end products of the Maillard reaction. [Invited]
ARAKI Norie
The 3th International Symposium of Sinusoidal Liver Cells   1990   
Acidic glycosaminoglycans (mucopoly saccharides) in middle ear effusions. [Invited]
ARAKI Norie
The 3th International Symposium of Otitis Media with Effusions   1985   

Association Memberships

 
JAPAN SOCIETY OF CLINICAL PROTEOGENOMICS , JAPANESE SOCIETY FOR BIOMEDICAL MASS SPECTROMETRY , PROTEIN SCIENCE SOCIETY OF JAPAN , THE JAPANESE CANCER ASSOCIATION , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE BIOCHEMICAL SOCIETY , International Human Proteome Organization , The protein society