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FUJII Noriko

 
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NameFUJII Noriko
e-mailnfujiirri.kyoto-u.ac.jp
AffiliationKyoto University
SectionResearch Reactor Institute, Research Reactor Institute Division of Radiation Life Science
Job titleProfessor,Professor
DegreeDoctor of Medicine
Research funding number90199290

Research Interests

 
crystallin , racemization , Abnormal aggregation of protein , cataract , aging , D-amino acid , Biochemistry

Research Areas

 
  • Biological science / Functional biochemistry / 

Education

 
 
 - 
1980
Graduate School, Division of Medicine, Tokyo Medical and Dental University
 
 
 - 
1974
Faculty of Agriculture, Meiji University
 

Published Papers

 
Identification of Isomeric Aspartate residues in βB2-crystallin from Aged Human Lens.
Takata T, Murakami K, Toyama A, Fujii N.
Biochim Biophys Acta-Proteins and Proteomics.   1866 767-774   2018   [Refereed]
D-Amino acids in protein: The mirror of life as a molecular index of aging.
Fujii N, Takata T, Fujii N, Aki K and Sakaue H.
BBA - Proteins and Proteomics   1866 840-847   2018   [Refereed]
Asp58 modulates lens αA-crystallin oligomer formation and chaperone function.
Takata T, Nakamura-Hirota T, Inoue R, Morishima K, Sato N, Sugiyama M and Fujii N. 
FEBS Journal   285 2263-2277   2018   [Refereed]
Identification of ᴅ-amino acid-containing peptides in human serum.
FUJII Noriko
PLoS ONE   12(12) e0189972   2017   [Refereed]
FUJII Noriko
Glycative Stress Research   4 203-211   2017   [Refereed]
Ferulic Acid Suppresses Amyloid β Production in the Human Lens Epithelial Cell Stimulated with Hydrogen Peroxide.
Nagai N, Kotani S, Mano Y, Ueno A, Ito Y, Kitaba T, Takata T and Fujii N.
BioMed. Res. Int.   2017 5343010   2017   [Refereed]
Isomeric replacement of a single aspartic acid induces a marked change in protein function: The Example of Ribonuclease A.
FUJII Noriko
ACS Omega   2 260-267   2017   [Refereed]
Kim I, Saito T, Fujii N, Kanamoto T and Fujii N.
Amino Acids   48 2855-2866   2016   [Refereed]
Inoue R, Takata T, Fujii N, Ishii K, Uchiyama S, Sato N, Oba Y, Wood K, Kato K, Fujii N & Sugiyama M.
Scientific Reports   6 29208   2016   [Refereed]
FUJII N, Takata T, Fujii N and Aki K.
Biochimica et Biophysica Acta -General Subjects   1860 183-191   2016   [Refereed]
Takata T and Fujii N.
J. Pharm. Biomed Anal.   116 139-144   Jun 2015   [Refereed]
Ramkumar S, Fujii N, Sakaue H, Fujii N, Thankappan B, Kumari RP, Natarajaseenivasan K, Anbarasu K.
Amino Acids.   47 1035-1043   May 2015   [Refereed]
Ramkumar S, Thankappan B, Fujii N, Natarajaseenivasan K, Anbarasu K.
Int. J. Biol. Macromol.   76 102-108   May 2015   [Refereed]
Maeda H, Takata T, Fujii N, Sakaue H, Nirasawa S, Takahashi S, Sasaki H and Fujii N
Anal. Chem   87 561-568   Jan 2015   [Refereed]
Kim I, Saito T, Fujii N, Kanamoto T, Chatake T, Fujii N.
Biochem.Biophys.Res.Commu   466 622-628   2015   [Refereed]
Cataract Formation and Age-Dependent Post-Translational Modifications in Crystallin, The Journal of the Japanese Society for Cataract Research
Fujii N, Takata, T.
The Journal of the Japanese Society for Cataract Research   27 15-18   2015   [Refereed]
Fujii N, Takata, T. and Fujii N.
J. Pharm. Biomed. Anal.   116 25-33   2015   [Refereed]
Sakaue H, Takata T, Fujii N, Sasaki, H and Fujii N.
Biochimica et Biophysica Acta -Proteins and Proteomics   1854 1-9   Nov 2014   [Refereed]
Ono K Fujimoto E, Fujimoto N, Akiyama M, Satoh T, Maeda H, Fujii N, Tajima S 
J Biol Chem.   289 29195-29207   Aug 2014   [Refereed]
Uehara M, Matsuda K, Kato A, Sato S , Shimizu F, Ooatari1 M, Kai Y, Shimada H, Hatano Y, Okamoto O, Katagiri K, Sasaki T, Fujii N, Fujiwara S.
Eur J Dermatol   24 691-693   Jul 2014   [Refereed]
T. Saito; N. Fujii
Radiation Physics and Chemistry   98 57-63   2014   [Refereed]
Comparison of effect of gamma ray irradiation on wild-type and N-terminal mutants of αA-crystallin.
Ramkumar S, Fujii N, Fujii N, Thankappan B, Sakaue H, Ingu K, Natarajaseenivasan K, Anbarasu K.
Molecular Vision   20 1002-1016   2014   [Refereed]
D-amino acid as a biomarker for the photo-aging mechanism.
Fujii N,
Journal of clinical and experimental medicine   248 602-607   2014   [Refereed]
New Analysis of Aspartyl Isomers in Cataractous Lens Proteins
Fujii N and Fujii N.
The Journal of the Japanese Society for Cataract Research   26 33-36   2014   [Refereed]
Y. Miura; S. Harumiya; K. Ono; E. Fujimoto; M. Akiyama; N. Fujii; H. Kawano; H. Wachi; S. Tajima
Experimental Dermatology   22(1) 36-40   Jan 2013   [Refereed]
B. Thankappan; S. Jeyarajan; S. Hiroaki; K. Anbarasu; K. Natarajaseenivasan; N. Fujii
Applied Biochemistry and Biotechnology   170(5) 1184-1193   2013   [Refereed]
S. Cai; T. Saito; N. Fujii
Free Radical Biology and Medicine   65 1037-1046   2013   [Refereed]
N. Numoto; A. Kita; N. Fujii; K. Miki
Biochemical and Biophysical Research Communications   425(3) 601-606   Aug 2012   [Refereed]
Y. Kaji; T. Oshika; Y. Takazawa; M. Fukayama; N. Fujii
British Journal of Ophthalmology   96(8) 1127-1131   Aug 2012   [Refereed]
Structural features of isomerizable aspartyl residues in human α-crystallins
K.-I. Shimizu; A. Kita; N. Fujii; K. Miki
Molecular Vision   18 1823-1827   Jul 2012   [Refereed]
Effects of D-aspartyl residues in structural and functional properties of human lens α-crystallin.
N. Fujii
The Journal of the Japanese Society for Cataract Research   24(1) 5-9   Jun 2012   [Refereed]
FUJII Noriko;FUJII Norihiko;SUGIYAMA Masaaki
Trans Mater Res Soc Jpn   37(2) 131-134   Jun 2012   [Refereed]
Characterization of an antibody that recognizes peptides containing D-β-aspartyl residues
K. Aki; N. Fujii; T. Saito; N. Fujii
Molecular Vision   18 996-1003   Apr 2012   [Refereed]
N. Fujii; N. Fujii
Methods in Molecular Biology   794 325-335   2012   [Refereed]
H. Tamura; N. Ohgami; I. Yajima; M. Iida; K. Ohgami; N. Fujii; H. Itabe; T. Kusudo; H. Yamashita; M. Kato
PLoS ONE   7(6)    2012   [Refereed]
N. Fujii; H. Sakaue; H. Sasaki; N. Fujii
The Journal of biological chemistry   287(47) 39992-40002   2012   [Refereed]
A rapid comprehensive LC-MS based survey of the Asp isomers in crystallins from human cataract lenses.
Norihiko Fujii , Hiroakai Sakaue, Hiroshi Sasaki and Noriko Fujii.
J Biol. Chem.   287 39992-40002   2012   [Refereed]
The study of chemical modification of lens protein for the cataract prevention.
Fujii N and Fujii N.
IOL &RS   26 290-294   2012
The presence and role of D-amino acids in the living organisms. Amino acid Research
N. Fujii
Amino Acid Research   6 19-24   2012
N. Fujii; N. Fujii; T. Kawaguchi; H. Sasaki
Biochemistry   50(40) 8628-8635   Nov 2011   [Refereed]
N. Fujii; Y. Kaji; N. Fujii
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences   879(29) 3141-3147   Nov 2011   [Refereed]
Y. Sadakane; N. Fujii; K. Nakagomi
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences   879(29) 3240-3246   Nov 2011   [Refereed]
Y. Mori; K. Aki; K. Kuge; S. Tajima; N. Yamanaka; Y. Kaji; N. Yamamoto; R. Nagai; H. Yoshii; N. Fujii; M. Watanabe; T. Kinouchi; N. Fujii
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences   879(29) 3303-3309   Nov 2011   [Refereed]
T. Kinouchi; N. Fujii; N. Fujii
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences   879(29) 3349-3352   Nov 2011   [Refereed]
A. Shimada; H. Ozaki; T. Saito; N. Fujii
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences   879(29) 3289-3295   2011   [Refereed]
Clarification of cataract mechanisms-Approach from protein chemistry
N. Fujii
The Journal of the Japanese Society for Cataract Research   (23) 29-32   2011   [Refereed]
High Substrate Selectivity of Mammalian D-Aspartyl Endopeptidase
T. Kinouchi, N. Fujii
KURRI Progress Report 2010   104-104   2011   [Refereed]
N. Fujii; N. Fujii; M. Kida; T. Kinouchi
Amino Acids   39(5) 1393-1399   Nov 2010   [Refereed]
S. Mizukami-Murata; H. Iwahashi; S. Kimura; K. Nojima; Y. Sakurai; T. Saitou; N. Fujii; Y. Murata; S. Suga; K. Kitagawa; K. Tanaka; S. Endo; M. Hoshi
Applied Biochemistry and Biotechnology   162(3) 855-870   Oct 2010   [Refereed]
T. Saito; T. Tezuka; R. Konno; N. Fujii
Japanese Journal of Ophthalmology   54(5) 486-493   Sep 2010   [Refereed]
Y. Yamazaki; N. Fujii; Y. Sadakane; N. Fujii
Analytical Chemistry   82(15) 6384-6394   Aug 2010   [Refereed]
M. Sugiyama; N. Fujii; Y. Morimoto; K. Itoh; K. Mori; T. Fukunaga; N. Fujii
Chemistry and Biodiversity   7(6) 1380-1388   2010   [Refereed]
T. Kinouchi; N. Fujii
Chemistry and Biodiversity   7(6) 1403-1407   2010   [Refereed]
K. Kuge; K. Kitamura; K. Nakaoji; K. Hamada; N. Fujii; T. Saito; N. Fujii
Chemistry and Biodiversity   7(6) 1408-1412   2010   [Refereed]
KAJI Yuichi;OSHIKA Tetsuro;TAKAZAWA Yutaka;FUKAYAMA Masashi;FUJII Noriko
Anti Aging Med (Web)   7(10) 107-111   2010   [Refereed]
E.A. Blakely; N.J. Kleiman; K. Neriishi; G. Chodick; L.T. Chylack; F.A. Cucinotta; A. Minamoto; E. Nakashima; T. Kumagami; T. Kitaoka; T. Kanamoto; Y. Kiuchi; P. Chang; N. Fujii; R.E. Shore
Radiation Research   173(5) 709-717   2010   [Refereed]
H. Br?ckner; N. Fujii
Chemistry and Biodiversity   7(6) 1333-1336   2010   [Refereed]
Y. Kaji; T. Oshika; Y. Takazawa; M. Fukayama; N. Fujii
Chemistry and Biodiversity   7(6) 1364-1370   2010   [Refereed]
N. Fujii; Y. Kaji; N. Fujii; T. Nakamura; R. Motoie; Y. Mori; T. Kinouchi
Chemistry and Biodiversity   7(6) 1389-1397   2010   [Refereed]
T. Kinouchi; A. Matsuda; S. Kawakami; T. Shimizu; T. Shirasawa; N. Fujii
Chemistry and Biodiversity   7(6) 1398-1402   2010   [Refereed]
Relationship between D-amino Acids and Aging
N. Fujii
Gendai Kagaku   466 42-47   2010
3-Dimensional structure observation of mammalian D-aspartyl endopeptidase by high-resolution atomic force microscopy
T. Kinouchi, N. Fujii
KURRI Progress Report 2009   136-136   2010   [Refereed]
D-aspartyl residues occur in proteins with age
N. Fujii
Bioindustry   27 6-12   2010   [Refereed]
D-amino acids and Aging.
N. Fujii
Gendaikagaku   466 42-47   2010   [Refereed]
Y. Kaji; T. Oshika; F. Okamoto; N. Fujii
British Journal of Ophthalmology   93(7) 974-976   Jul 2009   [Refereed]
G. Kashino; S. Fukutani; M. Suzuki; Y. Liu; K. Nagata; S.-I. Masunaga; A. Maruhashi; H. Tanaka; Y. Sakurai; Y. Kinashi; N. Fujii; K. Ono
Journal of Radiation Research   50(4) 377-382   Jul 2009   [Refereed]
Y. Kaji; T. Oshika; Y. Takazawa; M. Fukayama; N. Fujii
British Journal of Ophthalmology   93(7) 977-979   Jul 2009   [Refereed]
A. Shimada; H. Ozaki; T. Saito; F. Noriko
International Journal of Molecular Sciences   10(6) 2578-2590   Jun 2009   [Refereed]
R. Motoie; N. Fujii; S. Tsunoda; K. Nagata; S.-O. Tadashi; T. Kinouchi; N. Fujii; T. Saito; K. Ono
International Journal of Molecular Sciences   10(5) 1999-2009   May 2009   [Refereed]
K. Sakai-Kato; T. Kinouchi; N. Fujii; K. Imai; N. Utsunomiya-Tate
Amino Acids   36(1) 125-129   Jan 2009   [Refereed]
The Formation of D-amino Acids in Protein by UV Irradiation During Aging
N. Fujii
Laboratory animal technology and science   21 31-35   2009
Screening of D-aspartate?containing proteins using the specific proteolytic enzyme、 D-aspartyl endopeptidase
T. Kinouchi, N. Fujii
KURRI Progress Report 2008   140-0   2009   [Refereed]
Large Scale Preparation of Bio-Macromolecules with a Jar-Fermentor System to Deuterium Treatments
T. Chatake, T. Saito, N. Fujii and Y. Morimoto
KURRI Progress Report 2009   0-0   2009
Inversion of amino acids in protein by UV-irradiation and natural aging.
N. Fujii
Laboratory animal technology and science   21 31-35   2009   [Refereed]
N. Fujii; T. Hisano; N. Fujii
Biochimica et Biophysica Acta - Proteins and Proteomics   1784(11) 1507-1513   Nov 2008   [Refereed]
Masaaki Sugiyama, Noriko Fujii, Yukio Morimoto
Neutron network news   18(4) 191-196   Oct 2008   [Refereed]
T. Nakamura; M. Sakai; Y. Sadakane; T. Haga; Y. Goto; T. Kinouchi; T. Saito; N. Fujii
Biochimica et Biophysica Acta - Proteins and Proteomics   1784(9) 1192-1199   Sep 2008   [Refereed]
The Presence of D-amino Acids in the Proteins Obtained from Elderly Donors
N. Fujii and Y. Kaji
Seikagaku   80 287-293   2008
M. Sugiyama; N. Fujii; Y. Morimoto; S. Kurabayashi; M.E. Vigild; T. Nakagawa; T. Sato; K. Itoh; K. Mori; T. Fukunaga
Biomacromolecules   9(2) 431-434   2008   [Refereed]
Recemization of aspartyl residues of proteins in age-related disease
N. Fujii; Y. Kaji
Seikagaku   80(4) 287-293   2008   [Refereed]
The Role of Advanced Glycated End Products (AGE) and D-amino Acids in Eyes during Aging Ophthalmological Practice
Y. Kaji and N. Fujii
Anti Aging Ophthalmology 22 Bunkodo Tsubta K. Edited   164-169   2008
Eye Diseases Induced by Post-translational Modifications of Proteins
N. Fujii and Y. Kaji
Japanese Ophthalmology   79 289-293   2008
New Research of D-amino Acids in Living Body
N. Fujii and H. Homma
Jikken Igaku   26 1278-1284   2008
Racemization of aspartyl residues of proteins in age-related diseases, Frontier Science in Amino Acid and Protein Research
Noriko Fujii and Yuichi Kaji,
SEIKAGAKU   80 287-293   2008   [Refereed]
Ocular diseases related abnormal accumulation of modified proteins
Y. Kaji and N. Fujii
Pharma Medica   28 61-64   2008   [Refereed]
眼の加齢性変化におけるAGEとD-アミノ酸の役割 坪田一男編
Y. Kaji and N. Fujii
Practical ophthalmology ; 22   164-169   2008
ISBN-10: 4830655798
ISBN-13: 978-4830655791
Eye diseases induced by the posttranslational modifications of proteins
藤井紀子
Journal of Japan Ophthalmologists Association   79 289-293   2008   [Refereed]
New development of D- amino acids in living system.
藤井紀子
Experimental Medicine   26 1278-1284   2008   [Refereed]
Y. Kaji; T. Oshika; Y. Takazawa; M. Fukayama; T. Takata; N. Fujii
Investigative Ophthalmology and Visual Science   48(9) 3923-3927   Sep 2007   [Refereed]
M. Sugiyama; N. Fujii; Y. Morimoto; T. Otomo; S. Takata; M. Misawa; M. Annaka; K. Itoh; K. Mori; T. Sato; S. Kurabayashi; T. Fukunaga
Journal of Applied Crystallography   40 S200-S204   Apr 2007   [Refereed]
N. Fujii; T. Nakamura; Y. Sadakane; T. Saito; N. Fujii
Biochimica et Biophysica Acta - Proteins and Proteomics   1774(3) 345-350   Mar 2007   [Refereed]
T. Kinouchi; H. Nishio; Y. Nishiuchi; M. Tsunemi; K. Takada; T. Hamamoto; Y. Kagawa; N. Fujii
Amino Acids   32(1) 79-85   Jan 2007   [Refereed]
N. Fujii; Y. Shimmyo; M. Sakai; Y. Sadakane; T. Nakamura; Y. Morimoto; T. Kinouchi; Y. Goto; K. Lampi
Amino Acids   32(1) 87-94   Jan 2007   [Refereed]
K. Kuge; A. Brack; N. Fujii
Chemistry - A European Journal   13(19) 5617-5621   2007   [Refereed]
D-amino acids: A new frontier in amino acid and protein research - practical methods and protocols
R. Konno; H. Br?ckner; A. D'Aniello; G. Fisher; N. Fujii; H. Homma
D-Amino Acids: A New Frontier in Amino Acid and Protein Research - Practical Methods and Protocols   1-629   2007   [Refereed]
Detection of the specific D-aspartic acid residues in protein
N. Fujii; T. Takata
D-Amino Acids: A New Frontier in Amino Acid and Protein Research - Practical Methods and Protocols   355-367   2007   [Refereed]
紫外線の蛋白質分子への影響
N. Fujii
Photomedicine and photobiology   29th 20   2007   [Refereed]

Books etc

 
The Importance of the Idea of “Parachirality” in Life Science.
Noriko Fujii, Norihiko Fujii, Takumi Takata and Hiroaki Sakaue. (Part:Joint Work)
Elsevier Inc.   2017   ISBN:978-0-12-812824-4
D-Amino acid residues in proteins related to aging and age-related diseases and a new analysis of the isomers in proteins in "D-Amino acids:Physiology, Metabolism and Application"
FUJII Noriko (Part:Joint Work)
Springer   2016   ISBN:978-4-431-56075-3
皮膚蛋白質中のアスパラギン酸残基異性体と紫外線による皮膚老化の関連性
FUJII Noriko (Part:Joint Work, chapter 8)
シーエムシー出版   Apr 2015   
CSJ カレントレビュー17 「極限環境の生体分子―過酷な環境下での機能を科学する」 2014 日本化学会 放射線、紫外線照射、老化によるタンパク質への影響とその分析
FUJII Noriko (Part:Joint Work, 放射線、紫外線照射、老化によるタンパク質への影響とその分析 藤井紀子 )
日本化学会   2014   
Age Related Macular Degeneration - The Recent Advances in Basic Research and Clinical Care.
Yuichi Kaji, Tetsuro Oshika and Noriko Fujii.
InTech   2012   
D-amino-acid-containing proteins in living body--The Soai Reaction and Related Topic
Noriko Fujii, Kenzo Aki and Norhiko Fujii. edited by Gyula P?ly, Claudia Zucchi, Luciano Caglioti.
Accademia Nazionale di Scienze Lettere e Arti Modena、 Italy.   2012   
Experimental studies of chemical evolution using nuclear reactions and their associated radiations and nuclear reactions.
藤井 紀子
"The role of Radiation in the Origin and Evolution of Life". edited by Akaboshi, M. et al. Kyoto Univ. Academic Press, Kyoto,,/,163-173   2000   
Tryptophanase-catalyzed D-tryptophan degradation reaction and its siginificance for chiral homogeneity.
藤井 紀子
"The role of Radiation in the Origin and Evolution of Life. "edited by Akaboshi, M. et al. Kyoto Univ. Academic Press, Kyoto,,/,243-257   2000   
Progress in Biochilarity
Shimada A., Fujii, N., and Saito T.
Elsevier Science   2000   
The role of Radiation in the Origin and Evolution of Life. pp163-173
Akaboshi, M., Kawai, K., Tanaka, Y. Kawamoto, K. and Fujii, N.
Kyoto Univ. Academic Press   2000   
The role of Radiation in the Origin and Evolution of Life. pp243-257
Shimada, A., Shishido, H., Kogure, H., Nakamura, I., Fujii, N. and Akaboshi, M.
Kyoto Univ. Academic Press   2000   
Radiodecomposition of D, L-aspartic acid by tritium-β-rays.
藤井 紀子
"Advanves in Biochilarity", edited by Palyi et. al.,/,387-392   1999   
Spontaneous D-aspartic acid formation at specific sites of lens protein during aging
藤井 紀子
"Advanves in Biochilarity", edited by Palyi et. al.,/,305-313   1999   
Advanves in Biochilarity pp305-313
Fujii, N., Momose Y., and Akaboshi, M.
Elsevier Science   1999   

Conference Activities & Talks

 
生体分子ホモキラリティーのパラダイムシフト − D-アミノ酸研究の新展開
藤井紀子、本間浩
第88回日本生化学会・第37回日本分子生物学会年会合同大会   Dec 2015   
蛋白質異常凝集とD-アミノ酸 (八谷:アミロイド再考) [Invited]
藤井 紀子
第88回日本生化学会・第37回日本分子生物学会年会合同大会   Dec 2015   
Crystallin racemization and insolubilization of lens proteins [Invited]
Noriko Fujii
International Conference on the Lens 2015   Dec 2015   
蛋白質異常凝集とD-アミノ酸 [Invited]
藤井紀子
第88回日本生化学会・第37回日本分子生物学会年会合同大会   Dec 2015   
老化における蛋白質ホモキラリテイーの破れ [Invited]
FUJII Noriko
さきがけ20周年記念講演会 さきがけ研究21「場と領域」研究領域   14 Nov 2015   
「LC-MSを用いた白内障クリスタリン中の異性体アミノ酸の迅速分析法」 [Invited]
藤井紀子
第54回日本白内障学会総会・第41回水晶体研究会 合同開催   18 Sep 2015   
LC-MSを用いた白内障クリスタリン中の異性体アミノ酸の迅速分析法 [Invited]
藤井 紀子
第54回日本白内障学会総会・第41回水晶体研究会   Sep 2015   
The importance of the idea of “Parachirality” in life science [Invited]
Noriko Fujii
3rd International Symposium on the SOAI Reaction and Related Topic   Sep 2015   
LC-MSを用いた皮膚コラーゲン中のD-アスパラギン酸残基の部位の決定
藤井 紀子、鈴木 結
第37回日本光医学・光生物学会   Jul 2015   
Isomerizations of aspartyl residues in lens crystallins from age-related cataracts. [Invited]
FUJII Noriko
Asia-ARVO 2015 Symposium   16 Feb 2015   
Rapid Analysis of D-amino acids in Proteins using LC-MS [Invited]
Noriko Fujii
Origins 2014   6 Jul 2014   
Organising committee
LC-MS/MS による蛋白質中のAsp 異性体の迅速解析 [Invited]
藤井紀子
第15 回日本蛋白質科学会年会   24 Jun 2015   
LC-MS/MS による蛋白質中のAsp 異性体の迅速解析 [Invited]
藤井 紀子
第15 回日本蛋白質科学会年会   Jun 2015   
血液中のD-アミノ酸含有ペプチドの探索
HA SEONGMIN, 高田匠、藤井紀子
第15 回日本蛋白質科学会年会   Jun 2015   
ラット水晶体タンパク質に対するγ線照射の影響
金 仁求、齊藤 毅、金本尚志,藤井 智彦、藤井 紀子
第40回生命の起原および進化学会学術講演会   Mar 2015   
結合型D-アミノ酸形成が誘起する水晶体蛋白質の不溶化
高田匠、藤井紀子
第40回生命の起原および進化学会学術講演会   Mar 2015   
Rapid Analysis of the Isomers of Individual Asp residues in Lens Crystallins from Elderly Donors Using LC-MS [Invited]
Noriko Fujii
International Conference on the Lens   19 Jan 2014   
LC-MSによる結合型D-アミノ酸分析
藤井 紀子、 高田匠、 藤井智彦
第40回生命の起原および進化学会学術講演会   Mar 2015   
放射線照射によるシアル酸(Neu5Ac)の脱炭酸反応生成物ADOAの生成促進
藤井智彦1、飯島亮介2、油井聡2、藤井紀子3、岸本成史
日本薬学会 第135年会   Mar 2015   
ペプチド・蛋白質中の異性化したアスパラギン酸残基の新しい分析方法
藤井智彦1、岸本成史1,2、藤井紀子
日本薬学会 第135年会   Mar 2015   
Isomerizatons of [Invited]
Noriko Fujii, Takumi Takata, Norihiko Fujii, Hiroshi Sasaki
Asia-ARVO 2015 Symposium   16 Feb 2015   
Protein aggregation and racemization of amino acids [Invited]
Noriko FUJII, Norihiko FUJII, Takumi TAKATA, Hiroki MAEDA, Hiroaki SAKAUE
Japan-Hungary Joint Seminar "Mechanism and regulation of aberrant protein aggregation"   18 Nov 2014   
放射線照射によるγークリスタリン中のアミノ酸残基の酸化
金 仁求、高田 匠、齊藤 毅、藤井 智彦、藤井 紀子
第87回日本生化学会   Oct 2014   
LC-MSを用いた皮膚蛋白質中のアスパラギン酸(Asp)残基の異性体分析
鈴木 結、藤井 紀子、坂上 弘明
第87回日本生化学会   Oct 2014   
A new method for the analysis of isomerization of individual Asp residues in proteins using LC-MS. [Invited]
Noriko Fujii
2nd Annual Conference and EXPO of AnalytiX-2013   20 Mar 2013   
Asp異性化がポリペプチド会合体へ及ぼす影響
高田匠、藤井紀子
第87回日本生化学会   Oct 2014   
Analysis of Aspartyl Isomers in Skin Protein by LC-MS/MS.
Yui SUZUKI, Noriko FUJII, Hiroaki SAKAUE
The 2nd International Conference of D-Amino Acid Research IDAR2014   2 Sep 2014   
The Hunt for D-aspartyl endopeptidase in various living things:Vertebrates, Aquatic animals and Plants.
Tadatoshi Kinouchi and Noriko Fujii
The 2nd International Conference of D-Amino Acid Research IDAR2014   2 Sep 2014   
Oxidation and Racemization of Rat Lens Crystallins by gamma Irradiation
Ingu Kim, Takeshi Saito and Noriko Fujii
The 2nd International Conference of D-Amino Acid Research IDAR2014   2 Sep 2014   
Inversion of Aspartyl Residue Disturbs Assembly of Crystallin in Human Cataract Lens.
Hiroaki SAKAUE, Takumi TAKATA, Norihiko FUJII, Hiroshi SASAKI and Noriko FUJII
The 2nd International Conference of D-Amino Acid Research IDAR2014   2 Sep 2014   
Asp Isomerization in Eye Lens Derived Peptide Associated with Pepitde-Pepitde and Peptide _Protein Interactions.
Takumi Takata, Hiroaki Sakaue, Noriko Fujii
The 2nd International Conference of D-Amino Acid Research IDAR2014   2 Sep 2014   
Vice president
水晶体蛋白質のアスパラギン酸残基の異性化と立体構造との関係
藤井 智彦、 岸本 成史、 佐々木 洋、 藤井 紀子
第53回 日本白内障学会総会   Sep 2014   
アスパラギン酸残基の異性化によるクリスタリン会合体の解離
藤井 紀子、 坂上弘明、 高田匠、 藤井智彦、佐々木 洋
第53回 日本白内障学会総会   Sep 2014   
A novel rapid comprehensive analysis of D-amino acids in cataract lens proteins using LC-MS [Invited]
Noriko Fujii
The 2nd International Conference of D-Amino Acid Research IDAR2014   Sep 2014   
Abnormal protein aggregation due to the presence of D-aspartyl residues in cataractous lenses. [Invited]
Noriko Fujii, Norihiko Fujii and Masaaki Sugiyama
12th Annual Meeting of International Union of Materials Research Societies (IUMRS) - International Conference in Asia (ICA)   19 Sep 2011   
Deamidations In β-crystallin Family Are Highly Correlated With Lens Insolubulization During Aging
T. Takata, N. Fujii, K. Lampi.
第14 回日本蛋白質科学会年会   Jun 2014   
老化や酸化ストレスによるD-アミノ酸含有蛋白質の蓄積 [Invited]
藤井紀子
第14回 日本抗加齢医学会総会   Jun 2014   
加齢性眼疾患における蛋白質の変化をとらえる化学的アプローチ [Invited]
藤井紀子
第118回日本眼科学会総会   Apr 2014   
LC-MSを用いた皮膚蛋白質中のアスパラギン酸(Asp)残基の異性体分析
鈴木 結、坂上 弘明、藤井 紀子
生命の起原および進化学会第 39回 学術講演会   Mar 2014   
γ線照射によるγ-クリスタリン中のアミノ酸残基の酸化
金仁求、高田匠、齊藤剛、藤井智彦、 金本尚志、藤井紀子
生命の起原および進化学会第 39回 学術講演会   Mar 2014   
放射線照射による蛋白質への影響 [Invited]
藤井紀子
シンポジウム「宇宙にひろがる人類文明の未来」   Feb 2014   
D−アスパラギン酸が惹起する蛋白質の異常凝集と加齢性疾患 [Invited]
藤井紀子
ビタミン B 研究委員会 平成25年度シンポジウム   31 Jan 2014   
脱アミド化が引き起こすβB1-βA3クリスタリン分子間相互作用変化
高田匠, Kirsten Lampi, 藤井紀子
第40回 水晶体研究会   Jan 2014   
水晶体構成タンパク質中のアスパラギン酸の異性化と立体構造の関係
藤井 智彦、佐々木 洋、藤井 紀子
第40回 水晶体研究会   Jan 2014   
βB2-クリスタリンC末端Asn残基の異性化が引き起こす同一分子間相互作用変化
西岡紀理、藤井智彦、高田匠、藤井紀子
第40回 水晶体研究会   Jan 2014   
放射線照射による水晶体クリスタリンの構造機能変化とAsp異性体の一斉解析、シンポ名:「放射線と水晶体」 [Invited]
藤井紀子
第67回日本臨床眼科学会総会シンポジウム   31 Oct 2013   
白内障患者の水晶体蛋白質に生じている化学変化をとらえる定量的アプローチ [Invited]
藤井紀子
TRF研究会   30 Oct 2013   
LC-MSを用いたタンパク質中のDアスパラギン酸残基の新しい分析方法 
藤井智彦、藤井紀子
第9回D-アミノ酸研究会学術講演会   Sep 2013   
紫外線による皮膚コラーゲン中のアミノ酸の異性化
鈴木結、坂上弘明、藤井紀子
第9回D-アミノ酸研究会学術講演会   Sep 2013   
ヒト扁桃におけるアスパラギン残基の脱アミドおよびアスパラギン酸残基の異性
前田裕貴、藤井智彦、高橋裕一、藤井紀子
第9回D-アミノ酸研究会学術講演会   Sep 2013   
αAクリスタリンの部分ペプチドを用いたAsp異性化シミュレーション 
安岐 健三 、藤井紀子
第86回日本生化学会大会   Sep 2013   
The effects of gamma irradiation on lens proteins of human alpha A- and alpha B-cyrstallins
Norihiko. Fujii1, Tamao. Hisano2, Takeshi. Saito1, & Noriko. Fujii
XVIII International Congress of Eye Research   24 Sep 2008   
Effect of primary and higher order structures on the racemization of Asp 58 and Asp 151 in alpha A-crystallin [Invited]
N. Fujii and T. Nakamura
XVIII International Congress of Eye Research   24 Sep 2008   
加齢、紫外線、電離放射線による水晶体蛋白質の変化 (16:50-17:20)講演 [Invited]
藤井紀子
文部科学省復興対策特別人材育成事業「被ばくの瞬間から生涯を見渡す放射線生物・医学の学際教育」   25 Aug 2013   
蛋白質の異常凝集 (8/24、16:30-17:30)講義 [Invited]
藤井紀子
文部科学省復興対策特別人材育成事業「被ばくの瞬間から生涯を見渡す放射線生物・医学の学際教育」   24 Aug 2013   
蛋白質の異常凝集 
藤井 紀子
文部科学省復興対策特別人材育成事業「被ばくの瞬間から生涯を見渡す放射線生物・医学の学際教育」   Aug 2013   
加齢、紫外線、電離放射線による水晶体蛋白質の変化
藤井 紀子
文部科学省復興対策特別人材育成事業「被ばくの瞬間から生涯を見渡す放射線生物・医学の学際教育」   Aug 2013   
紫外線照射によるペプチド中のトリプトファン残基の酸化とアスパラギン酸残基の異性化の関係
藤井紀子、蔡思敏、藤井智彦
第35回 日本光医学光生物学会    Jul 2013   
LC-MSによる白内障の水晶体蛋白質中のアスパラギン酸残基の異性体の分析 [Invited]
藤井紀子、藤井智彦
第52回 日本白内障学会総会   27 Jun 2013   
Structural investigation of βB2 crystallin and its complex in an aqueous solution. 2
Masaki Sugiyama, Norihiko Fujii and Noriko Fujii.
XX Biennial Meeting of the International Society for Eye Research (ISER 2012)   21 Jul 2012   
The dissociation of a-crystallin-aggregate due to a specific D-Asp residue in αB-crystallin.
XX Biennial Meeting of the International Society for Eye Research (ISER 2012)   21 Jul 2012   
Characterization of alpha-crystallin aggregates from human eye lenses and recombinant human alpha A- and alpha B -crystallins aggregates. [Invited]
Noriko Fujii, Yoshiari Shimmyo, Masaaki Sugiyama, Miyo Sakai, Yutaka Sadakane, Tooru Nakamura, Sakie Kurabayashi, Yukio Morimoto, Masahiko Annaka , Tadatoshi Kinouchi, Yuji Goto and Kirsten Lampi
XVII International Congress of Eye Research   29 Oct 2006   
Identification of β-aspartic acid residues in protein by MALD-TOFMS.
Norihiko Fujii, Yuzo Yamazaki and Noriko Fujii
XX Biennial Meeting of the International Society for Eye Research (ISER 2012)   21 Jul 2012   
Simultaneous inversion and isomerization of Asp residues at N-and C-terminal regions in _B2-crystallin from the aged human cataractous lenses.
Noriko Fujii, Tomohiro Minooka, Norihiko Fujii, Takehiro Kawaguchi and Hiroshi Sasaki.
XX Biennial Meeting of the International Society for Eye Research (ISER 2012)   21 Jul 2012   
Simultaneous isomerization at the Asp-4 residue in βB2-crystallin from the aged human eye lenses
Norihiko Fujii,Takehiro Kawaguchi, Hiroshi Sasaki and Noriko Fujii
International Conference on the Lens   15 Jan 2012   
Quality control of damaged mitochondrial proteins by D-aspartyl endopeptidase.
Kinouchi Tadatoshi and Noriko Fujii
7th Conference of Asian Society for Mitochondrial Research and Medicine (ASMRM) and 10th Conference of Japanese Society of Mitochondrial Research and Medicine   16 Dec 2010   
THE ASP ISOMERS AFFECT THE PROPERTIES OF aA-CRYSTALLIN MIMIC PEPTIDE
Noriko Fujii, Norihiko Fujii, Masashi Kida and Tadatoshi Kinouchi
XIX Biennial Meeting of the International Society for Eye Research (ISER 2010)   18 Jul 2010   
Differentiating alpha- and beta-aspartic acids by MALDI and PSD on Curved Field Reflectron
Yuzo Yamazaki1, Norihiko Fujii2 and Noriko Fujii2
18th International Mass Spectrometry Conference,   30 Aug 2009   
PROTECTION EFFECTS BY METALLOTHIONEIN IN MOUSE LENS EPITHELIAL CELL
Takeshi Saito, Tomoyuki Tezuka, Ryuichi Konno, Noriko Fujii
International Symposium on Origins of Life and Astrobiology30th SSOEL-JAPAN MEETING ISOLAB’05   27 Jun 2005   
KINETIC STUDY OF RACEMIZATION OF ASPARTYL RESIDUES IN MODEL PEPTIDES CORRESPONDING TO SECTIONS OF ELASTIN.
Katsunori Kuge, Shingo Tajima and Noriko Fujii
International Symposium on Origins of Life and Astrobiology30th SSOEL-JAPAN MEETING ISOLAB’05   27 Jun 2005   
CHARACTERIZATION OF NEW D-BETA-ASPARTATE CONTAINING PROTEINS IN A LENS-DERIVED CELL LINE
Takumi Takata, Tadashi Shimo-Oka ,Kunio Miki and Noriko Fujii
International Symposium on Origins of Life and Astrobiology30th SSOEL-JAPAN MEETING ISOLAB’05   27 Jun 2005   
Mammalian D-aspartyl endopeptidase: a scavenger for noxious racemized proteins in aging.
Tadatoshi Kinouchi, Toshiro Hamamoto, Yasuo Kagawa and Noriko Fujii
International Symposium on Origins of Life and Astrobiology30th SSOEL-JAPAN MEETING ISOLAB’05   27 Jun 2005   
Spontaneous D-amino acid Formation in Protein from Elderly Human Tissues. [Invited]
Noriko Fujii, Katsunori Kuge, Ryota Motoie, Tadashi ShimoOka and Shingo Tajima
2005 Isolab   27 Jun 2005   
Simultaneous racemization and glycation of amino acid residues in proteins in UVB irradiated skin
Yuhei Mori, Kenzo Aki, Tadatoshi Kinouchi, TakehiroKawaguti , Masashi Kida , Hiroaki Sakaue , Noriko Fujii
the First International Congress of D-Amino Acid Research   1 Jul 2009   
Substrate specificity and properties of mammalian D-aspartyl endpeptidase
Tadatoshi Kinouchi, Takeshi Saito and Noriko Fujii
the First International Congress of D-Amino Acid Research   1 Jul 2009   

Research Grants & Projects

 
D-amino acid and aging
Project Year: 1994   
The simultaveous stereoinversion and isomerization of Asp residue in crystallin
Project Year: 1994   
UV Radiation and D-amino Acid in Skin
Project Year: 2000