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松島 綾美

 
アバター
研究者氏名松島 綾美
 
マツシマ アヤミ
URLhttp://lsfb.scc.kyushu-u.ac.jp/
所属九州大学
部署大学院理学研究院化学部門 構造機能生化学研究室
職名准教授
学位博士(理学)(九州大学)

研究キーワード

 
核内受容体 , エストロゲン受容体 , オピオイド受容体 , 環境化学物質 , ペプチド , 受容体化学 , ビスフェノール

研究分野

 
  • 環境学 / 放射線・化学物質影響科学 / 
  • 生体分子科学 / 生物分子化学 / 
  • 生物科学 / 構造生物化学 / 
  • 複合化学 / 生体関連化学 / 
  • 境界医学 / 疼痛学 / 
  • 生物科学 / 機能生物化学 / 

経歴

 
2012年4月
 - 
現在
九州大学大学院理学研究院化学部門准教授
 
2009年7月
 - 
2010年1月
特定国派遣研究者(カナダ)
 
2005年2月
 - 
2012年3月
九州大学大学院理学研究院化学部門助手(2014より助教))
 
2004年4月
 - 
2005年1月
日本学術振興会特別研究員PD
 
2001年
 - 
2003年
学術振興会特別研究員DC1
 

学歴

 
 
 - 
2004年
九州大学 理学研究科 分子科学専攻
 
 
 - 
1999年
九州大学 理学部 化学科
 

委員歴

 
2014年
 - 
現在
日本生化学会九州支部評議員
 
2018年
 - 
現在
日本ペプチド学会第15期評議員
 
2018年
 - 
現在
環境ホルモン学会評議員
 
2018年
 - 
現在
DV-Xa研究会常任幹事
 
2014年3月
 - 
2015年2月
日本化学会九州支部会計幹事
 

受賞

 
2016年
科研費審査委員表彰
 
2016年
日本化学会女性化学者奨励賞
 
2015年
日本生化学会奨励賞
 
2011年
日本生化学会-欧文誌論文賞
 
2011年
文部科学大臣表彰若手科学者賞(科学技術分野)
 

論文

 
Ayami Matsushima
International Journal of Molecular Sciences   19    2018年5月
© 2018 by the author. Licensee MDPI, Basel, Switzerland. Huge numbers of chemicals are released uncontrolled into the environment and some of these chemicals induce unwanted biological effects, both on wildlife and humans. One class of these chemi...
LIU Xiaohui, 松島綾美, 下東康幸
月刊細胞   49(7) 363‐367   2017年6月
Xiaohui Liu, Hirokazu Nishimura, Akina Fujiyama, Ayami Matsushima, Miki Shimohigashi, Yasuyuki Shimohigashi
Biopolymers   547-554   2016年11月
© 2015 Wiley Periodicals, Inc. Estrogen-related receptor γ (ERRγ) is a constitutively active nuclear receptor functioning as a transcription factor. ERRγ binds to a single half site designated as ERRE that has only a single DNA-binding motif. Howe...
Ayami Matsushima, Hirokazu Nishimura, Yutaka Matsuyama, Xiaohui Liu, Tommaso Costa, Yasuyuki Shimohigashi
Biopolymers   460-469   2016年11月
© 2016 Wiley Periodicals, Inc. We previously showed that an antagonist-based peptide ligand, H-Cys(Npys)-Arg-Tyr-Tyr-Arg- Ile-Lys-NH2, captures the free thiol groups in the ligand-binding site of the nociceptin receptor ORL1. However, the exact re...
Shogo Inamine, Hirokazu Nishimura, Jinglan Li, Kaname Isozaki, Ayami Matsushima, Tommaso Costa, Yasuyuki Shimohigashi
Bioorganic and Medicinal Chemistry   22 5902-5909   2014年11月
© 2014 Elsevier Ltd. All rights reserved. IsoVa-RYYRIK-NH2is a highly specific antagonist ligand of the opioid receptor-like 1 (ORL1) receptor, an endogenous ligand of which is 17-mer peptide nociceptin. ORL1 antagonists have potential for clinica...
Jinglan Li, Hirokazu Nishimura, Ayami Matsushima, Yasuyuki Shimohigashi
Bioorganic and Medicinal Chemistry   22 5721-5726   2014年11月
© 2014 Elsevier Ltd. All rights reserved. Antagonists of the neuropeptide nociceptin are expected to be potential analgesic and antineuropathic drugs acting on ORL1 GPCR receptors. The peptide library-based antagonist Ac-RYYRIK-NH2inhibits the noc...
Xiaohui Liu, Ayami Matsushima, Miki Shimohigashi, Yasuyuki Shimohigashi
PLoS ONE   9    2014年6月
The endocrine disruptor bisphenol A (BPA) affects various genes and hormones even at merely physiological levels. We recently demonstrated that BPA binds strongly to human nuclear receptor estrogen-related receptor (ERR) γ and that the phenol-A gr...
下東康幸, LIU X., 松島綾美
Endocr Disrupter News Lett   15(4) 5   2013年3月
Ayami Matsushima, Kerrianne Ryan, Yasuyuki Shimohigashi, Ian A. Meinertzhagen
Environ. Pollut.   173 257-263   2013年2月   [査読有り]
Bisphenol A (BPA) is widely used industrially to produce polycarbonate plastics and epoxy resins. Numerous studies document the harmful effects caused by low-dose BPA exposure especially on nervous systems and behavior in experimental animals such...
Liu X, Matsushima A, Nakamura M, Costa T, Nose T, Shimohigashi Y
J. Biochem.   151 403-415   2012年4月   [査読有り]
Various lines of evidence have shown that bisphenol A (BPA) acts as an endocrine disruptor that affects various hormones even at merely physiological levels. We demonstrated recently that BPA binds strongly to human nuclear receptor estrogen-relat...
Matsushima, A., Nishimura, H., Inamine, S., Uemura, S., Shimohigashi, Y.
Bioorg. Med. Chem.   19(24) 7597-7602   2011年12月   [査読有り]
All of the δ, μ, and κ opioid receptors have a free thiol group of the Cys residue in the ligand-binding site, although its functional role is not yet known. In order to examine whether or not a similar Cys is also present in the ORL1 nociceptin r...
Arase, S., Ishii, K., Igarashi, K., Aisaki, K., Yoshio, Y., Matsushima, A., Shimohigashi ,Y., Arima, K., Kanno, J., Sugimura, Y.
Bio. Reprod.   84 734-742   2011年4月   [査読有り]
The balance between androgens and estrogens is very important in the development of the prostate, and even small changes in estrogen levels, including those of estrogen-mimicking chemicals, can lead to serious changes. Bisphenol A (BPA), an endocr...
Hassaneen, E., El-Din Sallam, A., Abo-Ghalia, A., Moriyama, Y., Karpova, S.G., Abdelsalam, S., Matsushima, A., Shimohigashi, Y., and Tomioka, K.
J. Biol. Rhythm   26 3-13   2011年2月   [査読有り]
Pigment-dispersing factor (PDF) is a neuropeptide widely distributed in insect brains and plays important roles in the circadian system. In this study, we used RNA interference to study the role of the pigment-dispersing factor (pdf) gene in regul...
Liu, X., Matsushima, A., Okada, H., and Shimohigashi, Y.
J. Biochem   148(2) 247-254   2011年   [査読有り]
Bisphenol A (BPA) strongly binds to human estrogen-related receptor γ (ERRγ). BPA is an oestrogenic endocrine disruptor that influences various physiological functions at very low doses. BPA functions as an inverse-type antagonist of ERRγ to retai...
Matsushima, A., Liu, X., Okada, H., Shimohigashi, M., and Shimohigashi, Y
Environ. Health Perspect.   118(9) 1267-1272   2010年9月   [査読有り]
Background: Bisphenol AF has been acknowledged to be useful for the production of CF3-containing polymers with improved chemical, thermal, and mechanical properties. Because of the lack of adequate toxicity data, bisphenol AF has been nominated fo...
Isozaki, K., Li, J., Okada, K., Nishimura H., Matsushima, A., Nose, T., Costa, T., Shimohigashi, Y.
Bioorg. Med. Chem.,   17 7904-7908   2009年12月
[Arg14,Lys15]Nociceptin is a very potent for ORL1 receptor, showing a few times stronger binding activity and much more enhanced biological activity than endogenous nociceptin. This synergistic outcome has been suggested to be due to the interacti...
Nishimura, H., Li, J., Isozaki, K., Okada, K., Matsushima, A., Nose, T., Costa, T., and Shimohigashi, Y.
Bioorg. Med. Chem.,   17, 5683-5687   2009年8月
ORL1 is an endogenous G protein-coupled receptor for neuropeptide nociceptin. [(R/K)14, (R/K)15]nociceptin is a superagonist that strongly activates the ORL1 receptor. We have previously found that substituting with Trp can reproduce the potentiat...
Takeda, Y., Liu, X., Sumiyoshi, M., Matsushima, A., Shimohigashi, M., and Shimohigashi, Y.
J. Biochem.,   146(1) 113-122   2009年7月
Estrogen-related receptor γ (ERRγ), one of the 48 human nuclear receptors, has a fully active conformation with no ligand. We recently demonstrated that ERRγ binds strongly bisphenol A (BPA), one of the nastiest endocrine disruptors, and thus reta...
Kazushi Okada, Kaname Isozaki, Jinglan Li, Ayami Matsushima, Takeru Nose, Tommaso Costa, Yasuyuki Shimohigashi
Bioorganic and Medicinal Chemistry   16 9261-9267   2008年10月
Nociceptin is an endogenous ligand that activates a G protein-coupled receptor ORL1 and contains two indispensable Arg-Lys (RK) dipeptide units at positions 8-9 and 12-13. By replacing an additional RK unit at positions 6-7, 10-11, 14-15, or 16-17...
Yokotani, S., Nose, T., Horiuchi, Y., Matsushima, A., and Shimohigashi, Y.
Protein Peptide Sci.   15 949-955   2008年9月
Analysis of the amino acid composition of prion protein using a newly developed program for radar-chart deviation analysis has identified an abnormality or irregularity of the N-terminal flexible domain. Aromatic amino acids Trp and His together w...
Matsushima. A., Teramoto, T., Okada, H., Liu, X., Tokunaga, T., Kakuta, Y., and Shimohigashi, Y.
Biochem. Biophys. Res. Commun.   373(3) 408-413   2008年8月
A receptor-binding assay and X-ray crystal structure analysis demonstrated that the endocrine disruptor bisphenol A (BPA) strongly binds to human estrogen-related receptor γ (ERRγ). BPA is well anchored to the ligand-binding pocket, forming hydrog...
Jinglan Li, Kaname Isozaki, Kazushi Okada, Ayami Matsushima, Takeru Nose, Tommaso Costa, Yasuyuki Shimohigashi
Bioorganic and Medicinal Chemistry   16 2635-2644   2008年3月
Nociceptin is an endogenous agonist ligand of the ORL1 (opioid receptor-like 1) receptor, and its antagonist is a potential target of therapeutics for analgesic and antineuropathy drugs. Ac-RYYRIK-NH2is a hexapeptide isolated from the peptide libr...
Okada, H., Tokunaga, T., Lui, X., Takayanagi, S., Matsushima, A., and Shimohigashi, Y.
Environ. Health Perspect.   116 32-38   2008年1月
Background: Various lines of evidence have shown that bisphenol A [BPA; HO-C6H4-C(CH3)2- C6H4-OH] acts as an endocrine disruptor when present in very low doses. We have recently demonstrated that BPA binds strongly to human estrogen-related recept...
Design Synthesis of Highly Potent Antagonist of ORL1 Nociceptin Receptor.
Li, J. Isozaki, K., Okada, K., Matsushima, A., Nose, T., Costa, T., and Shimohigashi, Y.
Bioorg. Med. Chem.      2008年
Liu, X., Matsushima, A., Okada, H., Tokunaga, T., Isozaki, K., and Shimohigashi, Y.
FEBS J.   274 6340-6351   2007年12月
Bisphenol A, 2,2-bis(4-hydroxyphenyl)propane, is an estrogenic endocrine disruptor that influences various physiological functions at very low doses, even though bisphenol A itself is ineffectual as a ligand for the estrogen receptor. We recently ...
Matsushima, A., Kakuta, Y., Teramoto, T., Koshiba, T., Liu, X., Okada, H., Tokunaga, T., Kawabata, S., Kimura, M., and Shimohigashi, Y.
J. Biochem.   142(4) 517-524   2007年10月
Many lines of evidence reveal that bisphenol A (BPA) functions at very low doses as an endocrine disruptor. The human estrogen-related receptor γ (ERRγ) behaves as a constitutive activator of transcription, although the endogenous ligand is unknow...
Matsushima, A., Takano, K., Yoshida, T., Takeda, Y., Yokotani, S., Shimohigashi, Y., and Shimohigashi, M.
J. Biochem   141(6) 867-877   2007年6月
Many lines of evidence have suggested that neuropeptides other than pigment-dispersing factor (PDF) are involved in regulating insect circadian rhythms, and FMRFamide-related peptides are additional candidates acting as such neuromodulators. Doubl...
Takayanagi, S., Tokunaga, T., Liu, X., Okada, H., Matsushima, A., and Shimohigashi, Y.
Toxicol. Lett.   167 95-105   2006年12月
Bisphenol A (BPA) has been acknowledged as an estrogenic chemical able to interact with human estrogen receptors (ER). Many lines of evidence reveal that BPA has an impact as an endocrine disruptor even at low doses. However, its binding to ER and...
Honda, T., Matsushima A., Sumida K., Chuman Y., Sakaguchi K., Onoue H., Meinertzhagen I.A., Shimohigashi Y., and Shimohigashi, M.
J. Comp. Neurol.   499 404-421   2006年11月
Pigment-dispersing factor (PDF) is an 18-mer peptide that acts as a principal neurotransmitter of the insect circadian clock. Our previous study, utilizing anti-Uca β-PDH polyclonal antibody (pAb) to immunolabel the optic lobe of the cricket Gryll...
Molecular Cloning and Circadian Expression Profile of Pacemaker Neuropeptide PDF in Diptera
Matsushima, S., Yokotani, S., Sato, S., Kaneki, A., Takeda, Y., Chuman, Y., Ozaki, M., Asai, D., Nose, T., Onoue, H., Ito, Y., Tominaga, Y., Shimohigashi, Y., and Shimohigashi, M.
Lett., Peptide Sci.      2005年
Y. Takeda, Y. Chuman, N. Shirasu, S. Sato, A. Matsushima, A. Kaneki, Y. Tominaga, Y. Shimohigashi, and M. Shimohigashi
Zool. Sci.   21 903-915   2005年
The molecular basis of the circadian clock is an autoregulatory feedback loop in which the PAS domain-containing protein PERIOD periodically inhibits its own transcription. In the present study on PERIOD of the silk moth Bombyx mori, we have clone...
A. Matsushima, S. Sato, Y. Chuman, Y. Takeda, S. Yokotani, T. Nose, Y. Tominaga, M. Shimohigashi, and Y. Shimohigashi
J. Peptide Sci.   10 82-91   2004年2月
Pigment-dispersing factor (PDF), an 18-amino acid neuropeptide, is a principal circadian neurotransmitter for the circadian rhythms of the locomotor activity in flies. Recently, two completely different types of PDF precursor were clarified; that ...
Ayami Matsushima, Satoru Yokotani, Xiaohui Lui, Kazunori Sumida, Takeshi Honda, Seiji Sato, Atsushi Kaneki, Yukimasa Takeda, Yoshiro Chuman, Yoshiro Chuman, Mamiko Ozaki, Daisuke Asai, Takeru Nose, Hitoshi Onoue, Yushi Ito, Yoshiya Tominaga, Yasuyuki Shimohigashi, Miki Shimohigashi
Letters in Peptide Science   10 419-430   2003年11月
Pigment-dispersing factor PDF is an 18-amino acid insect neuropeptide that mediates a circadian rhythmicity in locomotor activity. PDF is coded in a precursor protein together with another neuropeptide named PDF-associated peptide, PAP. PDF is hig...
Soto, S., Chuman, Y., Matsushima, A., Tominaga, K., Shimohigashi, Y., and Shimohigashi, M.
Zool. Sci.   19(8) 821-828   2002年8月
Pigment-dispersing factor (PDF), an 18-amino acid neuropeptide, is a principal circadian neuromodulator functioning downstream of the insect brain's circadian clock, modulating daily rhythms of locomotor activity. Recently, we found that PDF precu...
Chuman, Y., Matsushima, A., Sato, S., Tomioka, K., Tominaga, Y., Meinertzhagen, I.A., Shimohigashi, Y., and Shimohigashi, M.
J., Biochem.   131 895-903   2002年1月
Pigment-dispersing factor (PDF) was recently reported to be a principal circadian neuromodulator involved in transmitting circadian rhythms of daily locomotion in insects. In Drosophila, PDF functions in some of the neurons expressing the clock ge...
松島綾美、下東康幸、下東美樹
比較生理生化学   18(3) 159-166   2002年
Matsushima, A., Fujita, T., Okada, K., Shirasu, N., Nose, T., and Shimohigashi, Y.
Bull. Chem. Soc. Jpn   73(11) 2531-2538   2000年11月
The thrombin receptor-tethered ligand SFLLRNP (abbreviation formed by one letter amino acid codes expressing Ser-Phe-Leu-Leu-Arg-Asn-Pro) consists of the Phe-2 residue essential for the receptor activation. In order to explore the molecular charac...
Fujita, T., Nose, T., Matsushima, A., Okada, K., Asai, D., Yamauchi, Y., Shirasu, N., Honda, T., Shigehiro, D., and Shimohigashi, Y.
Tetrahedron Letters   41(6) 923-927   2000年2月
A complete set of difluorophenylalanines in the L-configuration [L- (F2)Phe] (namely, L-(2,3-F2)Phe, L-(2,4-F2)Phe, L-(2,5-F2)Phe, L-(2,6- F2)Phe, L-(3,4-F2)Phe, L-(3,5-F2)Phe) was prepared and incorporated into the thrombin receptor-tethered liga...
A. Matsushima, T. Fujita, T. Nose, Y. Shimohigashi
Journal of Biochemistry   128 225-232   2000年1月
In the ligand/receptor interaction, the side chain phenyl group of phenylalanine (Phe) is involved in a so-called hydrophobic interaction, in which the Phe-phenyl group functions as a π element or merely as a hydrophobic element. The thrombin rece...

Misc

 
Phe 2715.39 of Thronbin Receptor PAR-1 is a specific target of Phe-2-phenl group of its tethered ligand
Sugiyama, M., Fujita, T., Liu, X., Yutaka, M., Matsushima, A., Shimohigashi, M., and Shimohigashi, Y.
Peptide Science 2017      2018年   [査読有り]
Mutual co-work between nuclear receptor ER and ERR requires their homodimerization
Liu, X., Shimohigashi, M., Sugiyama, M., Matsushima, A., and Shimohigashi, Y.
Peptide Science 2017      2018年   [査読有り]
Homodimer function of human nuclear receptor ERR evidenced using -helix peptides in the dimer interface
Liu, X., Nakagawa, H., Sugiyama, M., Matsushima, A., Shimohigashi, M., and Shimohigashi, Y.
Peptide Science 2017      2018年   [査読有り]
SCN Circadian Rhythm Signal Transduction Neuropeptides Evoke Hypoactive Phenotype Differently in Male and Female Mice.
Sugiyama, M., Motomatsu, Y., Matsuyama, Y., Kajiyama, S., Kameda, T., Saito, T., Uchimura, E., Liu, X., Matsushima, A., and Shimohigashi. Y.
Peptide Science 2015      2016年   [査読有り]
ORL1 Nociceptin Receptor Response of Opioid Peptides Derived from Proenkephalin Precursor Protein.
Motomatsu, Y., Nishimura, H., Matsusyama, Y., Liu, X., Matsushima, A., and Shimohigashi. Y.
Peptide Science 2015      2016年   [査読有り]
Functional Role of the Phe-Phe Stacking Microswitch in the ORL1 Nociceptin Receptor Activation.
Takesue, Y., Nishimura, H., Liu, X., Matsushima, A., and Shimohigashi. Y.
Peptide Science 2015      2016年   [査読有り]
Expression Analysis of Neuropeptide PDF mRNA in the Hypoactive and Hyperactive Fruit Flies Drosophila melanogaster.
Tokumaru, A., Matsuo, A., Umeno, S., Matsuyama, Y., Nakamura, M., Sumiyoshi, M., Liu, X., Matsushima, A., Shimohigashi, M., and Shimohigashi, Y.
Peptide Science 2015      2016年   [査読有り]
Do the Estrogen Receptors Function as a Homodimer? Experimental Validation of Homodimerization by Inhibitory Peptides.
Sakito, S., Liu, X., Fujiyama, A., Matsushima, A., and Shimohigashi. Y.
Peptide Science 2015      2016年   [査読有り]
Comprehensive structural analysis of the nociceptin ORL1 receptor by means of virtual and experimental Ala-scanning combinated methods.
Matsushima, A., Nishiimura, H., Liu, X., Takesue, Y., Matsuyama, Y., and Shimohigashi. Y.
Peptide Science 2015,      2016年   [査読有り]
Comparative Analysis of the Ligand Binding Domain Secondary Structures of Human Nuclear Receptors.
Matsuyama, Y., Nishimura H., Liu, X., Matsushima, A., and Shimohigashi. Y.
Peptide Science 2015      2016年   [査読有り]
The molecular switching of ORL1 nociceptin receptor in activation/inactivation.
Nishimura, H., Li, J., Isozaki, K., Takesue, Y., Liu, X., Shimohigashi, M., Inamine, S., Matsushima, A., and Shimohigashi. Y.:
Peptide Science 2014      2015年   [査読有り]
Structural and molecular evolutionary analysis of the ligand-binding domain of forty-eight human nuclear receptors
Matsuyama, Y., Nishimura H., Liu, X., Matsushima, A., and Shimohigashi. Y.
Peptide Science 2014      2015年   [査読有り]
GPCR functional role of Phe-269 and Phe-221 in the molecular switching of ORL1 nociceptin receptor activation.
Takesue, Y., Nishimura, H., Liu, X., Matsushima, A., and Shimohigashi. Y.
Peptide Science 2014      2015年   [査読有り]
Bisphenol A-induced substantial peak decay of Drosophila circadian neuropeptide hugin mRNA expression.
Umeno, S., Matsuo, A., Matsuyama, Y., Nakamura, M., Koga, K., Liu, X., Matsushima, A., Shimohigashi, M., and Shimohigashi, Y.
Peptide Science 2014      2015年   [査読有り]
An in silico genomic search of endomorphin-like opioid peptides
Matsushima, A., Koyanagi, O.K., Nishimura, H., Inamine, S., Motomatsu, Y., and Shimohigashi. Y.
Peptide Science 2014      2015年   [査読有り]
Alternative polyadenylation analyses of neuropeptide genes in bisphenol A-exposed hypoactive mouse brain.
Sugiyama, M., Kajiyama, S., Saito, T., Uchimura, E., Motomatsu, Y., Matsuo, A., Matsushima, A., and Shimohigashi. Y.
Peptide Science 2014      2015年   [査読有り]
A novel method to identify and Quantify the coactivator proteins that couple with human nuclear receptor: the use of interacting interface a-helix peptide for quantative inhibition
Liu, X., Matsushima, A., and Shimohigashi, Y.
Peptide Science 2014      2015年   [査読有り]
Structure-activity Studies on the Halogenated Phe-containing Neuropeptide Substance P Analogs.
Kuramitsu, Y., Nishimura, H., Nakamura, R., Suyama, K., Matsushima, A., Nose, T., and Shimohigashi, Y.
Peptide Science 2013      2014年   [査読有り]
Specific Role of Phe Residues in Opioid Peptide Met-enkephalin- Arg-Phe in Binding to All Three Opioid Receptors.
Motomatsu, Y., Nishimura, H., Matsumoto, Y., Inamine, S., Kuramitsu, Y., Matsushima, A., and Shimohigashi, Y.
Peptide Science 2013      2014年   [査読有り]
Multiple and Simultaneous Cys→Ala Mutations of ORL1 Nociceptin Receptor to Identify the Affinity Binding site of Cys(Npys)-Elongated RYYRIK Peptide Antagonist.
Matsushima, A., Nishimura, H., Inamine, S., and Shimohigashi, Y.
Peptide Science 2013      2014年   [査読有り]
Influence Analysis of the Circadian Evening Pacemaker Neuropeptide hugγ Gene in the Bisphenol A-exposed Fruit Fly Drosophila Brain.
Umeno, S., Matsuo, A. , Matsuyama, Y., Nakamura, M., Takeda, Y., Sumiyoshi, M., Liu, X., Matsushima, A., Shimohigashi, M., and Shimohigashi, Y.
Peptide Science 2013      2014年   [査読有り]
Functionally Essential Amino Acid Residues in ORL1 Nociceptin Receptor for Ligand-stimulated Receptor Activation.
Nishimura, H., Li, J., Isozaki, K., Abe, Y., Inamine, S., Matsushima, A., Costa, T., and Shimohigashi, Y.
Peptide Science 2013      2014年   [査読有り]
Expression and Mutation Analyses of Brain Neuropeptide Genes of Rndocrine-disrupting Bisphenol A-exposed Hypoactive Mouse.
Sugiyama, M., Matsuo, A., Saito, T., Uchimura, E., Liu, X., Matsushima, A., and Shimohigashi, Y.
Peptide Science 2013      2014年   [査読有り]
Constitutive α-Helix-peptides Required for Functional Dimerization of Estrogen-related Receptor γ (ERRγ).
Liu, X., Nishimura, H., Fujiyama, A., Matsushima, A., and Shimohigashi, Y.
Peptide Science 2013      2014年   [査読有り]
Bisphenol A-induced Epigenetic Mutations in Circadian Pacemaker Neuropeptide mRNAs of Hyperactive Drosophila Fruit Flies.
Matsuo, A., Umeno, S., Matsuyama, Y., Nakamura, M., Takeda, Y., Sumiyoshi, M., Liu, X., Matsushima, A., Shimohigashi, M., and Shimohigashi, Y.
Peptide Science 2013      2014年   [査読有り]
Three-dimensional Docking Modeling to Human Nuclear Receptors for Exploration of Bisphenol-A Targeting Receptors.
Matsuyama, Y., Liu, X., Nishimura, H., Matsushima, A., and Shimohigashi, Y.
Peptide Science 2013      2014年   [査読有り]
Two different binding modes of peptide library-based antagonist acyl-RYYRIK amide in the orl1 nociceptin receptor.
Inamine, S., Nishimura, H., Li, J., Matsushima, A. Costa, T., and Shimohigashi, Y.
Peptide Science 2012      2013年   [査読有り]
The impact of bisphenol A-feeding on the Drosophila neuropeptide PDF mRNA structure.
Matsuo, A., Nakamura, M., Takeda, Y., Matsuyama, Y., Sumiyoshi, M., Liu, X., Matsushima, A. Shimohigashi, M., and Shimohigashi, Y.
Peptide Science 2012      2013年   [査読有り]
Structural characteristics of Thr-Gly dipeptide repeat in the Drosophila clock protein PERIOD.
Matsuo, A., Nishimura, H., Nakamura, M., Koga, K., Sumiyoshi, M., Matsushima, A., Nose, T., Shimohigashi, M., and Shimohigashi, Y.
Peptide Science 2012      2013年   [査読有り]
Identification of affinity binding site of Cys(Npys)-elongated RYYRIK peptide antagonist by means of Cys→Ala mutated ORL1 nociceptin receptors.
Matsushima, A., Nishimura, H., Inamine, S., and Shimohigashi, Y.
Peptide Science 2012      2013年   [査読有り]
High-precision binding assay procedure of tachykinin receptor NK-1 for highly potent Substance P analogs.
Kuramitsu, Y., Nishimura, H., Nakamura, R., Suyama, K., Matsushima, A., Nose, T., and Shimohigashi, Y.
Peptide Science 2012      2013年   [査読有り]
Halogenated Phe-containing endomorphin-2 analogs with mixed agonist and antagonist activities.
Nishio, K., Nishimura, H., Suyama, K., Matsushima, A., Nose, T., and Shimohigashi, Y.
Peptide Science 2012      2013年   [査読有り]
Exploration of pharmacological chaperone for rescue of misfolded and/or unfolded ORL1 nociceptin receptor proteins.
Nishimura, H., Inamine, S., Li, J. Matsushima, A., and Shimohigashi, Y.
Peptide Science 2012      2013年   [査読有り]
Bisphenol-binding pocket of constitutively active nuclear receptor CAR: Docking modeling for close-packing.
Matsuyama, Y., Liu, X., Nishimura, H., Matsushima, A., Nose, T., and Shimohigashi, Y.
Peptide Science 2012      2013年   [査読有り]
The Trp residue of opioid receptor TM5 present at the cell membrane interface is a molecular anchor for full activation.
Nishimura, H., Li, J., Inokuchi, N., Koikawa, S., Matsushima, A., Nose, T., Costa, T. and Shimohigashi, Y.
Peptide Science 2010      2011年   [査読有り]
QCM-analyses of the intermolecular interaction between prion protein N-terminal Domains having increased number of octapeptide repeat
Sato, K., Horiuchi, Y., Matsushima, A., and Shimohigashi, Y.
Peptide Science 2011      2011年   [査読有り]
Exploration of the binding site of ORL1 nociceptin receptor antagonist.
Inamine, S., Li, J., Nishimura, H., Matsushima, A., Nose, T., Costa, T. and Shimohigashi, Y.
Peptide Science 2010      2011年   [査読有り]
The functional role of Trp present at the cell membrane interface in the opioid receptor activation.
Nishimura, H., Li, J., Inokuchi, N., Koikawa, A., Matsuhima, A., Nose, T., Costa, T., and Shimohigashi, Y.
Peptide Science 2009      2010年
The direct measure of intermolecular interaction of prion protein N-terminal octapeptide repeats by the quarts crystal microbalance (QCM).
Horiuchi, Y., Matsushima, A., and Shimohigashi, Y.
Peptide Science 2009      2010年
Shimohigashi, M., Itoh, T.Q., Honda, T., Saito, M., Koga, K., Takahashi, K., Matsushima, A., Ueda, R., Tanimura T., Shimohigashi, Y., and Matsumoto A.
Horiuchi, Y., Matsushima, A., and Shimohigashi, Y.
Peptide Science 2009      2010年
Structure-function analysis of nociceptin receptor ORL1 by the site-directed mutagenesis
Li, J., Isozaki, K., Matsushima, A., Nose, T., Costa, T., and Shimoohigashi, Y.
Peptide Science 2009      2010年
The preparation and purification of prion protein N-terminal domain with fluctuations in the number of octapeptide repeat
Sato, K., Horiuchi, Y., Matsushima, A., and shimohigashi, Y.
Peptide Science 2009      2010年
Functional role of the C-terminal Helix 12 peptide in the receptor activation mechanism of estrogen-related receptor γ (ERRγ).
Liu, X., Matsushima, A., Okada, H., and Shimohigashi, Y.
Peptide Science 2009      2010年
Induced-fit type ligand binding guided by free-rotatory Leu residue present in the 7th α-helix peptide in the estrogen-related receptor γ (ERRγ)
Matsushima, A., Okada, H., Liu, X., Tokunaga, T., Teramoto, T., Kakuta, Y., Shimohigashi, Y.
Peptide Science 2008      2009年
Molecular recognition of prion protein via its N-terminal octapeptide repeat Structure
Horiuchi, Y., Hattori, E., Yokotani, S., Matsushima, A., and Shimohigashi, Y.
Peptide Science 2008      2009年
ERα/ERRα Nuclear Receptor Heterodimer Directly Linked by A Flag Peptide.
Ikeda, S., Matsushim, A., and Shimohigashi, Y.
Peptide Science 2008      2009年
Bisphenol A-specific nuclear receptor ERRγ: structure-function analysis of the two novel isoforms lacking vital peptide fragment in the ligand binding domain
Takeda, Y., Liu, X., Sumiyoshi, M., Matsushima, A., Shimohigashi, Y. and Shimohigashi, M.
Peptide Science 2008      2009年
Optimization of the N-Terminal Group of Ac-RYYRIK-NH2 as ORL1 Receptor Antagonist
Li, J. Isozaki, K., Matsushima, A., Nose, T., Costa, T., and Shimohigashi, Y.
Peptide Science 2007      2008年
The Output Mechanism of Circadian Pacemaker Neuropeptide PDF in the Regulation of Bimodal Locomotor Distribution
Takeda, Y., Koga, K., Matsushima, A., Shimohigashi, M., and Shimohigashi, Y.
Peptide Science 2007      2008年
Structural Requirement of Housefly FMRFamide Peptides in Its Receptor Activation.
Matsushima, A., Koretsune, Y., Kaneki, A., Isozaki, K., Shimohigashi, M., and Shimohigashi, Y.
Peptide Science 2007      2008年
The Effect of Amino Acid Substitution on Oligomerization of Octapeptide Repeat Structure in Prion Protein.
Hattori, E., Yokotani, S., Horiuchi, Y., Matsushima, A., and Shimohigashi, Y.
Peptide Science 2007      2008年
A strategy to explore the target receptor of endocrine disruptors: Estrogen-related receptor γ (ERRγ) as a genuine acceptor of bisphenol A.
Matsushima, A., Shimohigashi, Y.
Alternatives to Animal Testing and Experimentation.AATEX journal, 14, special issue,      2008年
Immunological evidences of circadian neuropeptide PDF isoform present at the lamina outer cells and varicose network in the optic lobes of the cricket Gryllus bimaculatus
Honda, T., Matsushima, A., Hiramura, D., Sumida, K., Takeda, Y., Sato, S., Meinertzhagen I.A., Shimohigashi, Y., and Shimohigashi, M.,
Peptide Science 2005      2006年
Specific dimerization of prion protein N-terminal domain
Matsushima, A., Horiuchi, Y., Yokotani, S., Kawano, M., and Shimohigashi, Y.
Peptide Science 2005      2006年
Identification of novel isoforms of the circadian neuropeptide PDF in the silk moth Bombyx mori and their expression in brain
Sato, S., Jonathan C., Corrins, Takeda, Y., Kaneki, A., Matsushima, A., Shimohigashi, Y., and Shimohigashi, M.
Peptide Science 2005      2006年
a-helix peptides for bio-panning in the phage display method to obtain the antibodies specific for conformation-change nuclear receptors
Okada, H., Tokunaga, T., Shirasu N., Matsushima, A., Nose, T., and Shimohigashi Y.,
Peptide Science 2005      2006年
Design and synthesis of a-helix peptide binding to prion protein N-terminal octarepeat domain
Koga, K., Sato S., Horiuchi Y., Matsushima, A., and Shimohigashi, Y.
Peptide Science 2005      2006年
Conformation Change of α-Helix Peptide for Sensing of Deactivation of Nuclear Receptor: Immunoassay Using Polyclonal Antibody Specific for the C-terminal α-Helix 12 of Estrogen-related Receptor γ (ERRγ)
Tokunaga, T., Liu, X., Okada, H., Matsushima, A., Nose, T., Shimohigashi, M., and Shimohigashi, Y.
Peptide Science 2006      2006年
Molecular Cloning and in situ Hybridization of Circadian Neuropeptide PDF Receptor in the Fruit Fly Drosophila melanogaster
Kaneki, A., Yoshida, T., Isozaki, K., Matsushima A., Shimohigashi, M., and Shimohigashi, Y.
Peptide Science 2006      2006年
Immunological Confirmation of Circadian-related Neuropeptide PDF-Isoform Peptide in the Cricket Gryllus bimaculatus
Koga, K., Yakayama, Y., Hiramura, D., Takeda, Y., kaneki, A., Matsushima, A., Shimohigashi, Y., and Shimoshigashi, M.
Peptide Science 2006      2006年
Multiple Post-transcriptional Regulations in Circadian Pacemaker Neuropeptide pdf Gene
Takeda, Y., Sumiyuki, M., Koga, K., Ito, M., Matsushima, A., Shimohigashi, Y., and Shimohigashi, M.
Peptide Science 2006      2006年
Structure-Activity Studies of FMRFamide-Related Peptides in Activating the Specific Receptor Present in the Housefly Musca domestica
Matsushima, A. Koretsune, Y., Kaneki, A. Isozaki, K., Shimohigashi, M., and Shimohigashi, Y.
Peptide Science 2006      2006年
FMRFamide-Related Peptides in the Nervous System of the Housefly Musca domestica: cDNA Cloning and Actions on Clam Heart Contraction
Matsushima ., Yokotani, S., Koretsune, Y., Meinertzhagen, I.A., Tominaga, Y., Shimohigashi, M., and Shimohigashi, Y.
Peptide Science 2004      2005年
Structural Characteristics of the N-Terminal Octapeptide Repeat Region of Prion Protein in Self-Polymerization
Horiuchi, Y., Kawano, M., Yokotani, S., Honda, T., Matsushima, A., Nose, T., and Shimohigashi, Y.
Peptide Science 2004      2005年
Bioactive Conformation of a D-Trp-Containing Cardioexcitatory Tripeptide Isolated from the Sea Hare Aplysia
okotani, S., Matsushima, A., Nose, T., Morishita, F., and Shimohigashi Y.
Peptide Science 2004      2005年
cDNA Cloning and mRNA Expression of the Circadian Neuropeptide PDF in the Silk Moth Bombyx mori
Sato, S., Sumida, K., Hiramura, D., Matsushima, A., Tominaga, Y., Shimohigashi, Y., and Shimohigashi, M.
Peptide Science 2004      2005年
Structural Characteristics of Drosophila Estrogen-Related Receptor Ligand Binding Domain to Capture the Peptide and Non-peptide Ligands
Liu, X., Matsushima, A., Shirasu, N., Tominaga, Y., Shimohigashi, M., Shimohigashi, Y., and Nose, T.
Peptide Science 2004      2005年
Triplicate Alternative Splicings that Produce Multiple Variants of the PERIOD Protein in the Silk Moth Bombyx mori by Deletion/Insertion of Peptides
Takeda, Y., Shirasu, N., Sato, S., Matsushima, A., Chuman, Y., Tominaga, Y., Shimohigashi, M., and Shimohigashi, M.
Peptide Science 2004      2005年
Conformation Change-senseing Assay Using Monoclonal Antibody for N-terminal Octapeptide Repreat Region of Prion Protein
Kawano, M., Honda, T., Horiuchi, Y., Yokotani, S., Matsushima, A., Nose, T., and Shimohigashi, Y.
Peptide Science 2004      2005年
Immunocytochemical Identification of Mature Peptide Formation for the Circadian Neuromodulator PDF in the Housefly Musca domestica
Sumida, K., Honda, T., Matsushima, A., Tominaga, Y., Shimohigashi, Y., and Shimohigashi, M.
Peptide Science 2004      2005年
Immunocytochemical Studies on the Circadian Neuropeptide PDF in the Cricket Gryllus bimaculatus
Shimohigasi M., Honda T., Matsushima A., Sumida K., Meinertzhagen, I.A., Shimohigasi Y., and Tominaga Y.
Peptide Science 2004      2005年
cDNA Cloning and in situ hybridization studies of sulfated peptide, sulfakinin, on housefly Musca domestica
A. Matsushima, S. Yokotani, Y. Shimohigashi, Y. Tominaga, M. Shimohibashi
Peptide Science 2003      2004年
Localization Profiles of circadian Neuropeptide PDF in Brain of the Cricket Gryllus bimaculatus
T. Honda, Y. Chuman, A. Matsushima, Y. Nose, K. Sakaguti, H. Onoue, Y. Tominaga, Y. Shimohigashi, and M. Shimohigashi
Peptide Science 2003      2004年
Two Distinctly Different Isoforms with/without Pentapeptide Fragment in the Silk Moth Clock protein peptide
Y. Takeda, N. Shirasu, S. Sato, A. Matsushima, Y. Chuman, M. Shimohigashi, and Y. Shimohigashi
Peptide Science 2003      2004年
Effect of the Phe-Phenyl H→F subsutitution in the Sea Hare Aplysia Neuropeptide H-Asn-d-Phe-NH2 on the Conformation and Contraction Activity
S. Yokotani, A. Matsushima, T. Nose, Y. Shimohigashi, F. Morishita
Peptide Science 2003      2004年
A. Kaneki, A. Matsushima, Y. Takeda, S. Yokotani, M. Ozaki, M. Shimohigashi, and Y. Shimohigashi
31. M. Kawano, Y. Horiuchi, T Honda, S. Yokotani, A. Matushima, T, Nose, and Y. Shimohigashi
Peptide Science 2003      2004年
Structural Requirements of the N-terminal Octapeptide Repeat of Prion Protein
31. M. Kawano, Y. Horiuchi, T Honda, S. Yokotani, A. Matushima, T, Nose, and Y. Shimohigashi
Peptide Science 2003      2004年
Structural characterization of the house fly PDF, a circadian rhythm pacemaker hormone
A. Matsushima, T. Nose, Y. Tomioka, M. Shimohigashi, Y. Shimohigashi
Peptide Science 2002      2003年
Localization Profiles of the Precursor Protein of Circadian Rhythm Pacemaker Hormone PDF in Gryllus Brain
T. Honda, Y. Chuman, A. Matsushima, D. Asai, T. Nose, K. Sakaguchi, H. Onoue, Y. Tominaga, Y. Shimohigashi, and M. Shimohigashi
Peptide Science 2002      2003年
The Structure-activity Studies of Drosophila FMRFamide-related Peptides
T. Tokunaga, M. Ohtani, A. Matsushima, T. Nose, M. Shimohigashi, S. Aimoto, and Y. Shimohigashi
Peptide Science 2002      2003年
Structural Analysis of PERIOD-PAS Domain Binding Regions in Insect Clock Protein TIMELESS
S. Sato, H. Oka, A. Matsushima, Y. Tominaga, Y. Shimohigashi, and M. Shimohigashi
Peptide Science 2002      2003年
Structure and Function of Nuclear Localization Signal Peptide Present in Circadian Rhythm Hormone Peptide Precursor
Matsushima, A., Chuman, Y., Sato, S., Tominaga, Y., Shimohigashi, Y., and Shimohigashi M.
Comp. Biochem. Physiol.      2002年
cDNA Cloning of PDF Peptide Precursors in Housefly and Last Summer Cicada
Sato, S., Matsushima, A., Chuman, Y., Tominaga, K., Shimohigashi, Y., and Shimohigashi, M.
Peptide Science 2001      2002年
Contractile Activity of Drosophila FMRFamide-Related Peptides in the Meretrix Lusoria Heart Muscle
Tokunaga, T., Ohtani, M., Matsushima, A., Chuman, Y., Nose, T., Shimohigashi, Y., Aimoto, S., and Shimohigashi, Y.
Peptide Science 2001      2002年
Design and Preparation of Universal Anti-PERIOD Antibodies and their Immunoresponses
Asai, D., Tokunaga, T., Matsushima, A., Sato, S., Chuman, Y., Nose, T., Tominaga, Y., Shimohigashi, Y., and Shiimohigashi, M.
Peptide Science 2001      2002年
cDNA cloning of a Circadian Rhythm Pacemaker Hormone PDF of theHouse Fly Musca domestica
Matsushima, A., Cuman, Y., Sato, S., Shimohigashi, Y., Tominaga, Y., and Shimohigashi, M.
Comp. Biochem. Physiol.      2001年
PERIOD Clock Protein of the Summer Cicada Meimuna opalifera: cDNA Cloning and Structural Analysis
Sato, S., Chuman, Y., Matsushima, A., Shimohigashi, Y., Tominaga, Y., and Shimohigashi, M.
Comp. Biochem. Physiol.      2001年
Circadian Rhythm Pacemaker Neuropeptide 'PDF' in Nocturnal Insect Cricket Gryllus bimaculatus: cDNA Cloning, mRNA Expression, and Nuclear Localization
Chuman, Y., Matsushima, A., Shimohigashi, Y., and Shimohigashi M.
American Peptide Society 2001      2001年
Gene Expression of a Circadian Pacemaker Hormone Peptide PDF in Cricket Gryllus bimaculatus,
Matsushima, A., Chuman, Y., Onoue, H., Ito, Y., Tomioka, K., Tominaga, Y., Shimohigashi, Y., and Shimohigashi M.
Peptide Science 2000      2001年
cDNA Cloning of Circadian Rhythm Pacemaker Neuropeptide PDF in Gryllus bimaculatus and Its Neuclear Localization
Chuman, A., Matsushima, T., Nose, Y., Shimohigashi, and M., Shimohigashi
Peptide Science 2000      2001年
Activity Enhancement by Introduction of Two Different Halogen Atoms into Phe-2-phenyl Group of Thrombin Receptor Tetherd-Ligand Analogs
Fujita, T., Inoue, N., Matsuhima, A., Nose, T., Costa, T., and Shimohigashi, Y.
Peptide Science 2000      2001年
Edge-to-face CH/π Interaction between Ligand Phe-phenyl and Receptor Aromatic Group in Thrombin Receptor Activation
Matsushima, A., Fujita, T., Okada, K., Nose, T., and Shimohigashi, Y.
J. Biochem.      2000年
Highly Potent Peptide Ligands for Thrombin Receptor
Fujita, T., Nose, T., Matsushima, A., Costa, T., and Shimohigashi, Y.
Peptide Science 1999      2000年
Chemical Syntheses of Phenylalanine Derivatives Containing Halogenated Benzene Ring as Structural Explorers for Elucidation of Molecular Mechanisms of Receptor Interactions
Matsushima, A., Fujita, T., Okada, K., Yamauchi, Y., Nose, T., and Shimohigashi, Y.
Peptide Science 1999      2000年
Importance of Ligand Phe-phenyl Group for Activation of Thrombin Receptor
Fujita,T., Nose, T., Matsushima, A., Costa, T., and Shimohigashi, Y.
Peptide Science 1998      1999年

講演・口頭発表等

 
西元敦也, 十時崇彰, LIU Xiaohui, 松島綾美
日本内分泌かく乱化学物質学会研究発表会要旨集   2017年12月   
袈裟丸仁志, 金子周平, 大久保貴史, 笠谷和見, 巣山慶太郎, 枡屋宇洋, LIU Xiaohui, 松島綾美, 野瀬健, 野瀬健, 野瀬健
日本内分泌かく乱化学物質学会研究発表会要旨集   2017年12月   
枡屋宇洋, 倉八大樹, LIU Xiaohui, 松島綾美
化学関連支部合同九州大会・外国人研究者交流国際シンポジウム講演予稿集   2017年7月1日   
大久保貴史, 金子周平, LIU Xiaohui, 松島綾美, 袈裟丸仁志, 巣山慶太郎, 野瀬健
化学関連支部合同九州大会・外国人研究者交流国際シンポジウム講演予稿集   2017年7月1日   

所属学協会

 
日本生化学会 , 日本化学会 , 日本ペプチド学会 , 日本比較生理生化学会 , 環境ホルモン学会 [正式名称;日本内分泌撹乱化学物質学会] , DV-Xα研究協会

競争的資金等の研究課題

 
概日リズムの新規ペースメーカーホルモンの同定と構造機能解析
科学研究費補助金
研究期間: 2001年   
プリオンタンパク質のコンホメーション変化誘導の構造要因と誘導要因センシング
科学研究費補助金
研究期間: 2004年   

特許

 
下東 康幸, 松島 綾美, 鍵本 忠尚, 和田 淳, 東 芳, 米田 茂之