八木下　尚子

研究者氏名	八木下　尚子
	ヤギシタ　ナオコ
eメール	yagimarianna-u.ac.jp
URL	http://nanchiken.jp/
所属	聖マリアンナ医科大学
部署	難病治療研究センター
職名	講師
学位	修士(東京大学)
科研費研究者番号	40367389

研究キーワード

ノックアウトマウス , 疾患モデル動物 , 関節リウマチ

研究分野

実験動物学 / 実験動物学 /
生物科学 / 分子生物学 /
内科系臨床医学 / 膠原病・アレルギー内科学 /

経歴

1999年4月

ニプロ株式会社医薬品研究開発部医薬品研究所

2002年3月

株式会社ロコモジェン研究員

2002年10月

株式会社ロコモジェン主任研究員

2003年4月

聖マリアンナ医科大学難病治療研究センター助手

2005年4月

聖マリアンナ医科大学難病治療研究センター講師

学歴

1999年

東京大学農学生命科学研究科応用生命工学

1997年

東京農業大学農学部農芸化学科

論文

Mogamulizumab (Anti-CCR4) in HTLV-1-Associated Myelopathy.

Sato T, Coler-Reilly ALG, Yagishita N, Araya N, Inoue E, Furuta R, Watanabe T, Uchimaru K, Matsuoka M, Matsumoto N, Hasegawa Y, Yamano Y

The New England journal of medicine 378(6) 529-538 2018年2月 [査読有り]

Inhibitory effects of ubiquitination of synoviolin by PADI4.

Aratani S, Fujita H, Yagishita N, Yamano Y, Okubo Y, Nishioka K, Nakajima T

Molecular medicine reports 16(6) 9203-9209 2017年12月 [査読有り]

Effectiveness of Daily Prednisolone to Slow Progression of Human T-Lymphotropic Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis: A Multicenter Retrospective Cohort Study.

Coler-Reilly ALG, Sato T, Matsuzaki T, Nakagawa M, Niino M, Nagai M, Nakamura T, Takenouchi N, Araya N, Yagishita N, Inoue E, Yamano Y

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 14(4) 1084-1094 2017年10月 [査読有り]

Nation-wide epidemiological study of Japanese patients with rare viral myelopathy using novel registration system (HAM-net).

Coler-Reilly AL, Yagishita N, Suzuki H, Sato T, Araya N, Inoue E, Takata A, Yamano Y

Orphanet journal of rare diseases 11(1) 69 2016年5月 [査読有り]

The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1β.

Fujita H, Yagishita N, Aratani S, Saito-Fujita T, Morota S, Yamano Y, Hansson MJ, Inazu M, Kokuba H, Sudo K, Sato E, Kawahara K, Nakajima F, Hasegawa D, Higuchi I, Sato T, Araya N, Usui C, Nishioka K, Nakatani Y, Maruyama I, Usui M, Hara N, Uchino H, Elmer E, Nishioka K, Nakajima T

The EMBO journal 34 1042-1055 2015年4月 [査読有り]

Synoviolin inhibitor LS-102 reduces endoplasmic reticulum stress-induced collagen secretion in an in vitro model of stress-related interstitial pneumonia.

Nakajima F, Aratani S, Fujita H, Yagishita N, Ichinose S, Makita K, Setoguchi Y, Nakajima T

International journal of molecular medicine 35 110-116 2015年1月 [査読有り]

Mogamulizumab, an anti-CCR4 antibody, targets human T-lymphotropic virus type 1-infected CD8+ and CD4+ T cells to treat associated myelopathy.

Yamauchi J, Coler-Reilly A, Sato T, Araya N, Yagishita N, Ando H, Kunitomo Y, Takahashi K, Tanaka Y, Shibagaki Y, Nishioka K, Nakajima T, Hasegawa Y, Utsunomiya A, Kimura K, Yamano Y

The Journal of infectious diseases 211 238-248 2015年1月 [査読有り]

HTLV-1 induces a Th1-like state in CD4+CCR4+ T cells.

Araya N, Sato T, Ando H, Tomaru U, Yoshida M, Coler-Reilly A, Yagishita N, Yamauchi J, Hasegawa A, Kannagi M, Hasegawa Y, Takahashi K, Kunitomo Y, Tanaka Y, Nakajima T, Nishioka K, Utsunomiya A, Jacobson S, Yamano Y

The Journal of clinical investigation 124 3431-3442 2014年8月 [査読有り]

Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis.

Wu T, Zhao F, Gao B, Tan C, Yagishita N, Nakajima T, Wong PK, Chapman E, Fang D, Zhang DD

Genes & development 28 708-722 2014年4月 [査読有り]

Vulnerability to traumatic stress in fibromyalgia patients: 19 month follow-up after the great East Japan disaster.

Usui C, Hatta K, Aratani S, Yagishita N, Nishioka K, Okamura S, Itoh K, Yamano Y, Nakamura H, Asukai N, Nakajima T, Nishioka K

Arthritis research & therapy 15 R130 2013年9月 [査読有り]

Positive feedback loop via astrocytes causes chronic inflammation in virus-associated myelopathy.

Ando H, Sato T, Tomaru U, Yoshida M, Utsunomiya A, Yamauchi J, Araya N, Yagishita N, Coler-Reilly A, Shimizu Y, Yudoh K, Hasegawa Y, Nishioka K, Nakajima T, Jacobson S, Yamano Y

Brain : a journal of neurology 136 2876-2887 2013年9月 [査読有り]

The Japanese version of the modified ACR preliminary diagnostic criteria for fibromyalgia and the fibromyalgia symptom scale: reliability and validity.

Usui C, Hatta K, Aratani S, Yagishita N, Nishioka K, Kanazawa T, Itoh K, Yamano Y, Nakamura H, Nakajima T, Nishioka K

Modern rheumatology / the Japan Rheumatism Association 23 846-850 2013年9月 [査読有り]

CSF CXCL10, CXCL9, and neopterin as candidate prognostic biomarkers for HTLV-1-associated myelopathy/tropical spastic paraparesis.

Sato T, Coler-Reilly A, Utsunomiya A, Araya N, Yagishita N, Ando H, Yamauchi J, Inoue E, Ueno T, Hasegawa Y, Nishioka K, Nakajima T, Jacobson S, Izumo S, Yamano Y

PLoS neglected tropical diseases 7 e2479 2013年 [査読有り]

RING-finger type E3 ubiquitin ligase inhibitors as novel candidates for the treatment of rheumatoid arthritis.

Yagishita N, Aratani S, Leach C, Amano T, Yamano Y, Nakatani K, Nishioka K, Nakajima T

International journal of molecular medicine 30 1281-1286 2012年12月 [査読有り]

[The current and future approaches to the treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)].

Yamano Y, Sato T, Ando H, Araya N, Yagishita N

Nihon rinsho. Japanese journal of clinical medicine 70 705-713 2012年4月 [査読有り]

The Japanese version of the 2010 American College of Rheumatology Preliminary Diagnostic Criteria for Fibromyalgia and the Fibromyalgia Symptom Scale: reliability and validity.

Usui C, Hatta K, Aratani S, Yagishita N, Nishioka K, Kanazawa T, Ito K, Yamano Y, Nakamura H, Nakajima T, Nishioka K

Modern rheumatology / the Japan Rheumatism Association 22 40-44 2012年2月 [査読有り]

Overexpression of SPACIA1/SAAL1, a newly identified gene that is involved in synoviocyte proliferation, accelerates the progression of synovitis in mice and humans.

Sato T, Fujii R, Konomi K, Yagishita N, Aratani S, Araya N, Aono H, Yudoh K, Suzuki N, Beppu M, Yamano Y, Nishioka K, Nakajima T

Arthritis and rheumatism 63 3833-3842 2011年12月 [査読有り]

Human T-lymphotropic virus type 1 (HTLV-1) and regulatory T cells in HTLV-1-associated neuroinflammatory disease.

Araya N, Sato T, Yagishita N, Ando H, Utsunomiya A, Jacobson S, Yamano Y

Viruses 3 1532-1548 2011年9月 [査読有り]

Prostaglandin EP2 receptor signalling inhibits the expression of matrix metalloproteinase 13 in human osteoarthritic chondrocytes.

Sato T, Konomi K, Fujii R, Aono H, Aratani S, Yagishita N, Araya N, Yudoh K, Beppu M, Yamano Y, Nishioka K, Nakajima T

Annals of the rheumatic diseases 70 221-226 2011年1月 [査読有り]

Fucoidan therapy decreases the proviral load in patients with human T-lymphotropic virus type-1-associated neurological disease.

Araya N, Takahashi K, Sato T, Nakamura T, Sawa C, Hasegawa D, Ando H, Aratani S, Yagishita N, Fujii R, Oka H, Nishioka K, Nakajima T, Mori N, Yamano Y

Antiviral therapy 16 89-98 2011年 [査読有り]

E3 ubiquitin ligase synoviolin is involved in liver fibrogenesis.

Hasegawa D, Fujii R, Yagishita N, Matsumoto N, Aratani S, Izumi T, Azakami K, Nakazawa M, Fujita H, Sato T, Araya N, Koike J, Tadokoro M, Suzuki N, Nagata K, Senoo H, Friedman SL, Nishioka K, Yamano Y, Itoh F, Nakajima T

PloS one 5 e13590 2010年10月 [査読有り]

Role of Kenae/CCDC125 in cell motility through the deregulation of RhoGTPase.

Araya N, Arimura H, Kawahara K, Yagishita N, Ishida J, Fujii R, Aratani S, Fujita H, Sato T, Yamano Y, Higuchi I, Osame M, Nishioka K, Fukamizu A, Arimura K, Maruyama I, Nakajima T

International journal of molecular medicine 24 605-611 2009年11月 [査読有り]

An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid beta-protein.

Maeda T, Marutani T, Zou K, Araki W, Tanabe C, Yagishita N, Yamano Y, Amano T, Michikawa M, Nakajima T, Komano H

The FEBS journal 276 5832-5840 2009年10月 [査読有り]

Severe loss of invariant NKT cells exhibiting anti-HTLV-1 activity in patients with HTLV-1-associated disorders.

Azakami K, Sato T, Araya N, Utsunomiya A, Kubota R, Suzuki K, Hasegawa D, Izumi T, Fujita H, Aratani S, Fujii R, Yagishita N, Kamijuku H, Kanekura T, Seino K, Nishioka K, Nakajima T, Yamano Y

Blood 114 3208-3215 2009年10月 [査読有り]

Abnormally high levels of virus-infected IFN-gamma+ CCR4+ CD4+ CD25+ T cells in a retrovirus-associated neuroinflammatory disorder.

Yamano Y, Araya N, Sato T, Utsunomiya A, Azakami K, Hasegawa D, Izumi T, Fujita H, Aratani S, Yagishita N, Fujii R, Nishioka K, Jacobson S, Nakajima T

PloS one 4 e6517 2009年8月 [査読有り]

Activation of synoviolin promoter in rheumatoid synovial cells by a novel transcription complex of interleukin enhancer binding factor 3 and GA binding protein alpha.

Izumi T, Fujii R, Izumi T, Nakazawa M, Yagishita N, Tsuchimochi K, Yamano Y, Sato T, Fujita H, Aratani S, Araya N, Azakami K, Hasegawa D, Kasaoka S, Tsuruta R, Yokouti M, Ijiri K, Beppu M, Maruyama I, Nishioka K, Maekawa T, Komiya S, Nakajima T

Arthritis and rheumatism 60 63-72 2009年1月 [査読有り]

Increased prevalence of group A β-hemolytic streptococcus among an ethnic population in Kyrgyzstan detected by the rapid antigen detection test.

Omurzakova NA, Yamano Y, Sato T, Izumi T, Azakami K, Hasegawa D, Fujii R, Yagishita N, Aratani S, Kabaeva ZS, Mirrakhimov MM, Kami M, Maruyama I, Osame M, Yokota S, Nishioka K, Nakajima T

Molecular medicine reports 1 869-874 2008年11月 [査読有り]

Synoviolin, protein folding and the maintenance of joint homeostasis.

Yagishita N, Yamasaki S, Nishioka K, Nakajima T

Nature clinical practice. Rheumatology 4 91-97 2008年2月 [査読有り]

The roles of synoviolin in crosstalk between endoplasmic reticulum stress-induced apoptosis and p53 pathway.

Yamasaki S, Yagishita N, Nishioka K, Nakajima T

Cell cycle (Georgetown, Tex.) 6 1319-1323 2007年6月 [査読有り]

Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'.

Yamasaki S, Yagishita N, Sasaki T, Nakazawa M, Kato Y, Yamadera T, Bae E, Toriyama S, Ikeda R, Zhang L, Fujitani K, Yoo E, Tsuchimochi K, Ohta T, Araya N, Fujita H, Aratani S, Eguchi K, Komiya S, Maruyama I, Higashi N, Sato M, Senoo H, Ochi T, Yokoyama S, Amano T, Kim J, Gay S, Fukamizu A, Nishioka K, Tanaka K, Nakajima T

The EMBO journal 26 113-122 2007年1月 [査読有り]

[Synoviolin as a causative factor of arthropathy].

Yagishita N, Nakajima T

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 51 1298-1303 2006年8月 [査読有り]

Resistance to endoplasmic reticulum stress is an acquired cellular characteristic of rheumatoid synovial cells.

Yamasaki S, Yagishita N, Tsuchimochi K, Kato Y, Sasaki T, Amano T, Beppu M, Aoki H, Nakamura H, Nishioka K, Nakajima T

International journal of molecular medicine 18 113-117 2006年7月 [査読有り]

Comparative analysis of gene expression profiles in intact and damaged regions of human osteoarthritic cartilage.

Sato T, Konomi K, Yamasaki S, Aratani S, Tsuchimochi K, Yokouchi M, Masuko-Hongo K, Yagishita N, Nakamura H, Komiya S, Beppu M, Aoki H, Nishioka K, Nakajima T

Arthritis and rheumatism 54 808-817 2006年3月 [査読有り]

Identification of a crucial site for synoviolin expression.

Tsuchimochi K, Yagishita N, Yamasaki S, Amano T, Kato Y, Kawahara K, Aratani S, Fujita H, Ji F, Sugiura A, Izumi T, Sugamiya A, Maruyama I, Fukamizu A, Komiya S, Nishioka K, Nakajima T

Molecular and cellular biology 25 7344-7356 2005年8月 [査読有り]

[Mechanism for synovial hyperplasia in rheumatoid arthritis].

Kato Y, Yamasaki S, Yagishita N, Tsuchimochi K, Nakajima T

Nihon rinsho. Japanese journal of clinical medicine 63 Suppl 5 199-204 2005年5月 [査読有り]

Essential role of synoviolin in embryogenesis.

Yagishita N, Ohneda K, Amano T, Yamasaki S, Sugiura A, Tsuchimochi K, Shin H, Kawahara K, Ohneda O, Ohta T, Tanaka S, Yamamoto M, Maruyama I, Nishioka K, Fukamizu A, Nakajima T

The Journal of biological chemistry 280 7909-7916 2005年3月 [査読有り]

Rheumatoid arthritis as a hyper-endoplasmic-reticulum-associated degradation disease.

Yamasaki S, Yagishita N, Tsuchimochi K, Nishioka K, Nakajima T

Arthritis research & therapy 7 181-186 2005年 [査読有り]

Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy.

Amano T, Yamasaki S, Yagishita N, Tsuchimochi K, Shin H, Kawahara K, Aratani S, Fujita H, Zhang L, Ikeda R, Fujii R, Miura N, Komiya S, Nishioka K, Maruyama I, Fukamizu A, Nakajima T

Genes & development 17 2436-2449 2003年10月 [査読有り]