日本の女性研究者

生物学

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FUJII Noriko

 
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NameFUJII Noriko
e-mailnfujiirri.kyoto-u.ac.jp
AffiliationKyoto University
SectionResearch Reactor Institute, Research Reactor Institute Division of Radiation Life Science
Job titleProfessor,Professor
DegreeDoctor of Medicine
Research funding number90199290

Research Interests

 
crystallin , racemization , Abnormal aggregation of protein , cataract , aging , D-amino acid , Biochemistry

Research Areas

 
  • Biological science / Functional biochemistry / 

Education

 
 
 - 
1980
Graduate School, Division of Medicine, Tokyo Medical and Dental University
 
 
 - 
1974
Faculty of Agriculture, Meiji University
 

Published Papers

 
Identification of Isomeric Aspartate residues in βB2-crystallin from Aged Human Lens.
Takata T, Murakami K, Toyama A, Fujii N.
Biochim Biophys Acta-Proteins and Proteomics.   1866 767-774   2018   [Refereed]
D-Amino acids in protein: The mirror of life as a molecular index of aging.
Fujii N, Takata T, Fujii N, Aki K and Sakaue H.
BBA - Proteins and Proteomics   1866 840-847   2018   [Refereed]
Asp58 modulates lens αA-crystallin oligomer formation and chaperone function.
Takata T, Nakamura-Hirota T, Inoue R, Morishima K, Sato N, Sugiyama M and Fujii N. 
FEBS Journal   285 2263-2277   2018   [Refereed]
Identification of ᴅ-amino acid-containing peptides in human serum.
FUJII Noriko
PLoS ONE   12(12) e0189972   2017   [Refereed]
FUJII Noriko
Glycative Stress Research   4 203-211   2017   [Refereed]
Ferulic Acid Suppresses Amyloid β Production in the Human Lens Epithelial Cell Stimulated with Hydrogen Peroxide.
Nagai N, Kotani S, Mano Y, Ueno A, Ito Y, Kitaba T, Takata T and Fujii N.
BioMed. Res. Int.   2017 5343010   2017   [Refereed]
Isomeric replacement of a single aspartic acid induces a marked change in protein function: The Example of Ribonuclease A.
FUJII Noriko
ACS Omega   2 260-267   2017   [Refereed]
Kim I, Saito T, Fujii N, Kanamoto T and Fujii N.
Amino Acids   48 2855-2866   2016   [Refereed]
Inoue R, Takata T, Fujii N, Ishii K, Uchiyama S, Sato N, Oba Y, Wood K, Kato K, Fujii N & Sugiyama M.
Scientific Reports   6 29208   2016   [Refereed]
FUJII N, Takata T, Fujii N and Aki K.
Biochimica et Biophysica Acta -General Subjects   1860 183-191   2016   [Refereed]
Takata T and Fujii N.
J. Pharm. Biomed Anal.   116 139-144   Jun 2015   [Refereed]
Ramkumar S, Fujii N, Sakaue H, Fujii N, Thankappan B, Kumari RP, Natarajaseenivasan K, Anbarasu K.
Amino Acids.   47 1035-1043   May 2015   [Refereed]
Ramkumar S, Thankappan B, Fujii N, Natarajaseenivasan K, Anbarasu K.
Int. J. Biol. Macromol.   76 102-108   May 2015   [Refereed]
Maeda H, Takata T, Fujii N, Sakaue H, Nirasawa S, Takahashi S, Sasaki H and Fujii N
Anal. Chem   87 561-568   Jan 2015   [Refereed]
Kim I, Saito T, Fujii N, Kanamoto T, Chatake T, Fujii N.
Biochem.Biophys.Res.Commu   466 622-628   2015   [Refereed]
Cataract Formation and Age-Dependent Post-Translational Modifications in Crystallin, The Journal of the Japanese Society for Cataract Research
Fujii N, Takata, T.
The Journal of the Japanese Society for Cataract Research   27 15-18   2015   [Refereed]
Fujii N, Takata, T. and Fujii N.
J. Pharm. Biomed. Anal.   116 25-33   2015   [Refereed]
Sakaue H, Takata T, Fujii N, Sasaki, H and Fujii N.
Biochimica et Biophysica Acta -Proteins and Proteomics   1854 1-9   Nov 2014   [Refereed]
Ono K Fujimoto E, Fujimoto N, Akiyama M, Satoh T, Maeda H, Fujii N, Tajima S 
J Biol Chem.   289 29195-29207   Aug 2014   [Refereed]
Uehara M, Matsuda K, Kato A, Sato S , Shimizu F, Ooatari1 M, Kai Y, Shimada H, Hatano Y, Okamoto O, Katagiri K, Sasaki T, Fujii N, Fujiwara S.
Eur J Dermatol   24 691-693   Jul 2014   [Refereed]
T. Saito; N. Fujii
Radiation Physics and Chemistry   98 57-63   2014   [Refereed]
Comparison of effect of gamma ray irradiation on wild-type and N-terminal mutants of αA-crystallin.
Ramkumar S, Fujii N, Fujii N, Thankappan B, Sakaue H, Ingu K, Natarajaseenivasan K, Anbarasu K.
Molecular Vision   20 1002-1016   2014   [Refereed]
D-amino acid as a biomarker for the photo-aging mechanism.
Fujii N,
Journal of clinical and experimental medicine   248 602-607   2014   [Refereed]
New Analysis of Aspartyl Isomers in Cataractous Lens Proteins
Fujii N and Fujii N.
The Journal of the Japanese Society for Cataract Research   26 33-36   2014   [Refereed]
Y. Miura; S. Harumiya; K. Ono; E. Fujimoto; M. Akiyama; N. Fujii; H. Kawano; H. Wachi; S. Tajima
Experimental Dermatology   22(1) 36-40   Jan 2013   [Refereed]
B. Thankappan; S. Jeyarajan; S. Hiroaki; K. Anbarasu; K. Natarajaseenivasan; N. Fujii
Applied Biochemistry and Biotechnology   170(5) 1184-1193   2013   [Refereed]
S. Cai; T. Saito; N. Fujii
Free Radical Biology and Medicine   65 1037-1046   2013   [Refereed]
N. Numoto; A. Kita; N. Fujii; K. Miki
Biochemical and Biophysical Research Communications   425(3) 601-606   Aug 2012   [Refereed]
Y. Kaji; T. Oshika; Y. Takazawa; M. Fukayama; N. Fujii
British Journal of Ophthalmology   96(8) 1127-1131   Aug 2012   [Refereed]
Structural features of isomerizable aspartyl residues in human α-crystallins
K.-I. Shimizu; A. Kita; N. Fujii; K. Miki
Molecular Vision   18 1823-1827   Jul 2012   [Refereed]
Effects of D-aspartyl residues in structural and functional properties of human lens α-crystallin.
N. Fujii
The Journal of the Japanese Society for Cataract Research   24(1) 5-9   Jun 2012   [Refereed]
FUJII Noriko;FUJII Norihiko;SUGIYAMA Masaaki
Trans Mater Res Soc Jpn   37(2) 131-134   Jun 2012   [Refereed]
Characterization of an antibody that recognizes peptides containing D-β-aspartyl residues
K. Aki; N. Fujii; T. Saito; N. Fujii
Molecular Vision   18 996-1003   Apr 2012   [Refereed]
N. Fujii; N. Fujii
Methods in Molecular Biology   794 325-335   2012   [Refereed]
H. Tamura; N. Ohgami; I. Yajima; M. Iida; K. Ohgami; N. Fujii; H. Itabe; T. Kusudo; H. Yamashita; M. Kato
PLoS ONE   7(6)    2012   [Refereed]
N. Fujii; H. Sakaue; H. Sasaki; N. Fujii
The Journal of biological chemistry   287(47) 39992-40002   2012   [Refereed]
A rapid comprehensive LC-MS based survey of the Asp isomers in crystallins from human cataract lenses.
Norihiko Fujii , Hiroakai Sakaue, Hiroshi Sasaki and Noriko Fujii.
J Biol. Chem.   287 39992-40002   2012   [Refereed]
The study of chemical modification of lens protein for the cataract prevention.
Fujii N and Fujii N.
IOL &RS   26 290-294   2012
The presence and role of D-amino acids in the living organisms. Amino acid Research
N. Fujii
Amino Acid Research   6 19-24   2012
N. Fujii; N. Fujii; T. Kawaguchi; H. Sasaki
Biochemistry   50(40) 8628-8635   Nov 2011   [Refereed]
N. Fujii; Y. Kaji; N. Fujii
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences   879(29) 3141-3147   Nov 2011   [Refereed]
Y. Sadakane; N. Fujii; K. Nakagomi
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences   879(29) 3240-3246   Nov 2011   [Refereed]
Y. Mori; K. Aki; K. Kuge; S. Tajima; N. Yamanaka; Y. Kaji; N. Yamamoto; R. Nagai; H. Yoshii; N. Fujii; M. Watanabe; T. Kinouchi; N. Fujii
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences   879(29) 3303-3309   Nov 2011   [Refereed]
T. Kinouchi; N. Fujii; N. Fujii
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences   879(29) 3349-3352   Nov 2011   [Refereed]
A. Shimada; H. Ozaki; T. Saito; N. Fujii
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences   879(29) 3289-3295   2011   [Refereed]
Clarification of cataract mechanisms-Approach from protein chemistry
N. Fujii
The Journal of the Japanese Society for Cataract Research   (23) 29-32   2011   [Refereed]
High Substrate Selectivity of Mammalian D-Aspartyl Endopeptidase
T. Kinouchi, N. Fujii
KURRI Progress Report 2010   104-104   2011   [Refereed]
N. Fujii; N. Fujii; M. Kida; T. Kinouchi
Amino Acids   39(5) 1393-1399   Nov 2010   [Refereed]
S. Mizukami-Murata; H. Iwahashi; S. Kimura; K. Nojima; Y. Sakurai; T. Saitou; N. Fujii; Y. Murata; S. Suga; K. Kitagawa; K. Tanaka; S. Endo; M. Hoshi
Applied Biochemistry and Biotechnology   162(3) 855-870   Oct 2010   [Refereed]
T. Saito; T. Tezuka; R. Konno; N. Fujii
Japanese Journal of Ophthalmology   54(5) 486-493   Sep 2010   [Refereed]
Y. Yamazaki; N. Fujii; Y. Sadakane; N. Fujii
Analytical Chemistry   82(15) 6384-6394   Aug 2010   [Refereed]
M. Sugiyama; N. Fujii; Y. Morimoto; K. Itoh; K. Mori; T. Fukunaga; N. Fujii
Chemistry and Biodiversity   7(6) 1380-1388   2010   [Refereed]
T. Kinouchi; N. Fujii
Chemistry and Biodiversity   7(6) 1403-1407   2010   [Refereed]
K. Kuge; K. Kitamura; K. Nakaoji; K. Hamada; N. Fujii; T. Saito; N. Fujii
Chemistry and Biodiversity   7(6) 1408-1412   2010   [Refereed]
KAJI Yuichi;OSHIKA Tetsuro;TAKAZAWA Yutaka;FUKAYAMA Masashi;FUJII Noriko
Anti Aging Med (Web)   7(10) 107-111   2010   [Refereed]
E.A. Blakely; N.J. Kleiman; K. Neriishi; G. Chodick; L.T. Chylack; F.A. Cucinotta; A. Minamoto; E. Nakashima; T. Kumagami; T. Kitaoka; T. Kanamoto; Y. Kiuchi; P. Chang; N. Fujii; R.E. Shore
Radiation Research   173(5) 709-717   2010   [Refereed]
H. Br?ckner; N. Fujii
Chemistry and Biodiversity   7(6) 1333-1336   2010   [Refereed]
Y. Kaji; T. Oshika; Y. Takazawa; M. Fukayama; N. Fujii
Chemistry and Biodiversity   7(6) 1364-1370   2010   [Refereed]
N. Fujii; Y. Kaji; N. Fujii; T. Nakamura; R. Motoie; Y. Mori; T. Kinouchi
Chemistry and Biodiversity   7(6) 1389-1397   2010   [Refereed]
T. Kinouchi; A. Matsuda; S. Kawakami; T. Shimizu; T. Shirasawa; N. Fujii
Chemistry and Biodiversity   7(6) 1398-1402   2010   [Refereed]
Relationship between D-amino Acids and Aging
N. Fujii
Gendai Kagaku   466 42-47   2010
3-Dimensional structure observation of mammalian D-aspartyl endopeptidase by high-resolution atomic force microscopy
T. Kinouchi, N. Fujii
KURRI Progress Report 2009   136-136   2010   [Refereed]
D-aspartyl residues occur in proteins with age
N. Fujii
Bioindustry   27 6-12   2010   [Refereed]
D-amino acids and Aging.
N. Fujii
Gendaikagaku   466 42-47   2010   [Refereed]
Y. Kaji; T. Oshika; F. Okamoto; N. Fujii
British Journal of Ophthalmology   93(7) 974-976   Jul 2009   [Refereed]
G. Kashino; S. Fukutani; M. Suzuki; Y. Liu; K. Nagata; S.-I. Masunaga; A. Maruhashi; H. Tanaka; Y. Sakurai; Y. Kinashi; N. Fujii; K. Ono
Journal of Radiation Research   50(4) 377-382   Jul 2009   [Refereed]
Y. Kaji; T. Oshika; Y. Takazawa; M. Fukayama; N. Fujii
British Journal of Ophthalmology   93(7) 977-979   Jul 2009   [Refereed]
A. Shimada; H. Ozaki; T. Saito; F. Noriko
International Journal of Molecular Sciences   10(6) 2578-2590   Jun 2009   [Refereed]
R. Motoie; N. Fujii; S. Tsunoda; K. Nagata; S.-O. Tadashi; T. Kinouchi; N. Fujii; T. Saito; K. Ono
International Journal of Molecular Sciences   10(5) 1999-2009   May 2009   [Refereed]
K. Sakai-Kato; T. Kinouchi; N. Fujii; K. Imai; N. Utsunomiya-Tate
Amino Acids   36(1) 125-129   Jan 2009   [Refereed]
The Formation of D-amino Acids in Protein by UV Irradiation During Aging
N. Fujii
Laboratory animal technology and science   21 31-35   2009
Screening of D-aspartate?containing proteins using the specific proteolytic enzyme、 D-aspartyl endopeptidase
T. Kinouchi, N. Fujii
KURRI Progress Report 2008   140-0   2009   [Refereed]
Large Scale Preparation of Bio-Macromolecules with a Jar-Fermentor System to Deuterium Treatments
T. Chatake, T. Saito, N. Fujii and Y. Morimoto
KURRI Progress Report 2009   0-0   2009
Inversion of amino acids in protein by UV-irradiation and natural aging.
N. Fujii
Laboratory animal technology and science   21 31-35   2009   [Refereed]
N. Fujii; T. Hisano; N. Fujii
Biochimica et Biophysica Acta - Proteins and Proteomics   1784(11) 1507-1513   Nov 2008   [Refereed]
Masaaki Sugiyama, Noriko Fujii, Yukio Morimoto
Neutron network news   18(4) 191-196   Oct 2008   [Refereed]
T. Nakamura; M. Sakai; Y. Sadakane; T. Haga; Y. Goto; T. Kinouchi; T. Saito; N. Fujii
Biochimica et Biophysica Acta - Proteins and Proteomics   1784(9) 1192-1199   Sep 2008   [Refereed]
The Presence of D-amino Acids in the Proteins Obtained from Elderly Donors
N. Fujii and Y. Kaji
Seikagaku   80 287-293   2008
M. Sugiyama; N. Fujii; Y. Morimoto; S. Kurabayashi; M.E. Vigild; T. Nakagawa; T. Sato; K. Itoh; K. Mori; T. Fukunaga
Biomacromolecules   9(2) 431-434   2008   [Refereed]
Recemization of aspartyl residues of proteins in age-related disease
N. Fujii; Y. Kaji
Seikagaku   80(4) 287-293   2008   [Refereed]
The Role of Advanced Glycated End Products (AGE) and D-amino Acids in Eyes during Aging Ophthalmological Practice
Y. Kaji and N. Fujii
Anti Aging Ophthalmology 22 Bunkodo Tsubta K. Edited   164-169   2008
Eye Diseases Induced by Post-translational Modifications of Proteins
N. Fujii and Y. Kaji
Japanese Ophthalmology   79 289-293   2008
New Research of D-amino Acids in Living Body
N. Fujii and H. Homma
Jikken Igaku   26 1278-1284   2008
Racemization of aspartyl residues of proteins in age-related diseases, Frontier Science in Amino Acid and Protein Research
Noriko Fujii and Yuichi Kaji,
SEIKAGAKU   80 287-293   2008   [Refereed]
Ocular diseases related abnormal accumulation of modified proteins
Y. Kaji and N. Fujii
Pharma Medica   28 61-64   2008   [Refereed]
眼の加齢性変化におけるAGEとD-アミノ酸の役割 坪田一男編
Y. Kaji and N. Fujii
Practical ophthalmology ; 22   164-169   2008
ISBN-10: 4830655798
ISBN-13: 978-4830655791
Eye diseases induced by the posttranslational modifications of proteins
藤井紀子
Journal of Japan Ophthalmologists Association   79 289-293   2008   [Refereed]
New development of D- amino acids in living system.
藤井紀子
Experimental Medicine   26 1278-1284   2008   [Refereed]
Y. Kaji; T. Oshika; Y. Takazawa; M. Fukayama; T. Takata; N. Fujii
Investigative Ophthalmology and Visual Science   48(9) 3923-3927   Sep 2007   [Refereed]
M. Sugiyama; N. Fujii; Y. Morimoto; T. Otomo; S. Takata; M. Misawa; M. Annaka; K. Itoh; K. Mori; T. Sato; S. Kurabayashi; T. Fukunaga
Journal of Applied Crystallography   40 S200-S204   Apr 2007   [Refereed]
N. Fujii; T. Nakamura; Y. Sadakane; T. Saito; N. Fujii
Biochimica et Biophysica Acta - Proteins and Proteomics   1774(3) 345-350   Mar 2007   [Refereed]
T. Kinouchi; H. Nishio; Y. Nishiuchi; M. Tsunemi; K. Takada; T. Hamamoto; Y. Kagawa; N. Fujii
Amino Acids   32(1) 79-85   Jan 2007   [Refereed]
N. Fujii; Y. Shimmyo; M. Sakai; Y. Sadakane; T. Nakamura; Y. Morimoto; T. Kinouchi; Y. Goto; K. Lampi
Amino Acids   32(1) 87-94   Jan 2007   [Refereed]
K. Kuge; A. Brack; N. Fujii
Chemistry - A European Journal   13(19) 5617-5621   2007   [Refereed]
D-amino acids: A new frontier in amino acid and protein research - practical methods and protocols
R. Konno; H. Br?ckner; A. D'Aniello; G. Fisher; N. Fujii; H. Homma
D-Amino Acids: A New Frontier in Amino Acid and Protein Research - Practical Methods and Protocols   1-629   2007   [Refereed]
Detection of the specific D-aspartic acid residues in protein
N. Fujii; T. Takata
D-Amino Acids: A New Frontier in Amino Acid and Protein Research - Practical Methods and Protocols   355-367   2007   [Refereed]
紫外線の蛋白質分子への影響
N. Fujii
Photomedicine and photobiology   29th 20   2007   [Refereed]

Books etc

 
The Importance of the Idea of “Parachirality” in Life Science.
Noriko Fujii, Norihiko Fujii, Takumi Takata and Hiroaki Sakaue. (Part:Joint Work)
Elsevier Inc.   2017   ISBN:978-0-12-812824-4
D-Amino acid residues in proteins related to aging and age-related diseases and a new analysis of the isomers in proteins in "D-Amino acids:Physiology, Metabolism and Application"
FUJII Noriko (Part:Joint Work)
Springer   2016   ISBN:978-4-431-56075-3
皮膚蛋白質中のアスパラギン酸残基異性体と紫外線による皮膚老化の関連性
FUJII Noriko (Part:Joint Work, chapter 8)
シーエムシー出版   Apr 2015   
CSJ カレントレビュー17 「極限環境の生体分子―過酷な環境下での機能を科学する」 2014 日本化学会 放射線、紫外線照射、老化によるタンパク質への影響とその分析
FUJII Noriko (Part:Joint Work, 放射線、紫外線照射、老化によるタンパク質への影響とその分析 藤井紀子 )
日本化学会   2014   
Age Related Macular Degeneration - The Recent Advances in Basic Research and Clinical Care.
Yuichi Kaji, Tetsuro Oshika and Noriko Fujii.
InTech   2012   
D-amino-acid-containing proteins in living body--The Soai Reaction and Related Topic
Noriko Fujii, Kenzo Aki and Norhiko Fujii. edited by Gyula P?ly, Claudia Zucchi, Luciano Caglioti.
Accademia Nazionale di Scienze Lettere e Arti Modena、 Italy.   2012   
Experimental studies of chemical evolution using nuclear reactions and their associated radiations and nuclear reactions.
藤井 紀子
"The role of Radiation in the Origin and Evolution of Life". edited by Akaboshi, M. et al. Kyoto Univ. Academic Press, Kyoto,,/,163-173   2000   
Tryptophanase-catalyzed D-tryptophan degradation reaction and its siginificance for chiral homogeneity.
藤井 紀子
"The role of Radiation in the Origin and Evolution of Life. "edited by Akaboshi, M. et al. Kyoto Univ. Academic Press, Kyoto,,/,243-257   2000   
Progress in Biochilarity
Shimada A., Fujii, N., and Saito T.
Elsevier Science   2000   
The role of Radiation in the Origin and Evolution of Life. pp163-173
Akaboshi, M., Kawai, K., Tanaka, Y. Kawamoto, K. and Fujii, N.
Kyoto Univ. Academic Press   2000   
The role of Radiation in the Origin and Evolution of Life. pp243-257
Shimada, A., Shishido, H., Kogure, H., Nakamura, I., Fujii, N. and Akaboshi, M.
Kyoto Univ. Academic Press   2000   
Radiodecomposition of D, L-aspartic acid by tritium-β-rays.
藤井 紀子
"Advanves in Biochilarity", edited by Palyi et. al.,/,387-392   1999   
Spontaneous D-aspartic acid formation at specific sites of lens protein during aging
藤井 紀子
"Advanves in Biochilarity", edited by Palyi et. al.,/,305-313   1999   
Advanves in Biochilarity pp305-313
Fujii, N., Momose Y., and Akaboshi, M.
Elsevier Science   1999   

Conference Activities & Talks

 
水晶体培養細胞中のD-β-Asp含有タンパクの性質
高田 匠 藤井紀子 Dawei Yang 下岡正志 田中愛子
第29回 水晶体研究会   Jan 2003   
50代のヒト水晶体HMW画分とLMW画分から得たalphaA-クリスタリンの比較
藤井紀子、Larry Takemoto、粟倉顧譲、猪股光司
第29回 水晶体研究会   Jan 2003   
哺乳類のD-アスパラギン酸含有蛋白質分解酵素とその阻害剤について
木野内忠稔、西尾秀喜、西内祐二、渡邊正知、池田雅志、松井寿夫、香川靖雄、浜本敏郎
第75回日本生化学会大会   Oct 2002   
Lens培養細胞中のD-β-Asp含有タンパクの性質
高田 匠 藤井紀子 Dawei Yang 下岡正志 田中愛子
第75回日本生化学会大会   Oct 2002   
老化及び紫外線照射によって増加する皮膚のD-beta-Asp含有タンパク質の性質
藤井紀子、多島新吾、藤本典宏、下岡正志、高田 匠
第75回日本生化学会大会   Oct 2002   
Characterization of alpha A- crystallin from High Molecular weight aggregates present in the normal human lens [Invited]
Fujii N., Takemoto, L. J., Awakura, M. and Saito, T. poster
XVI International Congress of Eye Research   Oct 2002   
中性子照射による水晶体中α-クリスタリンの構造への影響
藤井紀子、齋藤 剛、櫻井良憲、藤井智彦、古林徹
第45回 日本放射線影響学会   Sep 2002   
ヒト白内障水晶体におけるαA-クリスタリンのAsp-58残基の異性化率の増加
藤井紀子、松本佐和子
第28回 水晶体研究会   Jan 2002   
老化による水晶体培養細胞中のD-beta-アスパラギン酸の発現について
高田匠 Dawei Yang 下岡正志 田中愛子 藤井紀子
第28回 水晶体研究会   Jan 2002   
In cataractous human lenses, isomerization at asp -58 and asp-151 residues of alpha A-crystallin is proceeding. [Invited]
Fujii N. , Takemoto L.J. and Matsumoto S.
US-Japan Cooperation Cataract Research Group Meeting   Nov 2001   
ガンマ線照射による水晶体中のalpha-クリスタリンの構造への影響とシャペロン機能の低下
藤井紀子、廣木孝典、多中良栄、井上将彦
第44回放射線影響学会   Oct 2001   
哺乳類のD-アスパラギン酸含有蛋白質分解酵素とその阻害剤について
木野内忠稔、香川靖雄、浜本敏郎
第74回日本生化学会大会   Oct 2001   
老化と水晶体培養細胞中のD-beta-アスパラギン酸の発現について
高田匠 Dawei Yang 下岡正志 田中愛子 藤井紀子
第74日本生化学会大会   Oct 2001   
老化及び白内障によるヒトαA-クリスタリン中のAsp-58残基の反転と異性化
藤井紀子, 松本佐和子, Larry Takemoto
第74日本生化学会大会   Oct 2001   
加齢及び紫外線照射によって生じるタンパク質中のアミノ酸の反転と異性化の生成およびその機構 [Invited]
藤井紀子
第36回 天然物化学懇話会   Aug 2001   
紫外線照射によって増加する皮膚のD-beta-Asp含有タンパク質の性質
藤井紀子、多島新吾、下岡正志、赤星光彦
第26回生命の起原および進化学会学術講演会   Mar 2001   
D-アスパラギン酸含有蛋白質に特異的な分解酵素と、その阻害剤について
木野内忠稔、香川靖雄
シンポジウム「D-アミノ酸バイオシステムの医化学」   Feb 2001   
キラルな反応場によって生じるヒトαA-クリスタリン中のAsp-151残基の反転、異性化反応
藤井紀子、松本佐和子、廣木孝典、粟倉顧譲
第27回水晶体研究会   Jan 2001   
D-アスパラギン酸含有蛋白質に特異的な分解酵素の探索とその性質について
木野内忠稔、香川靖雄、浜本敏郎
第23回日本分子生物学会年会   Dec 2000   
老化及び紫外線照射によるD-beta-アスパラギン酸生成とその局在
藤井紀子、下岡正志、多島新吾
第73回日本生化学会   Oct 2000   
哺乳類におけるD-アスパラギン酸含有蛋白質に特異的な分解酵素について
木野内忠稔、香川靖雄、浜本敏郎
第73回日本生化学会大会   Oct 2000   
γ線および紫外線照射によるαクリスタリンのシャペロン機能への影響
廣木孝典1 松本佐和子1 多中良栄2 井上将彦2 藤井紀子
第43回放射線影響学会   Sep 2000   
D-beta-Asp特異抗体を用いた水晶体・皮膚中でのD-beta-Asp含有タンパク質の分布
藤井紀子、下岡正志、多島新吾、赤星光彦
第25回生命の起原および進化学会   Mar 2000   
老化によるヒトαA-クリスタリンのAsp-58残基の反転と異性体
松本佐和子、広木孝典、赤星光彦,,藤井紀子
第26回水晶体研究会   Jan 2000   
脳内D-アスパルチル・エンドペプチダーゼ
木野内忠稔、香川靖雄
シンポジウム「D-アミノ酸研究の最前線」   Jan 2000   
The mechanisms of formation of D-aspartic acid at specific sites of aged lens protein. [Invited]
Fujii, N., Momose, Y. and Akaboshi. M
Interdisciplinary Symposium on Biological Homochirality.   Sep 1998   
皮膚蛋白質中のアスパラギン酸残基異性体と、紫外線による皮膚老化の関連性
鈴木 結、坂上 弘明、藤井 紀子
第36回日本光医学・光生物学会   

Research Grants & Projects

 
D-amino acid and aging
Project Year: 1994   
The simultaveous stereoinversion and isomerization of Asp residue in crystallin
Project Year: 1994   
UV Radiation and D-amino Acid in Skin
Project Year: 2000