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生物学

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FUJII Noriko

 
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NameFUJII Noriko
e-mailnfujiirri.kyoto-u.ac.jp
AffiliationKyoto University
SectionResearch Reactor Institute, Research Reactor Institute Division of Radiation Life Science
Job titleProfessor,Professor
DegreeDoctor of Medicine
Research funding number90199290

Research Interests

 
crystallin , racemization , Abnormal aggregation of protein , cataract , aging , D-amino acid , Biochemistry

Research Areas

 
  • Biological science / Functional biochemistry / 

Education

 
 
 - 
1980
Graduate School, Division of Medicine, Tokyo Medical and Dental University
 
 
 - 
1974
Faculty of Agriculture, Meiji University
 

Published Papers

 
L. Caglioti; O. Holczknecht; N. Fujii; C. Zucchi; G. Palyi
Origins of Life and Evolution of the Biosphere   36 459-466   Dec 2006   [Refereed]
T. Takata; T. Shimo-Oka; M. Kojima; K. Miki; N. Fujii
Biochemical and Biophysical Research Communications   344(1) 263-271   May 2006   [Refereed]
T. Nakamura; Y. Sadakane; N. Fujii
Biochimica et Biophysica Acta - Proteins and Proteomics   1764(4) 800-806   Apr 2006   [Refereed]
Atomic force microscopy of mammalian repair enzyme for racemized proteins, D-aspartyl endopeptidase
T. Kinouchi; N. Fujii
KURRI Progress Report   103   2006   [Refereed]
Project research on the effects of structure and function of proteins by irradiation, and study of repair mechanism
N. Fujii
KURRI Progress Report   101   2006   [Refereed]
Differential susceptibility of alpha A- and alpha B-crystallin to gamma-irradiation
T. Saito; N. Fujii; N. Fujii
KURRI Progress Report   102   2006   [Refereed]
The Evaluation of Sun-damaged Skin by D-amino Acid
N. Fujii
Japanese Committee for Sunlight Protection Science Report   16 37-41   2006
Is the Opitcal Isomer of Amino Acid an Useful Marker of Aging?
N. Fujii
Newton   5 82-87   2006
A Study of Aging Using D-amino Acid
N. Fujii
Jikkyo Rika Shiryo   60 11-13   2006   [Refereed]
T. Takata; T. Shimo-Oka; K. Miki; N. Fujii
Biochemical and Biophysical Research Communications   334(4) 1022-1031   Sep 2005   [Refereed]
老化タンパク質中のD-アスパラギン酸の生成機構とその修復
N. Fujii
Pharmacia   41(9) 875-879   Sep 2005   [Refereed]
N. Fujii
Biological and Pharmaceutical Bulletin   28(9) 1585-1589   Sep 2005   [Refereed]
Physical Meaning of the Presence of D-Amino Acids in Living Body
N. Fujii
Jpn. J. Cancer Clin.   51 373-379   2005
Mechanism and Repair of D-aspartate Formation in Proteins from Elderly Donors
N. Fujii and T. Kinouchi
Pharmacia   41 875-879   2005
Occurrence and function of D-amino acids in living higher organisms
N. Fujii
Japanese Journal of Cancer Research   51 373-379   2005
D-Amino acid biosystem in mammal.
T. Kinouchi; N. Fujii; H. Homma
Protein, Nucleic acid Enzyme   50 453-460   2005
Detect of the first intermediate in tryptophanase-catalyzed D-tryptophan degradation reaction processes.
A. Shimada, N. Fujii, and T. Saito.
KURRI Prog. Rep.   90-90   2005
Isolation and characterization of repair enzyme for racemized proteins.
T. Kinouchi and N. Fujii.
KURRI Prog. Rep.   88-88   2005
Structural Changes of Alpha A-Crystallin and Alpha B-Crystallin by Gamma Irradiation.
T. Saito, N. Fujii and N. Fujii
KURRI Prog. Rep.   87-87   2005
The increase of heterogeneity and size of alpha-crystallin aggregate in human lens during aging.
N. Fujii, M. Sugiyama and Y. Morimoto.
KURRI Prog. Rep.   91-91   2005
Protein damage is evaluated by D-amino acids
N. Fujii
Cosmetology : annual report of cosmetology   13 29-32   2005   [Refereed]
K. Kuge; N. Fujii; Y. Miura; S. Tajima; T. Saito
Amino Acids   27(2) 193-197   Oct 2004   [Refereed]
N. Fujii; N. Takeuchi; N. Fujii; T. Tezuka; K. Kuge; T. Takata; A. Kamei; T. Saito
Amino Acids   26(2) 147-152   Mar 2004   [Refereed]
Look at the aging through D-amino acids.
N. Fujii
Chemistry and Education   52(1) 10-13   Jan 2004   [Refereed]
Y. Miura; N. Fujimoto; T. Komatsu; S. Tajima; A. Kawada; T. Saito; N. Fujii
Journal of Cutaneous Pathology   31(1) 51-56   Jan 2004   [Refereed]
N. Fujii; T. Saito
Chemical Record   4(5) 267-278   2004   [Refereed]
The damaging effect of UV-C irradiation on lens α-crystallin
N. Fujii; H. Uchida; T. Saito
Molecular Vision   10 814-820   2004   [Refereed]
The oxidation of neutron irradiated alpha-crystallin more increases than that of gamma irradiation
N. Fujii; N. Fujii; Y. Sakurai; T. Saito
KURRI Progress Report   108   2004   [Refereed]
Influence on the growth of rats of some rare earth elements blended in conventional diet
M. Tsukada; H. Nishiyama; H. Hata; K. Yamazaki; N. Fujii; Y. Nakano
KURRI Progress Report   99   2004   [Refereed]
Role of ammonium phosphates on tryptophanase activity on D-tryptophan
A. Shimada; N. Fujii; T. Saito
KURRI Progress Report   107   2004   [Refereed]
The response of Saccharomyces Cerevisiae in the irradiation using KUR
H. Iwahashi; S. Murata-Mizukami; S. Kimura; A. Maruhashi; N. Fujii; Y. Sakurai; T. Saito; K. Tanaka; S. Endo; M. Hoshi
KURRI Progress Report   123   2004   [Refereed]
Shimada A., Fujii, N., and Saito T., edited by Palyi et.al.
Elsevier Science、 Amsterdam   321-327   2004
D-amino acids in proteins and aging
N. Fujii
ESI NEWS   22 7-10   2004
Characterization of αA-crystallin from high molecular weight aggregates in the normal human lens
N. Fujii; M. Awakura; L. Takemoto; M. Inomata; T. Takata; N. Fujii; T. Saito
Molecular Vision   9(44) 315-322   Jul 2003   [Refereed]
Y. Sadakane; T. Yamazaki; K. Nakagomi; T. Akizawa; N. Fujii; T. Tanimura; M. Kaneda; Y. Hatanaka
Journal of Pharmaceutical and Biomedical Analysis   30(6) 1825-1833   Jan 2003   [Refereed]
M. Fukushima; H. Tamate; N. Fujii; Y. Nakano
Journal of Radioanalytical and Nuclear Chemistry   257(1) 105-108   2003   [Refereed]
Immunological detection of D-β-aspartate-containing protein in lens-derived cells lines
D. Yang; N. Fujii; T. Takata; T. Shimo-Oka; S. Tajima; Y. Tanaka; T. Saito
Molecular Vision   9 200-204   2003   [Refereed]
The effect of UV C irradiation on alpha-crystallin from bovine lens
N. Fujii; H. Uchida; Y. Sakurai; T. Saito
KURRI Progress Report   114   2003   [Refereed]
Induction and protective effect of metallothionein I and II in lens epithelial culture cells
T. Saito; T. Tezuka; N. Fujii
KURRI Progress Report   111   2003   [Refereed]
Quantitative analysis of inorganic elements in Japanese standard soils and rice by means of INAA
M. Tsukada; H. Hada; H. Nishiyama; K. Yamazaki; N. Fujii; Y. Nakano
KURRI Progress Report   106   2003   [Refereed]
Study on the dose estimation for the radiation effect estimation on proteins (II)
Y. Sakurai; N. Fujii; N. Fujii; T. Saito
KURRI Progress Report   112   2003   [Refereed]
Project research on the effects of neutron, gamma-ray and UV irradiation on proteins
N. Fujii
KURRI Progress Report   110   2003   [Refereed]
K. Nakagomi; K. Takatsu; S. Takagi; H. Ebisu; Y. Sadakane; N. Fujii; T. Akizawa; T. Tanimura; Y. Hatanaka
Peptides   23(9) 1567-1571   Sep 2002   [Refereed]
N. Fujii; S. Tajima; N. Tanaka; N. Fujimoto; T. Takata; T. Shimo-Oka
Biochemical and Biophysical Research Communications   294(5) 1047-1051   Jun 2002   [Refereed]
K. Nakagomi; A. Fujimura; H. Maeda; Y. Sadakane; N. Fujii; T. Akizawa; T. Tanimura; Y. Hatanaka
Biological and Pharmaceutical Bulletin   25(5) 564-568   May 2002   [Refereed]
N. Fujii
Origins of Life and Evolution of the Biosphere   32(2) 103-127   Apr 2002   [Refereed]
M. Kaneda; K. Nakagomi; Y. Sadakane; T. Yamazaki; T. Tanimura; T. Akizawa; N. Fujii; Y. Hatanaka
Journal of Liquid Chromatography and Related Technologies   25(16) 2445-2454   2002   [Refereed]
J. Takada; K. Nishimura; Y. Tanaka; N. Fujii; M. Akaboshi
Journal of Radioanalytical and Nuclear Chemistry   251(1) 149-152   2002   [Refereed]
N. Fujii; S. Matsumoto; K. Hiroki; L. Takemoto
Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology   1549(2) 179-187   Oct 2001   [Refereed]
Cataract and post-translational modifications of amino acids in protein
N. Fujii
The Journal of the Japanese Society for Cataract Research   13 70-73   May 2001   [Refereed]
L. Takemoto; N. Fujii; D. Boyle
Experimental Eye Research   72(5) 559-563   May 2001   [Refereed]
N. Fujii; K. Hiroki; S. Matsumoto; K. Masuda; M. Inoue; Y. Tanaka; M. Awakura; M. Akaboshi
Photochemistry and Photobiology   74(3) 477-482   2001   [Refereed]
A View on to the L-amino acid world through the "D-mino acid-scope"
N. Fujii
Advanves in Biophysics,      2001   [Refereed]
Three D Structure of the Vitreous Body.
N. Fujii
Viva Origino   29 45-54   2001   [Refereed]
Correlation between Loss of Chaperone-Like Activity、 and Oxidation、 Isomerization and Racemization of Gamma-Irradiated Alpha-Crystallin\n\nKUR Progress Report
N. Fujii, K. Hiroki, M.Inoue and T. Tanaka
KUR Progress Report   130-0   2001
N. Fujii; L.J. Takemoto; S. Matsumoto; K. Hiroki; D. Boyle; M. Akaboshi
Biochemical and Biophysical Research Communications   278(2) 408-413   Nov 2000   [Refereed]
K. Nakagomi; H. Ebisu; Y. Sadakane; N. Fujii; T. Akizawa; T. Tanimura
Biological and Pharmaceutical Bulletin   23(7) 879-883   Jul 2000   [Refereed]
A. Mizuno; N. Fujii; M. Akaboshi; Y. Momose; T. Shimo-Oka
Japanese Journal of Ophthalmology   44(4) 354-359   Jul 2000   [Refereed]
化学進化もまた段階的に進行する
Mitsuhiko Akaboshi, Yoshiko Tanaka, Yukihiro Nakano and Noriko Fujii
Viva Origino   28(2) 89-95   Jun 2000   [Refereed]
Localization of biologically uncommon D-?-aspartate-containing αA-crystallin in human eye lens
N. Fujii; T. Shimo-Oka; M. Ogiso; Y. Momose; T. Kodama; M. Kodama; M. Akaboshi
Molecular Vision   6(1) 1-5   2000   [Refereed]
M. Akaboshi; Y. Tanaka; Y. Nakano; K. Kawai; N. Fujii
Origins of Life and Evolution of the Biosphere   30(1) 25-32   2000   [Refereed]
Modification of αA-crystallin obtaned from aged and X-ray irradiated mouse lenses.
N. Fujii
"The Role of Radiation and Origin of Life" edited by Akaboshi. M   227-241   2000   [Refereed]
The effect of L-ascorbic acid on the differentiation of bovine lens epithelial cells in culture.
N. Fujii
Viva Origino   28 77-86   2000   [Refereed]
Increasing Activity Change of Tryptophanase Irradiated with a Low Dose of gamma-rays.
Shimada, M., Fujii, N. and Nakamura, I.
Viva Origino   28 65-76   2000   [Refereed]
Modification of alpha A-crystallin obtained from aged and X-ray irradiated mouse lenses.“The Role of Radiation and Origin of Life”
Fujii, N., Momose Y., Kodama, T., and Akaboshi, M. edited by Akaboshi, M. et al.
Kyoto Univ. Academic Press、 Kyoto   227-241   2000
希土類元素のリン酸エステル切断作用
Mitsuhiko Akaboshi, Yoshiko Tanaka, Yukihiro Nakano Kenichi Kawai and Noriko Fujii
Viva Origino   27(4) 191-195   Dec 1999   [Refereed]
N. Fujii; L.J. Takemoto; Y. Momose; S. Matsumoto; K. Hiroki; M. Akaboshi
Biochemical and Biophysical Research Communications   265(3) 746-751   Nov 1999   [Refereed]
N. Fujii; K. Harada; Y. Momose; N. Ishii; M. Akaboshi
Biochemical and Biophysical Research Communications   263(2) 322-326   Sep 1999   [Refereed]
The effect of X-ray irradiation on .ALPHA.A-crystallin.
MOMOSE Y;FUJII N;KODAMA T;YAMAGAKI T;NAKANISHI H;KODAMA M
Viva Origino   27(2) 119-131   Jun 1999   [Refereed]
N. Fujii; Y. Momose; N. Ishii; M. Takita; M. Akaboshi; M. Kodama
Mechanisms of Ageing and Development   107(3) 347-358   Mar 1999   [Refereed]
ヒト水晶体タンパク質ラセミ化ペプチドのラマン分光学的研究
Aritake Mizuno, Noriko Fujii
実用分光法シリーズNo4 分光学の医学応用 アイピーシー出版部 編者:曽沢勝夫ら   4 188-206   1999   [Refereed]
The role of radiation in the origin and evolution of life.
Mitsuhiko Akaboshi and Noriko Fujii,
Radiation Chemistry 67, 3-8 (1999)   67 3-8   1999   [Refereed]
M. Akaboshi; K. Kawai; Y. Tanaka; J. Takada; N. Fujii
Biological Trace Element Research   Feb-71 585-593   1999   [Refereed]
Y. Tanaka; K. Kawamoto; K. Kawai; J. Takada; N. Fujii; M. Akaboshi
Biological Trace Element Research   71-72 359-363   1999   [Refereed]
Radiodecomposition of D、 L-aspartic acid by tritium-beta-rays. “Advanves in Biochilarity”、 edited by Palyi et.al.
Akaboshi, M., Kawai, K., Tanaka, Y., and Fujii, N.
Elsevier Science、 Amsterdam   387-392   1999
Spontaneous D-aspartic acid formation at specific sites of lens protein during aging. “Advanves in Biochilarity”、
Fujii, N., Momose Y., and Akaboshi, M. edited by Palyi et.al.
Elsevier Science、 Amsterdam   305-313   1999
K. Nakagomi; A. Fujimura; H. Ebisu; T. Sakai; Y. Sadakane; N. Fujii; T. Tanimura
FEBS Letters   438(3) 255-257   1998   [Refereed]
白内障を化学する
N. Fujii
KAGAKU TO SEIBUTU   35 346-350   1997   [Refereed]
N. Fujii; Y. Momose; Y. Ishibashi; T. Uemura; M. Takita; M. Takehana
Experimental Eye Research   65(1) 99-104   1997   [Refereed]
Y.-K. Liu; T. Uemura; A. Nemoto; T. Yabe; N. Fujii; T. Ushida; T. Tateishi
FEBS Letters   420(1) 112-116   1997   [Refereed]
N. Fujii; Y. Momose; M. Yamasaki; T. Yamagaki; H. Nakanishi; T. Uemura; M. Takita; N. Ishii
Biochemical and Biophysical Research Communications   239(3) 918-923   1997   [Refereed]
タンパク質中のアミノ酸残基の反転、ラセミ化、異性化とその機構―老化との関連
N. Fujii
Seikagaku   68 1641-1645   1996   [Refereed]
Kinetic study of racemization of aspartyl residues in model peptides of αA-crystallin
N. Fujii; Y. Momose; K. Harada
International Journal of Peptide and Protein Research   48(2) 118-122   1996   [Refereed]
Simultaneous stereoinversion, racemization and isomerization at specific amino acid residues in the proteins during aging
N. Fujii
Seikagaku   68(10) 1641-1645   1996   [Refereed]
D−アミノ酸を通して生物を見るー老化、発生、生命の起源
N. Fujii
化学   50 286-291   1995   [Refereed]
Simultaneous stereoinversion and isomerization at specific aspartic acid residues in αA-crystallin from human lens
N. Fujii; K. Satoh; K. Harada; Y. Ishibashi
Journal of Biochemistry   116(3) 663-669   1994   [Refereed]
A. Hashimoto; T. Nishikawa; T. Hayashi; N. Fujii; K. Harada; T. Oka; K. Takahashi
FEBS Letters   296(1) 33-36   1992   [Refereed]
S. Muraoka; N. Fujii; Y. Ueda; Y. Mitsui; K. Satoh; K. Harada
Biomedical Research   12(1) 61-64   1991   [Refereed]
The properties of D-amino acid containing proteins in aging tissue.
Noriko Fujii and Kaoru Harada
Jasco Report   32 9-14   1990   [Refereed]
Dーアミノ酸から見た老化と進化
Noriko Fujii, Shiro Muraoka, Kaoru Harada
Biotrends   2 26-30   1990   [Refereed]
新分析技術によって明らかになった生体内D−アミノ酸の推移
Noriko Fujii, Shiro Muraoka, Kaoru Harada
ぶんせき   10 782-785   1990   [Refereed]
N. Fujii; S. Muraoka; K. Harada
Biochimica et Biophysica Acta (BBA)/Protein Structure and Molecular   999(3) 239-242   1989   [Refereed]
S. Muraoka; N. Fujii; I. Tamanoi; K. Harada
Biochemical and Biophysical Research Communications   146(3) 1432-1438   1987   [Refereed]
武者塚古墳ー毛髪による古温度の推定
Noriko Fujii and Akira Shimoyama
茨城県教育委員会   91-94   1986   [Refereed]
N. Fujii; I. Tamanoi; H. Joshima; M. Kashima; K. Harada
Journal of radiation research   27(2) 183-190   1986   [Refereed]
アミノ酸のラセミ化を利用する分子時計
Noriko Fujii and Kaoru Harada
化学の領域   36 606-616   1982   [Refereed]
Takata T and Fujii N.
FEBS J.   -in press   [Refereed]

Books etc

 
The Importance of the Idea of “Parachirality” in Life Science.
Noriko Fujii, Norihiko Fujii, Takumi Takata and Hiroaki Sakaue. (Part:Joint Work)
Elsevier Inc.   2017   ISBN:978-0-12-812824-4
D-Amino acid residues in proteins related to aging and age-related diseases and a new analysis of the isomers in proteins in "D-Amino acids:Physiology, Metabolism and Application"
FUJII Noriko (Part:Joint Work)
Springer   2016   ISBN:978-4-431-56075-3
皮膚蛋白質中のアスパラギン酸残基異性体と紫外線による皮膚老化の関連性
FUJII Noriko (Part:Joint Work, chapter 8)
シーエムシー出版   Apr 2015   
CSJ カレントレビュー17 「極限環境の生体分子―過酷な環境下での機能を科学する」 2014 日本化学会 放射線、紫外線照射、老化によるタンパク質への影響とその分析
FUJII Noriko (Part:Joint Work, 放射線、紫外線照射、老化によるタンパク質への影響とその分析 藤井紀子 )
日本化学会   2014   
Age Related Macular Degeneration - The Recent Advances in Basic Research and Clinical Care.
Yuichi Kaji, Tetsuro Oshika and Noriko Fujii.
InTech   2012   
D-amino-acid-containing proteins in living body--The Soai Reaction and Related Topic
Noriko Fujii, Kenzo Aki and Norhiko Fujii. edited by Gyula P?ly, Claudia Zucchi, Luciano Caglioti.
Accademia Nazionale di Scienze Lettere e Arti Modena、 Italy.   2012   
Experimental studies of chemical evolution using nuclear reactions and their associated radiations and nuclear reactions.
藤井 紀子
"The role of Radiation in the Origin and Evolution of Life". edited by Akaboshi, M. et al. Kyoto Univ. Academic Press, Kyoto,,/,163-173   2000   
Tryptophanase-catalyzed D-tryptophan degradation reaction and its siginificance for chiral homogeneity.
藤井 紀子
"The role of Radiation in the Origin and Evolution of Life. "edited by Akaboshi, M. et al. Kyoto Univ. Academic Press, Kyoto,,/,243-257   2000   
Progress in Biochilarity
Shimada A., Fujii, N., and Saito T.
Elsevier Science   2000   
The role of Radiation in the Origin and Evolution of Life. pp163-173
Akaboshi, M., Kawai, K., Tanaka, Y. Kawamoto, K. and Fujii, N.
Kyoto Univ. Academic Press   2000   
The role of Radiation in the Origin and Evolution of Life. pp243-257
Shimada, A., Shishido, H., Kogure, H., Nakamura, I., Fujii, N. and Akaboshi, M.
Kyoto Univ. Academic Press   2000   
Radiodecomposition of D, L-aspartic acid by tritium-β-rays.
藤井 紀子
"Advanves in Biochilarity", edited by Palyi et. al.,/,387-392   1999   
Spontaneous D-aspartic acid formation at specific sites of lens protein during aging
藤井 紀子
"Advanves in Biochilarity", edited by Palyi et. al.,/,305-313   1999   
Advanves in Biochilarity pp305-313
Fujii, N., Momose Y., and Akaboshi, M.
Elsevier Science   1999   

Conference Activities & Talks

 
生体分子ホモキラリティーのパラダイムシフト − D-アミノ酸研究の新展開
藤井紀子、本間浩
第88回日本生化学会・第37回日本分子生物学会年会合同大会   Dec 2015   
蛋白質異常凝集とD-アミノ酸 (八谷:アミロイド再考) [Invited]
藤井 紀子
第88回日本生化学会・第37回日本分子生物学会年会合同大会   Dec 2015   
Crystallin racemization and insolubilization of lens proteins [Invited]
Noriko Fujii
International Conference on the Lens 2015   Dec 2015   
蛋白質異常凝集とD-アミノ酸 [Invited]
藤井紀子
第88回日本生化学会・第37回日本分子生物学会年会合同大会   Dec 2015   
老化における蛋白質ホモキラリテイーの破れ [Invited]
FUJII Noriko
さきがけ20周年記念講演会 さきがけ研究21「場と領域」研究領域   14 Nov 2015   
「LC-MSを用いた白内障クリスタリン中の異性体アミノ酸の迅速分析法」 [Invited]
藤井紀子
第54回日本白内障学会総会・第41回水晶体研究会 合同開催   18 Sep 2015   
LC-MSを用いた白内障クリスタリン中の異性体アミノ酸の迅速分析法 [Invited]
藤井 紀子
第54回日本白内障学会総会・第41回水晶体研究会   Sep 2015   
The importance of the idea of “Parachirality” in life science [Invited]
Noriko Fujii
3rd International Symposium on the SOAI Reaction and Related Topic   Sep 2015   
LC-MSを用いた皮膚コラーゲン中のD-アスパラギン酸残基の部位の決定
藤井 紀子、鈴木 結
第37回日本光医学・光生物学会   Jul 2015   
Isomerizations of aspartyl residues in lens crystallins from age-related cataracts. [Invited]
FUJII Noriko
Asia-ARVO 2015 Symposium   16 Feb 2015   
Rapid Analysis of D-amino acids in Proteins using LC-MS [Invited]
Noriko Fujii
Origins 2014   6 Jul 2014   
Organising committee
LC-MS/MS による蛋白質中のAsp 異性体の迅速解析 [Invited]
藤井紀子
第15 回日本蛋白質科学会年会   24 Jun 2015   
LC-MS/MS による蛋白質中のAsp 異性体の迅速解析 [Invited]
藤井 紀子
第15 回日本蛋白質科学会年会   Jun 2015   
血液中のD-アミノ酸含有ペプチドの探索
HA SEONGMIN, 高田匠、藤井紀子
第15 回日本蛋白質科学会年会   Jun 2015   
ラット水晶体タンパク質に対するγ線照射の影響
金 仁求、齊藤 毅、金本尚志,藤井 智彦、藤井 紀子
第40回生命の起原および進化学会学術講演会   Mar 2015   
結合型D-アミノ酸形成が誘起する水晶体蛋白質の不溶化
高田匠、藤井紀子
第40回生命の起原および進化学会学術講演会   Mar 2015   
Rapid Analysis of the Isomers of Individual Asp residues in Lens Crystallins from Elderly Donors Using LC-MS [Invited]
Noriko Fujii
International Conference on the Lens   19 Jan 2014   
LC-MSによる結合型D-アミノ酸分析
藤井 紀子、 高田匠、 藤井智彦
第40回生命の起原および進化学会学術講演会   Mar 2015   
放射線照射によるシアル酸(Neu5Ac)の脱炭酸反応生成物ADOAの生成促進
藤井智彦1、飯島亮介2、油井聡2、藤井紀子3、岸本成史
日本薬学会 第135年会   Mar 2015   
ペプチド・蛋白質中の異性化したアスパラギン酸残基の新しい分析方法
藤井智彦1、岸本成史1,2、藤井紀子
日本薬学会 第135年会   Mar 2015   
Isomerizatons of [Invited]
Noriko Fujii, Takumi Takata, Norihiko Fujii, Hiroshi Sasaki
Asia-ARVO 2015 Symposium   16 Feb 2015   
Protein aggregation and racemization of amino acids [Invited]
Noriko FUJII, Norihiko FUJII, Takumi TAKATA, Hiroki MAEDA, Hiroaki SAKAUE
Japan-Hungary Joint Seminar "Mechanism and regulation of aberrant protein aggregation"   18 Nov 2014   
放射線照射によるγークリスタリン中のアミノ酸残基の酸化
金 仁求、高田 匠、齊藤 毅、藤井 智彦、藤井 紀子
第87回日本生化学会   Oct 2014   
LC-MSを用いた皮膚蛋白質中のアスパラギン酸(Asp)残基の異性体分析
鈴木 結、藤井 紀子、坂上 弘明
第87回日本生化学会   Oct 2014   
A new method for the analysis of isomerization of individual Asp residues in proteins using LC-MS. [Invited]
Noriko Fujii
2nd Annual Conference and EXPO of AnalytiX-2013   20 Mar 2013   
Asp異性化がポリペプチド会合体へ及ぼす影響
高田匠、藤井紀子
第87回日本生化学会   Oct 2014   
Analysis of Aspartyl Isomers in Skin Protein by LC-MS/MS.
Yui SUZUKI, Noriko FUJII, Hiroaki SAKAUE
The 2nd International Conference of D-Amino Acid Research IDAR2014   2 Sep 2014   
The Hunt for D-aspartyl endopeptidase in various living things:Vertebrates, Aquatic animals and Plants.
Tadatoshi Kinouchi and Noriko Fujii
The 2nd International Conference of D-Amino Acid Research IDAR2014   2 Sep 2014   
Oxidation and Racemization of Rat Lens Crystallins by gamma Irradiation
Ingu Kim, Takeshi Saito and Noriko Fujii
The 2nd International Conference of D-Amino Acid Research IDAR2014   2 Sep 2014   
Inversion of Aspartyl Residue Disturbs Assembly of Crystallin in Human Cataract Lens.
Hiroaki SAKAUE, Takumi TAKATA, Norihiko FUJII, Hiroshi SASAKI and Noriko FUJII
The 2nd International Conference of D-Amino Acid Research IDAR2014   2 Sep 2014   
Asp Isomerization in Eye Lens Derived Peptide Associated with Pepitde-Pepitde and Peptide _Protein Interactions.
Takumi Takata, Hiroaki Sakaue, Noriko Fujii
The 2nd International Conference of D-Amino Acid Research IDAR2014   2 Sep 2014   
Vice president
水晶体蛋白質のアスパラギン酸残基の異性化と立体構造との関係
藤井 智彦、 岸本 成史、 佐々木 洋、 藤井 紀子
第53回 日本白内障学会総会   Sep 2014   
アスパラギン酸残基の異性化によるクリスタリン会合体の解離
藤井 紀子、 坂上弘明、 高田匠、 藤井智彦、佐々木 洋
第53回 日本白内障学会総会   Sep 2014   
A novel rapid comprehensive analysis of D-amino acids in cataract lens proteins using LC-MS [Invited]
Noriko Fujii
The 2nd International Conference of D-Amino Acid Research IDAR2014   Sep 2014   
Abnormal protein aggregation due to the presence of D-aspartyl residues in cataractous lenses. [Invited]
Noriko Fujii, Norihiko Fujii and Masaaki Sugiyama
12th Annual Meeting of International Union of Materials Research Societies (IUMRS) - International Conference in Asia (ICA)   19 Sep 2011   
Deamidations In β-crystallin Family Are Highly Correlated With Lens Insolubulization During Aging
T. Takata, N. Fujii, K. Lampi.
第14 回日本蛋白質科学会年会   Jun 2014   
老化や酸化ストレスによるD-アミノ酸含有蛋白質の蓄積 [Invited]
藤井紀子
第14回 日本抗加齢医学会総会   Jun 2014   
加齢性眼疾患における蛋白質の変化をとらえる化学的アプローチ [Invited]
藤井紀子
第118回日本眼科学会総会   Apr 2014   
LC-MSを用いた皮膚蛋白質中のアスパラギン酸(Asp)残基の異性体分析
鈴木 結、坂上 弘明、藤井 紀子
生命の起原および進化学会第 39回 学術講演会   Mar 2014   
γ線照射によるγ-クリスタリン中のアミノ酸残基の酸化
金仁求、高田匠、齊藤剛、藤井智彦、 金本尚志、藤井紀子
生命の起原および進化学会第 39回 学術講演会   Mar 2014   
放射線照射による蛋白質への影響 [Invited]
藤井紀子
シンポジウム「宇宙にひろがる人類文明の未来」   Feb 2014   
D−アスパラギン酸が惹起する蛋白質の異常凝集と加齢性疾患 [Invited]
藤井紀子
ビタミン B 研究委員会 平成25年度シンポジウム   31 Jan 2014   
脱アミド化が引き起こすβB1-βA3クリスタリン分子間相互作用変化
高田匠, Kirsten Lampi, 藤井紀子
第40回 水晶体研究会   Jan 2014   
水晶体構成タンパク質中のアスパラギン酸の異性化と立体構造の関係
藤井 智彦、佐々木 洋、藤井 紀子
第40回 水晶体研究会   Jan 2014   
βB2-クリスタリンC末端Asn残基の異性化が引き起こす同一分子間相互作用変化
西岡紀理、藤井智彦、高田匠、藤井紀子
第40回 水晶体研究会   Jan 2014   
放射線照射による水晶体クリスタリンの構造機能変化とAsp異性体の一斉解析、シンポ名:「放射線と水晶体」 [Invited]
藤井紀子
第67回日本臨床眼科学会総会シンポジウム   31 Oct 2013   
白内障患者の水晶体蛋白質に生じている化学変化をとらえる定量的アプローチ [Invited]
藤井紀子
TRF研究会   30 Oct 2013   
LC-MSを用いたタンパク質中のDアスパラギン酸残基の新しい分析方法 
藤井智彦、藤井紀子
第9回D-アミノ酸研究会学術講演会   Sep 2013   
紫外線による皮膚コラーゲン中のアミノ酸の異性化
鈴木結、坂上弘明、藤井紀子
第9回D-アミノ酸研究会学術講演会   Sep 2013   
ヒト扁桃におけるアスパラギン残基の脱アミドおよびアスパラギン酸残基の異性
前田裕貴、藤井智彦、高橋裕一、藤井紀子
第9回D-アミノ酸研究会学術講演会   Sep 2013   
αAクリスタリンの部分ペプチドを用いたAsp異性化シミュレーション 
安岐 健三 、藤井紀子
第86回日本生化学会大会   Sep 2013   
The effects of gamma irradiation on lens proteins of human alpha A- and alpha B-cyrstallins
Norihiko. Fujii1, Tamao. Hisano2, Takeshi. Saito1, & Noriko. Fujii
XVIII International Congress of Eye Research   24 Sep 2008   
Effect of primary and higher order structures on the racemization of Asp 58 and Asp 151 in alpha A-crystallin [Invited]
N. Fujii and T. Nakamura
XVIII International Congress of Eye Research   24 Sep 2008   
加齢、紫外線、電離放射線による水晶体蛋白質の変化 (16:50-17:20)講演 [Invited]
藤井紀子
文部科学省復興対策特別人材育成事業「被ばくの瞬間から生涯を見渡す放射線生物・医学の学際教育」   25 Aug 2013   
蛋白質の異常凝集 (8/24、16:30-17:30)講義 [Invited]
藤井紀子
文部科学省復興対策特別人材育成事業「被ばくの瞬間から生涯を見渡す放射線生物・医学の学際教育」   24 Aug 2013   
蛋白質の異常凝集 
藤井 紀子
文部科学省復興対策特別人材育成事業「被ばくの瞬間から生涯を見渡す放射線生物・医学の学際教育」   Aug 2013   
加齢、紫外線、電離放射線による水晶体蛋白質の変化
藤井 紀子
文部科学省復興対策特別人材育成事業「被ばくの瞬間から生涯を見渡す放射線生物・医学の学際教育」   Aug 2013   
紫外線照射によるペプチド中のトリプトファン残基の酸化とアスパラギン酸残基の異性化の関係
藤井紀子、蔡思敏、藤井智彦
第35回 日本光医学光生物学会    Jul 2013   
LC-MSによる白内障の水晶体蛋白質中のアスパラギン酸残基の異性体の分析 [Invited]
藤井紀子、藤井智彦
第52回 日本白内障学会総会   27 Jun 2013   
Structural investigation of βB2 crystallin and its complex in an aqueous solution. 2
Masaki Sugiyama, Norihiko Fujii and Noriko Fujii.
XX Biennial Meeting of the International Society for Eye Research (ISER 2012)   21 Jul 2012   
The dissociation of a-crystallin-aggregate due to a specific D-Asp residue in αB-crystallin.
XX Biennial Meeting of the International Society for Eye Research (ISER 2012)   21 Jul 2012   
Characterization of alpha-crystallin aggregates from human eye lenses and recombinant human alpha A- and alpha B -crystallins aggregates. [Invited]
Noriko Fujii, Yoshiari Shimmyo, Masaaki Sugiyama, Miyo Sakai, Yutaka Sadakane, Tooru Nakamura, Sakie Kurabayashi, Yukio Morimoto, Masahiko Annaka , Tadatoshi Kinouchi, Yuji Goto and Kirsten Lampi
XVII International Congress of Eye Research   29 Oct 2006   
Identification of β-aspartic acid residues in protein by MALD-TOFMS.
Norihiko Fujii, Yuzo Yamazaki and Noriko Fujii
XX Biennial Meeting of the International Society for Eye Research (ISER 2012)   21 Jul 2012   
Simultaneous inversion and isomerization of Asp residues at N-and C-terminal regions in _B2-crystallin from the aged human cataractous lenses.
Noriko Fujii, Tomohiro Minooka, Norihiko Fujii, Takehiro Kawaguchi and Hiroshi Sasaki.
XX Biennial Meeting of the International Society for Eye Research (ISER 2012)   21 Jul 2012   
Simultaneous isomerization at the Asp-4 residue in βB2-crystallin from the aged human eye lenses
Norihiko Fujii,Takehiro Kawaguchi, Hiroshi Sasaki and Noriko Fujii
International Conference on the Lens   15 Jan 2012   
Quality control of damaged mitochondrial proteins by D-aspartyl endopeptidase.
Kinouchi Tadatoshi and Noriko Fujii
7th Conference of Asian Society for Mitochondrial Research and Medicine (ASMRM) and 10th Conference of Japanese Society of Mitochondrial Research and Medicine   16 Dec 2010   
THE ASP ISOMERS AFFECT THE PROPERTIES OF aA-CRYSTALLIN MIMIC PEPTIDE
Noriko Fujii, Norihiko Fujii, Masashi Kida and Tadatoshi Kinouchi
XIX Biennial Meeting of the International Society for Eye Research (ISER 2010)   18 Jul 2010   
Differentiating alpha- and beta-aspartic acids by MALDI and PSD on Curved Field Reflectron
Yuzo Yamazaki1, Norihiko Fujii2 and Noriko Fujii2
18th International Mass Spectrometry Conference,   30 Aug 2009   
PROTECTION EFFECTS BY METALLOTHIONEIN IN MOUSE LENS EPITHELIAL CELL
Takeshi Saito, Tomoyuki Tezuka, Ryuichi Konno, Noriko Fujii
International Symposium on Origins of Life and Astrobiology30th SSOEL-JAPAN MEETING ISOLAB’05   27 Jun 2005   
KINETIC STUDY OF RACEMIZATION OF ASPARTYL RESIDUES IN MODEL PEPTIDES CORRESPONDING TO SECTIONS OF ELASTIN.
Katsunori Kuge, Shingo Tajima and Noriko Fujii
International Symposium on Origins of Life and Astrobiology30th SSOEL-JAPAN MEETING ISOLAB’05   27 Jun 2005   
CHARACTERIZATION OF NEW D-BETA-ASPARTATE CONTAINING PROTEINS IN A LENS-DERIVED CELL LINE
Takumi Takata, Tadashi Shimo-Oka ,Kunio Miki and Noriko Fujii
International Symposium on Origins of Life and Astrobiology30th SSOEL-JAPAN MEETING ISOLAB’05   27 Jun 2005   
Mammalian D-aspartyl endopeptidase: a scavenger for noxious racemized proteins in aging.
Tadatoshi Kinouchi, Toshiro Hamamoto, Yasuo Kagawa and Noriko Fujii
International Symposium on Origins of Life and Astrobiology30th SSOEL-JAPAN MEETING ISOLAB’05   27 Jun 2005   
Spontaneous D-amino acid Formation in Protein from Elderly Human Tissues. [Invited]
Noriko Fujii, Katsunori Kuge, Ryota Motoie, Tadashi ShimoOka and Shingo Tajima
2005 Isolab   27 Jun 2005   
Simultaneous racemization and glycation of amino acid residues in proteins in UVB irradiated skin
Yuhei Mori, Kenzo Aki, Tadatoshi Kinouchi, TakehiroKawaguti , Masashi Kida , Hiroaki Sakaue , Noriko Fujii
the First International Congress of D-Amino Acid Research   1 Jul 2009   
Substrate specificity and properties of mammalian D-aspartyl endpeptidase
Tadatoshi Kinouchi, Takeshi Saito and Noriko Fujii
the First International Congress of D-Amino Acid Research   1 Jul 2009   

Research Grants & Projects

 
D-amino acid and aging
Project Year: 1994   
The simultaveous stereoinversion and isomerization of Asp residue in crystallin
Project Year: 1994   
UV Radiation and D-amino Acid in Skin
Project Year: 2000